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bone density, microarchitecture and stiffness in Caucasian and Caribbean Hispanic postmenopausal American women

bone Research 2014年第3期2卷 194-202页

作者： Bin Zhou Ji Wang Emily M Stein Zhendong Zhang Kyle K Nishiyama Chiyuan A Zhang Thomas L Nickolas Elizabeth Shane X Edward Guo bone Bioengineering Laboratory Department of Biomedical Engineering Columbia University Division of Endocrinology Department of Medicine Columbia University Department of Orthopedic Surgery First Affiliated Hospital School of Medicine Shihezi University

Hispanic Americans of Caribbean origin are a fast-growing subset of the US population, but there are no studies on bone density, microstructure and biomechanical integrity in this minority group. In this study, we aimed to compare Caucasian and Caribbean Hispanic postmenopausal American women with respect to these characteristics. Thirty-three Caribbean Hispanics were age-matched to thirty-three Caucasian postmenopausal women. At the lumbar spine, the Hispanic women had significantly lower areal bone mineral density （aBMD）. At the radius by high-resolution peripheral quantitative computed tomography （HR-pQCT）, there were minimal differences between Hispanic and Caucasian women. At the tibia, Hispanic women had lower trabecular volumetric bone density and trabecular number, and higher trabecular separation. Individual trabecula segmentation （ITS） analyses indicated that at the tibia, Hispanic women not only had significantly lower bone volume fraction, but also had significantly lower rod bone volume fraction, plate trabecular number, rod trabecular number and lower plate-plate, plate-rod and rod-rod junction densities compared to Caucasian women. The differences in bone quantity and quality contributed to lower whole bone stiffness at the radius, and both whole bone and trabecular bone stiffness at the tibia in Hispanic women. In conclusion, Hispanic women had poorer bone mechanical and microarchitectural properties than Caucasian women, especially at the load-bearing distal tibia.

关键词： bone DXA bone density microarchitecture and stiffness in Caucasian and Caribbean Hispanic postmenopausal American women

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Pelvic region bone density,soft tissue mass,and injury frequency in female professional ballet dancers and soccer athletes

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Sports Medicine and Health Science 2021年第3期3卷 157-164页

作者： Hamed Vahedi Carter M.Taft Joshua R.Daum Sherif Dabash Patrick C.McCulloch Bradley S.Lambert Department of Orthopedics&Sports Medicine Houston Methodist HospitalHoustonTXUnited States Department of Kinesiology Rice UniversityHoustonTXUnited States

We recently observed a high prevalence of low pelvic bone mineral density(BMD)in female professional ballet *** this population is susceptible to musculoskeletal overuse injuries,we aimed to determine which regions of the pelvis may be at greatest risk compared to general population females(GENPOP)as well as professional female soccer players(SOCCER,a comparison to other elite athletes regularly subjected to high degrees of loading).Three groups of age-matched females[(GENPOP;n=38,27±1yrs),(BALLET;single com-pany,n=36,26±3yrs),(SOCCER;single NWSL■club,n=34,25±1yrs)]consented to have their BMD and body composition assessed(DEXA,GE■).In addition to soft tissue and total and regional BMD analyses,a segmental analysis of the pelvis was performed to determine site-specific BMD for the iliac fossa,iliac fossa/iliac crest/ilium combined,pubic bone,ischium,and sacrum.A mixed-model ANOVA followed by a Tukey's post-hoc test was used to compare the groups(Type-I error;α=0.05).The BALLET group had lower pelvic BMD for all measures(Avg.%Diff.=15%-27%,p<0.001)compared to the SOCCER group and for the ischium(Avg.%Diff.=8%;p=0.007)and sacrum(Avg.%Diff.=7%;p=0.028)compared to the GENPOP *** BALLET group had lower lean mass for all measures compared to the other groups(Avg.%Diff.=12%-18%;p<0.01).Professional ballet performers exhibit reduced pelvic region soft tissue and site-specific BMD not previously detected using standard DEXA *** findings highlight which pelvic regions may benefit from preventative strength training and/or nutritional interventions.

