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Profile of Malignant bone tumors among Rheumatology Inpatients in Lome (Togo)

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Open Journal of Rheumatology and Autoimmune Diseases 2016年第3期6卷 51-56页

作者： Kodjo Kakpovi Prénam Houzou Eyram Fianyo Messanvi Kpoti Viwalé E. S. Koffi-Tessio Komi C. Tagbor Owonayo Oniankitan Moustafa Mijiyawa Rheumatology Department CHU Sylvanus Lomé Togo Rheumatology Department CHU Kara Kara Togo Rheumatology Department CHR Lomé Commune Lomé Togo Rheumatology Department Hopital de Bè Lomé Togo

Background: The reel impact of malignant bone tumors in adults seems unclear in Black Africa. Aim: The aim of this study is to determine the epidemiological and the semiological profile of malignant bone tumors in rheumatology inpatients at Hospital University Center Sylvanus Olympio in Lome. Methods: It was a retrospective study of recorded cases conducted over a period of 19 years in the rheumatology department at Hospital University center Sylvanus Olympio in Lome, Togo. Results: One hundred and sixty-six patients (68 women and 98 men) suffered from a bone tumor. The average age of patients was 55 years old with some extremes cases of 14 and 98 years old. The most affected age group was the one between 46 and 55 years old (40 cases, 24.1%). The disease’s average duration was 17 months. These tumors were primary in 43 cases (26%) and secondary in 123 (74%). Metastases were those of prostate (44 cases, 35.7%), breast (12 cases, 9.7%), bronchus (7 cases, 5.7%), cervix (5.7%), and liver (2 cases, 1.6%). Myeloma (34 cases;79.0%) and osteosarcoma (9 cases;20.9%) were the main primary malignant bone tumors. However, 41 cases (33.3%) of malignant bone tumors had not been able to label. The spine was the predilection part for all above-mentioned tumors. Conclusion: This study shows the significant part occupied by malignant bone tumors in musculoskeletal diseases within the sub-Saharan population in general and Togo in particular.

关键词： bone tumors Rheumatology Africa

Prototyping: Major Advance in Surgical Planning and Customizing Prostheses in Patients with bone tumors of the Head and Neck

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International Journal of Clinical Medicine 2013年第7期4卷 1-7页

作者： Terence PFarias Fernando Luiz Dias Bruno Albuquerque Sousa Mario Sergio Galvao Denio Bispo Ana Carolina Pastl Department of Head and Neck Surgery Brazilian National Cancer InstituteRio de JaneiroBrazil Department of Microsurgery Reconstruction Brazilian National Cancer InstituteRio de JaneiroBrazil.

Major resections of bone tumors of the head and neck, owing to their small dimensions and their proximity to the organs in this region, cause important functional and aesthetic problems that significantly compromise patients’ quality of life. Therefore, therapeutic planning should always extend beyond the resection to include functional and aesthetic reconstruction, preferably immediately. Microsurgical reconstruction represents a significant advance, but has not yet been perfected. Rapid prototyping (RP) comes as a new technology for the purpose of assisting the surgeon in the visual and tactile aspects of surgery, providing diagnostic accuracy and increasing the success of surgical planning. The authors demonstrate the technological advances in the manufacture of customized mandibular prostheses with the assistance of RP and practical applications of these methods.

关键词： Rapid Prototyping bone tumors Head Neck tumors

Multifunctional mesoporous bioactive glass/upconversion nanoparticle nanocomposites with strong red emission to monitor drug delivery and stimulate osteogenic differentiation of stem cells

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Nano Research 2016年第4期9卷 1193-1208页

作者： Fangfang Wang Dong Zhai Chengtie Wu Jiang Chang State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai200050 China

For the therapy and regeneration of bone defects resulting from malignant bone tumors, it is necessary to develop multifunctional biomaterials that are able to deliver therapeutic drugs, monitor drug release, and stimulate bone formation. Herein, a multifunctional mesoporous bioactive glass （MBG）/upconversion nanoparticle （UCNP） nanocomposite [UCNPs@SiO2@mSiO2-XCa （X = 0, 5, 10, 15, and 20）] with the ability to deliver anti-cancer drugs, monitor drug release, and stimulate osteogenic differentiation of bone marrow stromal cells （BMSCs） was successfully prepared using a layer-by-layer strategy. The nanocomposite spheres possess a core--sheU structure composed of UCNPs and a mesoporous SiO2/Ca layer with a uniform size distribution of 100 nm. The incorporation of Ca into the nanocomposites induced phase transformation from a pure hexagonal phase to a cubic phase, and facilitated the occurrence of red emission, which significantly improved fluorescence penetration for deep tissue imaging. In addition, since the red emission strongly overlaps with the maximum absorbance of the anti-cancer drug zinc phthalocyanine （ZnPc）, red luminescence could be strongly quenched by ZnPc. Consequently, drug release could be quantified by monitoring changes in fluorescence intensity. Furthermore, the incorporation of Ca into MBG/UCNP nanocomposites remarkably improved bioactivity, i.e., it stimulated apatite mineralization in simulated body fluids and enhanced cell proliferation and bone-related gene expression in BMSCs for the concentration range of 200-500 ~g/mL. Our results suggest that the prepared MBG/UCNP nanocomposites are useful for the therapy and regeneration of bone defects resulting from malignant bone tumors owing to their distinct multifunctionality, including strong red emission and functions in drug-delivery monitoring and osteostimulation.

