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Meta-analysis of Randomized Controlled Clinical Studies on Effect of Salmon Calcitonin on bone pain in Osteoporosis Patients

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Medicinal Plant 2024年第4期15卷 86-88,98页

作者： Fengjuan MAO Chengmei MAO Hongxia CHENG No.2 Department of Orthopaedics Taihe Hospital Affiliated to Hubei University of MedicineShiyan 442000China

[Objectives]To systematically evaluate the efficacy and safety of salmon calcitonin in the treatment of osteoporosis,and to provide reference for clinical salmon calcitonin treatment and improvement of bone pain symptoms of osteoporosis.[Methods]Randomized controlled trials(RCTs)of salmon calcitonin in the treatment of osteoporosis from January 2000 to March 2015 were collected by searching Chinese Biomechanics Literature Database(SinoMed,CBM),China National Knowledge Infrastructure(CNKI),VIP and Wanfang *** relevant data of bone pain degree and bone mineral density were extracted to evaluate the methodological ***-analysis was performed using RevMan 5.1 software.A total of 13 randomized controlled trials involving 1683 patients were included,including 862 patients in the observation group and 821 patients in the control group.[Results]Meta-analysis showed that salmon calcitonin combined with calcium was better than the control group in improving bone pain symptoms in osteoporosis patients,and the difference was statistically significant[RR=1.84,95%CI(1.56,2.18)].[Conclusions]The salmon calcitonin can significantly improve the bone pain symptoms of the osteoporosis patients,and has no serious adverse ***,due to the small number of studies included in this systematic review and the small sample size,it still needs to be confirmed by high-quality,large sample,multi-center randomized controlled trials.

关键词： Salmon calcitonin Osteoporosis bone pain Meta-analysis

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Chronic Recurrent Multifocal Osteomyelitis (CRMO): An Unusual Presentation of Limb pain

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Open Journal of Pediatrics 2022年第3期12卷 522-528页

作者： Khadiza Tul Qubra Mujammel Haque Mohammad Imnul Islam Shahana Rahman Department of Pediatrics Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh

Chronic recurrent multifocal osteomyelitis (CRMO), known as nonbacterial osteomyelitis, is an autoinflammatory disease with periodic exacerbations, also known as nonbacterial osteomyelitis. It is a rare, noninfectious inflammatory disorder characterized by multifocal bony lesions with pain. Conventional X-ray and CT imaging show multiple osteolytic and sclerotic lesions in the affected limbs. It is a great challenge for pediatricians to diagnose this disease for its rarity. Early diagnosis, regular follow-up and appropriate treatments are mandatory to reduce morbidity and prevent these disease complications. We report here two cases of CRMO who presented with pain, swelling and redness of multiple sites of lower limbs from the Department of Paediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU). Clinical features, laboratory findings, and characteristic radiological findings were strongly suggestive of CRMO.

关键词： bone pain CRMO Multifocal Osteomyelitis

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