关键词： Ballet bone bone density Athlete Female athlete

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Analysis of the Spatial Distribution Characteristics of Abnormal bone density in Male Long-Distance Runners from Different Regions in China

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Open Journal of Epidemiology 2021年第1期11卷 80-91页

作者： Longxing Fan Wenjie Zhang Huanhuan Cui Yanqing Liu Ziquan Liu Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety College of Chemistry Fuzhou University Fuzhou China Tianjin Center for Disease Control and Prevention Tianjin China Institute of Disaster Medicine Tianjin University Tianjin China

Objective: To investigate the occurrence pattern of abnormal bone density in male long-distance runners from several different regions of China, and provide a basis for elucidating the influences of geo-environmental differences on bone density. Methods: We employed a set of well-designed exclusion-inclusion criteria to recruit study subjects, in which compounding factors were managed and regional environmental traits were fully incorporated. WHO (World Health Organization) criteria for the diagnosis of osteoporosis were then used to examine the subjects to determine occurrence of abnormal bone density. The resulting data were analyzed using methods of spatial statistics, which included several approaches, such as spatial autocorrelation, hot spot analysis, and Geodetector Software analysis, to depict and analyze the spatial distribution of abnormal bone density in male athletes from different regions in China, thereby investigating the influences of geo-environmental factors (e.g., temperature, humidity, and altitude) on bone density. Results: A total of 685 subjects were effectively examined in this study, including 486 with normal bone density, 185 with osteopenia, and 14 with osteoporosis. Spatial distribution analysis revealed that the distribution of subjects with abnormal bone density overall exhibited a pattern indicating that the level of abnormal bone density in the eastern regions was higher than that in the western regions and that the levels of abnormal bone density in the southern and northern regions were higher than that in the middle regions. Spatial autocorrelation analysis revealed a Moran’s I = 0.136, Z-score = 1.114, and P value = 0.265 and indicated that the athletes with abnormal bone density were randomly distributed in each region. Hot spot analysis revealed that Tibet and Qinghai displayed distributions of cold spots. Geodetector Software analysis yielded a Q<

关键词： Spatial Epidemiology Regions Athletes bone density

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Association of polymorphisms in low-density lipoprotein receptor-related protein 5 gene with bone mineral density in postmenopausal Chinese women

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Acta Pharmacologica Sinica 2005年第9期26卷 1111-1116页

作者： Zhen-lin ZHANG~2 Yue-juan QIN Jin-wei HE Qi-ren HUANG Miao LI Yun-qiu HU Yu-juan LIU Center for Preventing and Treating Osteoporosis,Osteoporosis Research Unit,the Sixth People’s Hospital,Shanghai Jiaotong University,Shanghai 200233,China Center for Preventing and Treating Osteoporosis Osteoporosis Research Unit the Sixth People's Hospital Shanghai Jiaotong University Shanghai China

Aim:To investigate the possible association of Q89R,N740N and A1330V poly-morphisms in low-density lipoprotein receptor-related protein 5(LRP5)gene withbone mineral density(BMD)in postmenopausal Chinese ***:Q89R,N740N and A1330V genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)in 647 unrelated healthypostmenopausal Han Chinese women aged 43-76 years in *** atlumbar spine 1-4 and the left proximal femur including the femoral neck,trochanterand Ward’s triangle were measured by dual-energy X-ray absorptionmetry in ***:The distribution of the Q89R,N740N and A1330V genotypesin this population was as follows:QQ 80.5%,QR 18.7%,and RR 0.8%;TT 66.9%,TC 31.1%,and CC 2.0%;AA 68.0%,AV 29.7%,and VV 2.3%.The frequencies of theQ89R,N740N and A 1330V genotypes and alleles did not deviate from the Hardy-Weinberg *** found that the Q89R and A1330V polymorphisms werein linkage disequilibrium in our population(x~2=13.50,P<0.01).Both before and afteradjusting for age,years since menopause,height,and weight,the Q89R or N740Ngenotypes were significantly associated with BMD at the femoral neck(P<0.05).Subjects with the Q89R QQ genotype or the N740N TT genotype had a signifi-cantly higher BMD at the femoral neck,compared with those with the QR/RR orTC/CC genotypes,*** significant association was found betweenA1330V polymorphism and BMD at any ***:Our findings suggestthat the LRP5 gene is a candidate for the genetic determination of BMD in post-menopausal Chinese women.

