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bone MINERAL ANALYSIS OF WHOLE BODY IN 292 NORMAL SUBJECTS ASSESSED BY DUAL X-RAY ABSORPTIOMETRY

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Chinese Medical Sciences Journal 2003年第2期18卷 97-99页

作者：秦明伟余卫徐苓田均平邢小平孟迅吾 Department of Radiology Reking Union Medical College HospitalCAMS & PUMCBeijing 100730

Objective. To study the whole body bone mineral changes in normal ***. bone mineral was measured by dual X-ray absorptiometry(DXA) in 292 normal subjectsaged 10～79 years, including 152 females and 140 males. They were divided into age-groups by ***. In males, the ages with peak value of total bone mineral content (TBMC), total bone min-eral density (TBMD), anteroposterior spine BMD(L2-4 BMD) were in the 30～39,20～39, 20～29 age-groups respectively. In females, they were all in the 30～39 age-group. Peak values of TBMC, TBMD,L2-4 BMD were higher in males than those in females. Loss of bone mineral for females was more pro-nounced than that for males. Loss of L2-4 BMD was more pronounced than ***. This study provides the normal bone mineral data of whole body for males and females,and the characteristic of changes.

关键词： osteoporosis bone density dual X-ray absorptiometry whole body

Therapeutic Efficacy Observation on Acupuncture for Postmenopausal Osteoporosis

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Journal of Acupuncture and Tuina Science 2013年第3期11卷 151-154页

作者： Du Ge-shu Acupuncture Department Changsha Hospital of Traditional Chinese Medicine

Objective: To observe the clinical efficacy of acupuncture for post- menopausal osteoporosis (PMOP). Methods: A total of 64 PMOP cases were randomized into an observation group and a control group, 32 cases in each group. Acupuncture was employed in the observation group, versus oral Osteoform capsule in the control group. After 3-month treatment, the bone density (BD) and Estradiol (E 2 ) were measured respectively before and after treatment, followed by statistical analysis on clinical efficacies in the two groups. Results: The total effective rate of the observation group was 81.3%, showing a statistical difference compared with the control group (P0.05). Conclusion: Acupuncture has exact efficacy for PMOP and is therefore effective for the prevention and treatment of PMOP.

关键词： Acupuncture Therapy Osteoporosis, Postmenopausal bone density Estradiol

Role of dual energy X-ray absorptiometry in monitoring fracture healing in a rat femoral fracture model

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Chinese Journal of Traumatology 2005年第2期8卷 121-125页

作者：李伟赵光锋徐少文王建卫周一飞刘健 Department of Orthopaedics Second Affiliated Hospital Medical College Zhejiang University Hangzhou 310009 China

Objective: To dynamically monitor the bone mineral density (BMD) and the histomorphological changes during fracture healing in a rat femoral fracture model and to explore the role of dual energy X-ray absorptiometry (DEXA) in evaluating bone fracture healing. Methods: Sixty three-month-old female Sprague Dawley rats were used to establish right femoral fracture models. The BMD of the callus of the fractured right femur were scanned by DEXA at 2, 4, 6, 8, 10 and 12 weeks after operation, respectively. A light microscope was used to evaluate the callus of each rat at the same time. The corresponding segment of the left femur was taken as a control. Results: The BMD at the fractured site increased significantly during the process of facture healing, which shows an obvious healing trend. The callus BMDs were 29.5%, 48.3%, 85.3%, and 105.2% of the BMD of the control limb at 2, 4, 6 and 8 weeks after fracture, respectively. There was a significantly difference between the groups. A compatibility on time was found between the BMD and the histomorphological characteristics at the fractured site during the process of fracture healing. The fracture healing was almost completed at 8 weeks after fracture as assessed by its histomorphological characteristics when the callus BMD reached to 105.2% of the BMD of the control limb. The BMD of the distal metaphysis decreased until 12 weeks after fracture. Conclusions: DEXA can evaluate the mineralization of the callus during the facture healing process accurately and quantitatively and is more sensitive than plain radiography in detecting impaired bone unions, which indicates that it may play an important role in monitoring fracture healing.

