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Effect of cyclic mechanical loading on immunoinflammatory microenvironment in biofabricating hydroxyapatite scaffold for bone regeneration

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Bioactive Materials 2021年第10期6卷 3097-3108页

作者： Penghui Zhang Xizhe Liu Peng Guo Xianlong Li Zhongyuan He Zhen Li Martin J.Stoddart Sibylle Grad Wei Tian Dafu Chen Xuenong Zou Zhiyu Zhou Shaoyu Liu Innovation Platform of Regeneration and Repair of Spinal Cord and Nerve Injury Department of Orthopaedic SurgeryThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen518107China Guangdong Provincial Key Laboratory of Orthopedics and Traumatology Orthopaedic Research Institute/Department of Spinal SurgeryThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510080China AO Research Institute Davos Clavadelerstrasse 8Davos7270Switzerland Laboratory of bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsBeijing Research Institute of Orthopaedics and TraumatologyBeijing JiShuiTan HospitalBeijing100035China

It has been proven that the mechanical microenvironment can impact the differentiation of mesenchymal stem cells(MSCs).However,the effect of mechanical stimuli in biofabricating hydroxyapatite scaffolds on the inflammatory response of MSCs remains *** study aimed to investigate the effect of mechanical loading on the inflammatory response of MSCs seeded on *** mechanical loading was applied to biofabricate the cell-scaffold composite for 15 min/day over 7,14,or 21 *** the predetermined time points,culture supernatant was collected for inflammatory mediator detection,and gene expression was analyzed by *** results showed that the expression of inflammatory mediators(IL1B and IL8)was downregulated(pbone volume/total volume ratio in ***,these findings demonstrated that mechanical loading could dually modulate the inflammatory responses and osteogenic differentiation of ***,the ECM-based scaffolds that were biofabricated with mechanical loading before freeze-drying facilitated the M2 polarization of macrophages in vitro and bone regeneration in *** loading may be a promising biofabrication strategy for bone biomaterials.

关键词： Bioreactor Biofabrication Inflammatory microenvironment bone biomaterials Macrophage polarization

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Heparan-mimetics:Potential agents of tissue regeneration for bone and periodontal therapies

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Medicine in Novel Technology and Devices 2021年第3期11卷 1-10页

作者： Maroun Bou Karam Joe El Khoury Carole Chakar Sylvie Changotade Didier Lutomski Nada Naaman Gaston Godeau Abdellatif Elm’selmi Ronald Younes Karim Senni Craniofacial Research Laboratory Faculty of Dental MedicineSaint Joseph University of BeirutLebanon Department of Periodontology Faculty of Dental MedicineSaint Joseph University of BeirutLebanon Universite Sorbonne Paris Nord Unite de Recherche Biomateriaux Innovants et InterfacesURB2IUR 4462F-93000BobignyFrance Universite de Paris F-92049MontrougeFrance EBInnov School of Industrial Biology-EBICergyFrance Department of Oral Surgery Faculty of Dental MedicineSaint Joseph University of BeirutLebanon

Heparan sulfate glycosaminoglycans are key players of tissue repair and can be regarded as useful compounds for regenerative ***,their therapeutic uses face many technical,industrial,and regulatory hurdles due to their animal ***,some non-animal sulfated polysaccharides mimic heparan sulfate properties and offer interesting solutions to replace *** them,dextran derivatives,seaweed polysaccharides,or marine bacterial polysaccharides are the best known and have demonstrated their pro-regenerative capabilities by promoting both extracellular matrix structuring and angiogenesis and limiting degenerative processes such as inflammatory cell migration or tissue *** polysaccharides have also shown their ability to specifically promote osteoblastic differentiation and bone wound ***,recent works shows that heparan-mimetics can be used as an additive to improve the cytocompatibility of bone substitutes commonly used in periodontal *** use of these polysaccharides can be regarded as a clever approach to improve the biointegration of bone substitutes.

关键词： bone biomaterials Periodontal surgery Heparan-mimetics Marine biotechnology Dextran derivatives Bacterial exopolysaccharides Fucoidans

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