关键词： bone density low-density lipoprotein receptor-related protein 5 polymorphism

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Reduced bone mineral density and altered bone turnover markers in patients with non-cirrhotic chronic hepatitis B or C infection

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World Journal of Gastroenterology 2005年第12期11卷 1843-1847页

作者： Ingolf Schiefke Andreas Fach Marcus Wiedmann Andreas V.Aretin Eva Schenker Gudrun Borte Manfred Wiese Joachim Moessner Department Department of Radiology Department of Internal Medicine Ⅱ

AIM: Previous studies suggest that loss of bone mineral density (BMD) frequently occurs in patients with chronic viral liver disease, presenting with histologically proven liver cirrhosis. However, little is known about the occurrence of bone disease in non-cirrhotic patients with chronic hepatitis B or C. Therefore, it was the aim of this study to evaluate this particular population for BMD and bone turnover markers. METHODS: Biochemical markers of bone turnover and BMD were measured in 43 consecutive patients with HCV (n = 30) or HBV (n = 13) infection without histological evidence for liver cirrhosis. Mean age was 49 years (range 26-77 years). BMD was measured by dual X-ray absorptiometry in the femoral neck (FN) and the lumbar spine (LS) region. In addition, bone metabolism markers were measured. RESULTS: BMD was lowered in 25 (58%) of the patients with chronic hepatitis B or C (FN; 0.76 (0.53-0.99); LS: 0.96 (0.62-1.23) g/cm2). Eight (32%) osteopenic patients were diagnosed with osteoporosis. bone-specific alkaline phosphatase (P= 0.005) and intact parathyroid hormone (iPTH) (P = 0.001) were significantly elevated in the more advanced stages of fibrosis. Mean T-score value was lower in patients with chronic hepatitis C as compared to patients suffering from chronic hepatitis B; however, the difference was not statistically significant (P= 0.09). CONCLUSION: There was a significantly reduced BMD in non-cirrhotic patients with chronic hepatitis B or C infection. Alterations of bone metabolism already occurred in advanced liver fibrosis without cirrhosis. According to our results, these secondary effects of chronic viral hepatitis should be further investigated.

关键词： bone density Chronic viral hepatitis Non cirrhotic patients

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The Effect of Acupuncture on bone Mineral density in Postmenopausal Women

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Journal of Traditional Chinese Medicine 2002年第1期22卷 9-11页

作者：欧阳钢王玲玲王东岩卓铁军申志祥周永生 The Second Clinical Medical College Affiliated to Nanjing University of Traditional Chinese Medicine Nanjing 210029 jiangsu Provincial Hospital of Senile Diseases

　　According to the TCM theory that the kidney is in charge of the bone, the authors carried out a study on the effect of acupuncture on bone mineral density in 40 postmenopausal women with osteoporosis treated by the method of reinforcing the kidney to strengthen the bone, with satisfactory therapeutic results reported as follows.……

关键词： Acupuncture Therapy bone density Aged Female Humans Middle Aged Osteoporosis, Postmenopausal

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A novel non-invasive method for predicting bone mineral density and fracture risk using demographic and anthropometric measures

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Sports Medicine and Health Science 2023年第4期5卷 308-313页

作者： Justin Aflatooni Steven Martin Adib Edilbi Pranav Gadangi William Singer Robert Loving Shreya Domakonda Nandini Solanki Patrick C.McCulloch Bradley Lambert Orthopedic Biomechanics Research Laboratory Department of Orthopedics and Sports MedicineHouston Methodist HospitalHoustonTXUSA Sydney&J.L.Huffines Institute for Sports Medicine&Human Performance Department of Health and KinesiologyTexas A&M UniversityCollege StationTXUSA

