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Repair of the radial defect of rabbit with polyester/tricalcium phosphate scaffolds prepared by rapid prototyping technology

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Chinese Journal of Traumatology 2006年第5期9卷 298-302页

作者：孙梁胡蕴玉熊卓王万明潘屿 Department of Orthopeadics Fuzhou General HospitalFuzhou 350025China Orthopedics Institute of PLA Xijing HospitalFourth Military Medical UniversityXi'an 710032 China Department of Mechanical Engineering Tsinghua UniversityBeijing 10084 China

Objective： To evaluate the effects of repairing rabbit radial defects with polyester/tricalcium phosphate scaffolds prepared by rapid prototyping technology loaded with bovine bone morphogenetic protein （ bBMP）, and find new carriers for growth factors. Methods： Polyester/tricalcium phosphate scaffolds prepared by rapid prototyping technology loaded with and without bovine BMP were used to repair the 15 mm radial defect in rabbit. Then the results of radiography, histology, scaffolds degrade rates and bone mineral density （BMD） were appraised to examine the effects at the 12th week. Results ： At the 12th week postoperatively, all defects treated with bBMP were radiographically repaired. No radius implanted polyester/tricalcium phosphate scaffolds without bBMP showed radiographic and histological union. At experimental groups, longitudinal alignment of lamellar structure was observed histologically at the 12th week,indicating that remodeling of regenerated bone was complete in different degree. Of the three experimental groups, the bony regeneration and remodeling of callus in poly lactide-co-glycolide/tricalcium phosphate （PLGA/ TCP） group was the best. The BMD values were beyond 70% of normal value at the 12th week while the PLGA/ TCP scaffolds group was the highest, and no abnormalities were observed in the surrounding soft tissue in all groups. Conclusions - Polyester/tricalcium phosphate scaffolds prepared by rapid prototyping technology loaded with bovine BMP can repair a 15 mm radial defect of rabbit. As for the results, the PLGA/TCP scaffold is ideal and better than poly L-lactide-co-D, L-lactide （ PDLLA/TCP ） scaffold, but the ploy L-lactic acid （PLLA/TCP） is not so good for its low degradation rates.

关键词： Polyester : Tricalcium phosphate bone density

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Study of Raloxifene,Zoledronic acid,Alendronate and Calcitonin on type 2 diabetes combined with type Ⅰ osteoporosis Macroadenomas

Study of Raloxifene,Zoledronic acid,Alendronate and Calciton...

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2016年浙江省医学会营养与代谢分会第二届学术年会暨老年营养与代谢疾病诊治新进展研讨会

作者： Zhouhong Mao Kai Zhou Guangwu Zhang Fengqin Dong Xuewen Jia Junwu Shi Department of Endocrinology Ningbo First Hospital Department of Endocrinology Ningbo Hospital of TCM Department of Endocrinology Ningbo Medical Treatment Center Lihuili Hospital Department of Endocrinology the First Affiliated HospitalZhejiang University Department of Osteology Ningbo First Hospital Department of Osteology Wenzhou Second Hospital

The aim of this study was to observe the efficacy of Raloxifene,Zoledronic acid,Alendronate and salmon calcitonin on type 2 diabetes combined with type 1 osteoporosis.108 patients were randomly divided into four groups,and group A was given oral Raloxifene(60 mg/d);group B was administrated salmon calcitonin nasal spray(dose:200 IU/d);group C was given oral Alendronate(70 mg/w),and the duration of above three groups was 24 ***,group D was injected with 5 mg of Zoledronic acid *** on the baseline survey,change rate of lumbar spine and hip bone mineral density(BMD) from baseline to end point was *** with pre-treatment,lumbar spine(1-4) and hip bone mineral density were significantly improved after the treatment in four groups(Pbone mineral density in type 2 diabetic with type 1 osteoporosis,and the efficacy of Raloxifene and Alendronate was better than Calcitonin,but poorer than Zoledronic ***,four therapeutic regimes were safe and well tolerated.