关键词： Densitometry, X-ray Fracture healing bone density Histology Rats

Clinical update of pulsed electromagnetic fields on osteoporosis

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Chinese Medical Journal 2008年第20期121卷 2095-2099页

作者： HUANG Li-qun HE Hong-chen HE Cheng-qi CHEN Jian YANG Lin Department of Rehabilitation Medicine West China Hospital Affiliated to Sichuan University Chengdu Sichuan 610041 China

Objective To understand the effects of low-frequency pulsed electromagnetic fields （PEMFs） on chronic bony pain, bone mineral density （BMD）, bone strength and biochemical markers of bone metabolism in the patients of osteoporosis. Data sources Using the key words “pulsed electromagnetic fields” and “osteoporosis”, we searched the PubMed for related studies published in English from January 1996 to December 2007. We also searched the China National Knowledge Infrastructure （CNKI） for studies published in Chinese from January 1996 to December 2007.Study selection Inclusion criteria：（1） all articles which referred to the effects of low-frequency pulsed magnetic fields on osteoporosis either in primary osteoporosis or secondary osteoporosis; （2） either observational studies or randomized controlled studies. Exclusion criteria：（1） articles on experimental studies about osteoporosis; （2） repetitive studies; （3） case reports; （4） meta analysis.Results Totally 111 related articles were collected, 101 of them were published in Chinese, 10 were in English. Thirty-four were included and the remaining 84 were excluded.Conclusions Low-frequency PEMFs relieves the pain of primary osteoporosis quickly and efficiently, enhances bone formation and increases BMD of secondary osteoporosis. But the effects of PEMFs on bone mineral density of primary osteoporosis and bone resorption were controversial.

关键词： pulsed electromagnetic fields osteoporosis pain bone density biochemical markers of bone metabolism

Clinical manifestations of low bone mass in amenorrhea patients with elevated follicular stimulating hormone

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Chinese Medical Journal 2002年第9期115卷 1376-1379,153页

作者：郁琦林守清何方方李包罗林元张涛张颖中国医学科学院中国协和医科大学北京协和医院妇产科北京100730 福建医院福州350001

OBJECTIVE: To study the characteristics of low bone mass in amenorrhea patients with elevated follicular stimulating hormone (FSH). METHODS: Amenorrhea patients with elevated FSH: Primary amenorrhea 18 cases, secondary amenorrhea 171 cases and age matched controls with normal menstruation, 180 cases. The descriptive parameters were: estrogen, alkaline phosphatase, urinary excretion of calcium to creatine ratio, cortical bone mineral density at the right radius measured by single photon absorptiometry and trabecular bone mineral density at the lumbar vertebra body measured by quantitative computerized tomography. RESULTS: Average E(2) levels in amenorrhea patients is under 150 pmol/L with significantly higher alkaline phosphatase and urine calcium to creatine ratio values than the normal menstruation group. Cortical bone mineral density in the secondary amenorrhea group (655 +/- 69 mg/cm(2)) was significantly lower than that of the normal menstruation group (677 +/- 56 mg/cm(2), P

关键词： bone density Adult Age Factors Amenorrhea bone and bones Estradiol Female Follicle Stimulating Hormone Humans Menopause Middle Aged

Prevalence rate of osteoporosis in the mid-aged and elderly in selected parts of China

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Chinese Medical Journal 2002年第5期115卷 773-775,159页

作者：李宁华区品中朱汉民杨定焯郑蘋如卫生部北京医院流行病学研究室北京100730 广州医学院附二院骨科广州510260 上海华东医院上海200040 华西医科大学附四院骨质疏松科成都610041 白求恩医科大学附一院干部病房长春130021

OBJECTIVE: To understand the distribution of prevalence rate of osteoporosis in the middle - aged and elderly in parts of China. METHODS: bone mineral density (BMD) was measured and questionnaires were taken for 5593 people aged above 40 years in five administrative areas in China selected by the stratified - multi - steps - cluster sampling method. RESULTS: The total prevalence rate of osteoporosis was 16.1%. The prevalence rate among males was 11.5% and among females was 19.9% (P

关键词： Adult Age Factors Aged Aged, 80 and over bone density China Female Geography Humans Male Middle Aged Osteoporosis Prevalence Research Support, Non-U.S. Gov't Rural Health Sex Factors Urban Health

Treatment of osteoporosis in men using dehydroepiandrosterone sulfate

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Chinese Medical Journal 2002年第3期115卷 402-404页

作者：孙宜萍毛敏伟孙丽华冯缨缨杨建芬沈佩华上海市第六人民医院老年科上海200233

OBJECTIVE: To study the effect of dehydroepiandrosterone sulfate (DHEAS) treatment of osteoporosis in men with T(BMD) > or = 2.5SD. METHODS: Eighty-six patients were randomly divided into two groups: treatment group (n = 44) and control group (n = 42). DHEAS (100 mg q.d.) was given to the treatment group for 6 months. bone mineral density, (BMD), biochemical markers of bone absorption and formation and other serum biochemical markers were measured before and after DHEAS treatment. Drug side effects were also evaluated. RESULTS: After oral administration of DHEAS (100 mg q.d.) for 6 months, the serum concentrations of DHEAS and IGF-I in the treatment group were 93.75% +/- 16.1% and 17.71% +/- 4.2% higher respectively than those in the control group (P

关键词： Aged Aged, 80 and over bone density Dehydroepiandrosterone Sulfate Humans Male Middle Aged Osteoporosis Research Support, Non-U.S. Gov't