Fractures are costly to treat and can significantly increase *** dual-energy x-ray absorptiometry(DEXA)is used to screen at risk people with low bone mineral density(BMD),not all areas have access to *** sought to create a readily accessible,inexpensive,high-throughput prediction tool for BMD that may identify people at risk of fracture for further *** and demographic data were collected from 492 volunteers(♂275,♀217;[44-20]years;Body Mass Index(BMI)=[27.6-6.0]kg/m^(2))in addition to total body bone mineral content(BMC,kg)and BMD measurements of the spine,pelvis,arms,legs and total ***-linear-regression with step-wise removal was used to develop a two-step prediction model for BMC followed by *** selection was determined by the highest adjusted R2,lowest error of estimate,and lowest level of variance inflation(α=0.05).Height(HTcm),age(years),sex^(m=1,f=0),%body fat(%fat),fat free mass(FFMkg),fat mass(FMkg),leg length(LLcm),shoulder width(SHWDTHcm),trunk length(TRNKLcm),and pelvis width(PWDTHcm)were observed to be significant predictors in the following two-step model(p<0.05).Step1:BMC(kg)=(0.0063×HT)+(-0.0024×AGE)+(0.1712×SEX^(m=1,f=0))+(0.0314×FFM)+(0.001×FM)+(0.0089×SHWDTH)+(-0.0145×TRNKL)+(-0.0278×PWDTH)-0.5073;R^(2)=0.819,***2:Total body BMD(g/cm^(2))=(-0.0028×HT)+(-0.0437×SEX^(m=1,f=0))+(0.0008×%FAT)+(0.2970×BMC)+(-0.0023×LL)+(0.0023×SHWDTH)+(-0.0025×TRNKL)+(-0.0113×PWDTH)+1.379;R^(2)=0.89,*** models were also developed to predict leg,arm,spine,and pelvis BMD(R^(2)=0.796-0.864,p<0.05).The equations developed here represent promising tools for identifying individuals with low BMD at risk of fracture who would benefit from further evaluation,especially in the resource or time restricted setting.

关键词： bone bone density Fracture Fracture risk Assessment Osteoporosis

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DEXA overestimates bone mineral density in adults with knee replacements

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Sports Medicine and Health Science 2020年第4期2卷 211-215页

作者： Katharine D.Harper Terry A.Clyburn Stephen J.Incavo Bradley S.Lambert Department of Orthopedics&Sports Medicine Houston Methodist Hospital6445 Main StreetOutpatient CenterSuite 2500HoustonTXUnited States Department of Orthopedics Washington DC VA Medical Center50 Irving St.NWWashington D.CUnited States

We examined bone mineral density(BMD)measurements made by dual-energy-xray-absorptiometry(DEXA)taken from 100 patients(♂46/♀54,66±6yr)who previously underwent single total-knee arthroplasty(TKA)to determine if automated software-based artifact detection(ASAD)adequately removes implant artifact from the DXA image before analysis and if potential inaccuracies could be overcome through manual artifact correction(MAC).We also sought to determine if software-based inaccuracies would result in fracture risk misclassification(Low-BMD/Osteopenia=Young-Adult T-Score<−1).Select Results:When using ASAD,limbs with implants had higher BMD(+12.0±1.7%,p<0.001)compared to control limbs resulting in a 2.5±0.2%overestimation of total-body BMD(single implant).Consequently,the prevalence of osteopenia in 95%of patients who would have been observed to have low leg BMD(18/19 patients)and 80%of those found to have low total-body BMD(4/5 patients)would have gone *** overestimation was eliminated when using *** results reveal a potential issue with ASAD for total-body DEXA scans in TKA patients and highlight the importance of careful review and MAC in those with joint replacements before making diagnostic decisions.

关键词： Dual-energy-xray-absorptiometry DXA DEXA bone density Total joint replacement Arthroplasty Osteopenia Osteoporosis

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Benefit period using alendronate to increase bone mineral density in women with osteoporosis?