关键词： Type 2 diabetes mellitus type 1 osteoporosis raloxifene zoledronic acid alendronate and calcitonin bone density

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Effects of Qing'E Formula on the Expression of bone Metabolic Markers and VDR mRNA in Postmenopausal Osteoporosis Patients

Effects of Qing'E Formula on the Expression of Bone Metaboli...

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中国中西医结合学会诊断专业委员会第十三次全国学术研讨会

作者： Bo Shuai Yan Ping Yang Lin Shen Hui Ke Department of Integrated Traditional Chinese and Western Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology

Objective To study the partial mechanism of treating postmenopausal osteoporosis patients(POPs) using the ancient recipe of Qing’E formula(QEF) by observing its effects on bone metabolic markers and VDR m RNA expression in primary POPs. Methods Analysis was performed on 120 outpatient and inpatient POPs treated in our hospital between January and October 2013, where the patients were randomly divided into Qing’E group(QEF+ Caltrate), Calcitriol group(Caltrate + Calcitriol soft capsules), and compare group(Caltrate), each with an follow-up period of 1 year. Statistical analysis was then performed on bone mineral density, blood bone metabolic markers(β-CTX, N-MID, T-PINP) and changes in VDR m RNA expressions in the POPs before and after the treatments. Results Prior to the treatments, bone mineral density and blood β-CTX, N-MID, T-PINP and VDR m RNA expression in the 3 groups of POPs exhibited no statistically significant differences, and the blood β-CTX, N-MID, T-PINP and VDR m RNA expression in the control group showed no statistically significant differences before and after the treatments. There were no significant differences in bone mineral density in the Qing’E group and the Calcitriol group before and after the treatments whereas the bone mineral density decreased in the control group after the treatments. As for blood β-CTX, N-MID, T-PINP and VDR m RNA expression, the measurements in POPs in the Qing’E group and the Calcitriol group were significantly higher than that of the control group’s. Conclusion By adjusting the VDR m RNA expression, the QEF, a kidney-invigorating Chinese herbal formula, is capable of activating bone metabolism to prohibit further losses of bone mass, thereby preventing the deterioration of osteoporosis.

关键词： Qing’E formula VDR mRNA osteoporosis bone metabolism bone density

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Clinical observation on acupuncture for male osteoporosis

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World Journal of Acupuncture-Moxibustion 2011年第3期21卷 26-29页

作者：欧阳钢王东岩徐小梅江苏省省级机关医院康复医学科江苏省连云港市第一人民医院

Objective To compare the therapeutic effects of acupuncture combined with drug and simple drug for treatment of male osteoporosis. Methods Fifty-five cases were divided into a comprehensive therapy group （observation group, 25 eases） and a medication （control group, 30 cases） randomly. The observation group was treated with acupuncture and moxibustion at Pishu （脾俞BL 20）, Shenshu （肾俞 BL 23）, Mingmen （命门 GV 4）, Shenque （神阙 CV 8） and so on combined with oral administration of Alendronate, while the control group was treated with oral administration of Alendronate simply. The improvement of both Integral of Clinical Symptoms （ICS） and bone Mineral density （BMD） of two groups were observed after 6 months treatment. Results The ICS of two groups after treatment both decreased significantly （both P〈0.001）, and the decreasing degree in observation group was more significant than that in control group （P〈0.001）. The BMD of lumbar vertebrae and femur in observation group increased obviously than that before treatment （P〈0.01, P〈0.05）. The increasing degree of BMD of lumbar vertebrae in observation group after treatment was more obvious than that in control group （P〈0.05）. There were abdominal pain, diarrhea, nausea, vomiting, dyspepsia and other adverse reaction in control group, while the degree and occurrence rate of those in observation group alleviated and decreased obviously. Conclusion The effect of acupuncture combined with drug for male osteoporosis is good with little adverse reaction. This method is better than taking Alendronate.