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Feasibility of vertebral internal fixation using deer and sheep as animal models

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Chinese Medical Journal 2010年第17期123卷 2379-2383页

作者： LIU Guo-min, LI You-qiong, XU Chuan-jie, ZHU Xiao-min and LIU Yi LIU Guo-min LI You-qiong XU Chuan-jie ZHU Xiao-min LIU Yi Department of Orthopedics Second Hospital of Jilin University Changchun Jilin 130041 China Department of Pathology Second Hospital of Jilin University Changchun Jilin 130041 China Department of Gastroenterology Second Hospital of Jilin University Changchun Jilin 130041 China Basic Medical Department of Jilin University Changchun Jilin 130041 China

Backgroud Studies on new vertebral internal fixations of animals are very important prior to clinical application. This study aimed to determine the feasibility of vertebral internal fixation on morphologic and biomechanical properties using deer and sheep as animal models and comparing to human *** Thirty sets of fresh Sika deer lumbar, 30 sets of fresh sheep lumbar, and 20 sets of fresh lumbar from male cadavers were used. We examined the morphology of the centra and pedicles of the three groups, and determined the cancellous bone density and biomechanical properties in all *** There were marked differences in all parameters measured between the different species. The sizes of the upper, middle, and lower transverse diameter were largest in the human, followed by the deer, then the sheep. The index of centrum transverse diameters and sagittal diameters were less than 0.8 （a triangle）, and the deer was more similar to the human. The heights of the right vertebral pedicles and the anterior disc heights （IDH） were largest in the human, followed by the deer, then the sheep. The apparent density, elastic modulus, and ultimate load were largest in the sheep, followed by the deer, then the human. The range of motion （ROM） of functional lumbar units （FLUs） with a combined flexion-extension moment was largest in the human, followed by the deer then the sheep. Conclusions The deer lumbar is more similar to that of human in anatomical form and biomechanics than the sheep lumbar. As such, deer is more appropriate as an animal model for use in vertebral internal fixation studies.

关键词： deer sheep lumbar morphology bone density biomechanics

Percutaneous estrogen in prevention of early postmenopausal bone loss in Chinese women

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Chinese Medical Journal 2002年第12期115卷 1790-1795页

作者：孙爱军林守清余卫秦明伟陈凤领张颖魏扬 Bruno de Lignieres 北京协和医院妇产科北京100730 北京铁路医院北京100038 NeckerHospital

OBJECTIVE: To identify the optimal dosage of 17beta-estradiol gel + oral progestin for preventing bone loss in postmenopausal Chinese women. METHODS: A 3-year open label, randomized, prospective clinical trial was conducted. Sixty healthy women who had been postmenopausal for 1 to 5 years were recruited and divided into following 4 groups: group 1, percutaneous gel 17beta-estradiol (E(2)) 1.5 mg/d plus micronized progesterone (MP) 100 mg/d; group 2, percutaneous gel 17beta-estradiol (E(2)) 1.5 mg/d plus medroxyprogesterone acetate (MPA) 2 mg/d; group 3, percutaneous gel 17beta-estradiol (E(2)) 0.75 mg/d plus micronized progesterone (MP) 100 mg/d; and group 4, percutaneous gel 17beta-estradiol (E(2)) 0.75 mg/d plus medroxyprogesterone acetate (MPA) 2 mg/d. Estrogen and progestin were given continuously for 25 days per month. bone mineral density (BMD) was measured using quantitative computed tomography (QCT) for trabecular bone of L2-5 and dual energy X-ray absorptiometry (DEXA) for L2-4 and hip 5 times during the trial at baseline and at the 6-, 12-, 18-, 24- and 36-month visits. RESULTS: Fifty-nine patients (98.3%, 59/60) stayed in the study for 1 year, 56 patients (93.3%, 56/60) for 2 years, and 51 (85%, 51/50) for 3 years. On average, menopausal symptoms were relieved by 80% after 6 months of treatment. By the 24th month, the mean increase in BMD ranged from 4.3% to 7.5% in trabecular bone; and by the 36th month, it ranged from 4.2% to 6.2% in L2-4 and 1.61% to 3.77% in the neck. There were significant difference after treatment (P 0.05) was found in improvement of symptoms, levels of bone markers or BMD. CONCLUSION: A daily dose of estradiol gel, either 0.75 mg or 1.5 mg, is effective in preventing early postmenopausal bone loss and relieving menopausal symptoms. After 3-year treatment, spinal BMD could increase steadily, so does hip BMD, especially in the first 2 years.

关键词： Administration, Cutaneous Adult bone density Estradiol Estrogen Replacement Therapy Female Fractures, bone Humans Medroxyprogesterone 17-Acetate Middle Aged Osteoporosis, Postmenopausal