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Chinese Medical Journal 2005年第5期118卷 383-390页

作者： Ferda Ozdemir Meliha Rodoplu Department of Physical Medicine and Rehabilitation Trakya University School of Medicine Edirne TurkeyDepartment of Physical Medicine and Rehabilitation Trakya University School of Medicine Edirne Turkey

Background Alendronate, a nitrogen-containing bisphosphonate is a specific inhibitor of bone resorption and now in the forefront of treatment of osteoporosis. In this study, we reported a significant increase in bone mineral density (BMD) of the spine and the hip in postmenopausal women taking alendronate at 10 mg/d for 1, 2 and 3 years. Methods Participants had received daily, oral, 10 mg dose of alendronate for one to three years and placed into one of three groups according to alendronate treatment duration: 41 women received alendronate for 1 year (group Ⅰ), 46 received alendronate for 2 years (group Ⅱ), and 30 received alendronate for 3 years (group Ⅲ). Measurements of bone density had been made by dual energy X-ray absorbtiometry once each year. Results The differences in L2-L4, L2, L4, femoral neck and trochanter BMD values before and after treatment for first group were significantly different. In second group, significant differences between initial and after treatment were found at the other sites except at the Ward’s triangle. In the third group, only a significant increase in the L2-L4, L2, L3, L4, trochanter BMD values between before treatment and at the end of third year was found. Comparisons between groups were performed with Student’s t test. ANOVA was used to test the age, menopause age, menopause duration and initial BMD values between the three groups. Calculated P values of less than 0.05 were considered statistically significant. Conclusions Alendronate had increased BMD significantly at the spine and hip in postmenopausal women over three years. Increases of BMD in third group were significant during the first and second years. However, continued therapy with alendronate had been required to maintain the gain in BMD over the third year.

关键词： alendronate bone density osteoporosis, postmenopausal

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Artificial intelligence models based on non-contrast chest CT for measuring bone mineral density

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中国医学影像技术 2024年第8期40卷 1231-1235页

作者： DUAN Wei YANG Guoqing LI Yang SHI Feng YANG Lian XIONG Xin CHEN Bei LI Yong FU Quanshui Department of Medical Imaging North Sichuan Medical CollegeNanchong 637000China Department of Radiology Suining Central HospitalSuining 629000China Department of Radiology Suining Hospital of Traditional Chinese MedicineSuining 629000China Shanghai United Imaging Intelligence Co.Ltd. Shanghai 201807China

Objective To observe the value of artificial intelligence(AI)models based on non-contrast chest CT for measuring bone mineral density(BMD).Methods Totally 380 subjects who underwent both non-contrast chest CT and quantitative CT(QCT)BMD examination were retrospectively enrolled and divided into training set(n=304)and test set(n=76)at a ratio of 8∶*** mean BMD of L1—L3 vertebrae were measured based on *** bones of T5—T10 vertebrae were segmented as ROI,radiomics(Rad)features were extracted,and machine learning(ML),Rad and deep learning(DL)models were constructed for classification of osteoporosis(OP)and evaluating BMD,*** operating characteristic curves were drawn,and area under the curves(AUC)were calculated to evaluate the efficacy of each model for classification of ***-Altman analysis and Pearson correlation analysis were performed to explore the consistency and correlation of each model with QCT for measuring *** Among ML and Rad models,ML Bagging-OP and Rad Bagging-OP had the best performances for classification of *** test set,AUC of ML Bagging-OP,Rad Bagging-OP and DL OP for classification of OP was 0.943,0.944 and 0.947,respectively,with no significant difference(all P>0.05).BMD obtained with all the above models had good consistency with those measured with QCT(most of the differences were within the range of Ax-G±1.96 s),which were highly positively correlated(r=0.910—0.974,all P<0.001).Conclusion AI models based on non-contrast chest CT had high efficacy for classification of OP,and good consistency of BMD measurements were found between AI models and QCT.

关键词： osteoporosis bone density tomography,X-ray computed artificial intelligence

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