关键词： Osteoporosis, Male Acupuncture-Moxibustion bone density

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Comparative study of 99Tc-MDP and zoledronic acid in the treatment of osteoporosis

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Journal of Hainan Medical University 2020年第16期26卷 35-39页

作者： Ying Zhou Wei-Min Pan Wen Sun Chao-Qun Wang Juan-Juan Yan Quan Xie YingHuang Huan Xiao Wei-Wen Yan Department Of Nuclear Medicine The First Affiliated Hospital of Hainan Medical UniversityHaikou 570102China Department Of Nuclear Medicine Hainan General HospitalHaikou 570102China

Objective:To compare the efficacy and mechanism of zoledronic acid and Tc-MDP in the treatment of ***:From July 2011 to November 2015,232 patients with primary osteoporosis were selected and treated in The First Affiliated Hospital of Hainan Medical College were selected and were divided into the 116 patients in the Tc-MDP group and 116 patients in the zoledronic acid group accorded to the treatment *** zoledronic acid group were given zoledronic acid treatment,1 time in one *** Tc-MDP group were given Tc-MDP treatment,and the treatment were treated for 10 days for 1 course,1 course for 3 months,and a total of 3 years of treatment were *** prognosis and the changes of bone mineral density and hematological parameters were ***:The total effective rates of the zoledronic acid group and Tc-MDP group were 99.1%and 90.0%,respectively,and the zoledronic acid group were significantly higher than the Tc-MDP group(Pbone mineral density of lumbar vertebrae and hip after treatment were significantly higher than that of the two groups before treatment,and the zoledronic acid group were also significantly higher than the Tc-MDP group(P0.05),and the erythroeyte sedimentation rate(ESR)levels were lower than before treatment(Pbone density,relieve joint tenderness symptoms,reduce ESR content,and will not affect patients'blood calcium and blood phosphorus ***,zoledronic acid increases

关键词： Zoledronic acid Tc-MDP Osteoporosis Erythrocyte sedimentation rate bone density

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2013版“美国放射学院关于定量CT(QCT)骨密度测量操作指南”解读

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中国骨与关节杂志 2014年第11期3卷 835-837页

作者：李娜程晓光北京积水潭医院放射科 100035

美国放射学院(the American college of radiology,ACR)是一个以放射学家、放射肿瘤学家以及临床医学物理学家为主体的专业协会,拥有超过30 000名成员。学院会周期性地为放射学实践拟定新的实践指南和技术标准来促进全美放射学发展和服... 详细信息

美国放射学院(the American college of radiology,ACR)是一个以放射学家、放射肿瘤学家以及临床医学物理学家为主体的专业协会,拥有超过30 000名成员。学院会周期性地为放射学实践拟定新的实践指南和技术标准来促进全美放射学发展和服务质量的提高。每一个实践指南和技术标准都经过了广泛地审查和批准,旨在帮助医生为患者提供适当的放射学服务。它为临床医师提供可参考的指导原则,但不是硬性的规定、标准或限制。

关键词： bone density Tomography,X-ray Osteoporosis Quantitative computed tomography

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定量CT测量近段股骨骨密度及骨皮质的研究进展

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中国骨与关节杂志 2014年第11期3卷 838-842页

作者：王玲马毅民程晓光北京积水潭医院放射科 100035 南方医科大学珠江医院影像科

髋关节脆性骨折是最严重的脆性骨折,给老年人的行动、独立生活和生活质量带来很大不良影响,导致了老年人的病死率上升[1-2]。随着人口老龄化,髋关节骨折发病率逐年上升,预计世界范围内髋关节骨折发生数量将从1990年的170万增加到2050年... 详细信息

髋关节脆性骨折是最严重的脆性骨折,给老年人的行动、独立生活和生活质量带来很大不良影响,导致了老年人的病死率上升[1-2]。随着人口老龄化,髋关节骨折发病率逐年上升,预计世界范围内髋关节骨折发生数量将从1990年的170万增加到2050年的630万[3]。髋关节发生脆性骨折主要因其力学性能发生变化,而这种变化与多种因素有关,包括骨密度(bone mineral density,BMD)。

关键词： Tomography,X-ray bone density Hip fractures Femur Femur neck

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