关键词： multifunctionalnanocomposites upconversion osteoblastic activity drug release monitoring bone tumors

Calculation of Electromagnetic Field and SAR Dis- tributions of Two Antenna Structures for bone Tu- mors Microwave Hyperthermia

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Journal of Nanjing Medical University 2003年第3期17卷 143-148页

作者：席晓莉汪文秉王丽黎西安交通大学电子与信息工程学院微波工程与光通信研究所西安710049 西安理工大学自动化与信息工程学院电子科学与技术系

Objective: To investigate the electromagnetic field and specific absorptionrate (SAR) distribution of different structure applicators with different depths for treating bonetumors using microwave hyperthermia. Methods: The finite element method (FEM) was used to calculate,electromagnetic field and SAR distribution. Two different structure applicators were simulated. Theone is simple coaxial antenna, which has been successfully used in clinic treating bone tumors inTangdu hospital of the Forth Military Medical University several years. It was formed by a coaxialcable peeled off the out copper at end. The other applicator was coaxial- slot antenna, which waswidely used in microwave hyperthermia. The applicator inserted into the cylindrical bone withdifferent depths, and worked at the frequency of 2 450 MHz. Results: The electric field and SARgenerated by the simple coaxial applicator were mainly concentrated out the tissues, and were notuniform in the tissues, while the coaxial- slot applicator well transmits the electric field and SARinto the tissues, and can easily treat different position by adjusting the slat ***: The results calculated by EFM, were well accordant with the experimental and clinicalresulls, and will be important for improving the clinical effects of microwave hyperthermia.

关键词： bone tumors microwave hyperthermia finite element method electromagnetic field specific absorption rate

Cryoablation of osteoid osteomas:Is it a valid treatment option?

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World Journal of Radiology 2024年第9期16卷 389-397页

作者： Antonios Michailidis Athanasios Panos Efthimios Samoladas Georgios Dimou Georgia Mingou Panagiotis Kosmoliaptsis Maria Arvaniti Christos Giankoulof Evangelos Petsatodis Department of Interventional Radiology Georgios Papanikolaou General Hospital of ThessalonikiThessaloniki 57010Greece Department of 1st Orthopaedic Clinic Georgios Papanikolaou General Hospital of ThessalonikiAristotle University of ThessalonikiThessaloniki 57010Greece Dental School EKPAAthens 15773Greece

BACKGROUND Osteoid osteoma is a benign bone tumor with characteristic clinical *** selected method for its treatment is percutaneous radiofrequency ***,percutaneous cryoablation is an alternative method with certain *** To evaluate percutaneous computed tomography(CT)-guided cryoablation for the treatment of osteoid osteoma in young patients and *** A total of 25 patients were treated with percutaneous CT-guided cryoablation for osteoid osteomas between October 2020 and March 2023 at a single *** patients were above 14-years-old(mean age,24-years-old),and all procedures were performed under local *** the 25 patients,8 were female and 17 were *** sites included the femur(n=9),medial malleolus(n=4),sacral ala(n=4),facets(n=4),humerus(n=3),and tibia(n=1).One cryoprobe was used in each procedure and,when possible,the lesion was covered by the ice-ball using an extraosseous position without penetrating the *** necessary thermal protective techniques were used depending on the anatomical structure at *** All patients treated had complete response(100%clinical success rate)starting on the day of the *** success was achieved in all *** analog scale(VAS)scores at 1 year were 0,compared to a mean VAS score of 8.5±1(SD)before the *** recurrences were reported at the 1-year follow-up and no complications were *** 11/25 cases,an extraosseous position of the cryoprobe was used with less procedural time achieving technical and clinical success and no complications with less patient *** patients were discharged from the hospital on the same day as the *** Cryoablation of osteoid osteomas is an efficacious and safe procedure with durable clinical *** greatest advantage is that the procedure can be performed under local anesthesia using an extraosseous position of the cryoprobe when possible.

关键词： Cryoablation Osteoid osteoma Computed tomography guidance Interventional radiology Orthopedics bone tumors