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bmcyclin b and bmcyclin b3 are required for cell cycle progression in the silkworm, bombyx mori

Science China(Life Sciences) 2013年第4期56卷 360-365页

作者： PAN MinHui HONG KaiLi CHEN XiangYun PAN Chun CHEN XueMei KUANG XiuXiu LU Cheng State Key Laboratory of Silkworm Genome biology Southwest University

Cyclin b is an important regulator of the cell cycle G2 to M phase transition. The silkworm genomic database shows that there are two Cyclin b genes in the silkworm (bombyx mori), bmcyclin b and bmcyclin b3. Using silkworm EST data, the cyclin b3 (EU074796) gene was cloned. Its complete cDNA was 1665 bp with an ORF of 1536 bp derived from seven exons and six introns. The bmcyclin b3 gene encodes 511 amino acids, and the predicted molecular weight is 57.8 kD with an isoelectric point of 9.18. The protein contains one protein damage box and two cyclin boxes. RNA interference-mediated reduction of bmcyclin b and bmcyclin b3 expression induced cell cycle arrest in G2 or M phase in bmN-SWU1 cells, thus inhibiting cell proliferation. These results suggest that bmcyclin b and bmcyclin b3 are necessary for completing the cell cycle in silkworm cells.

关键词： bombyx mori cell cycle bmcyclin b bmcyclin b3 cell proliferation

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bmcyclin b and bmcyclin b3 are required for cell cycle progression of silkworm,bombyx mori

BmCyclin B and BmCyclin B3 are required for cell cycle progr...

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第十届家（柞）蚕遗传育种及良种繁育学术研讨会

作者： PAN MinHui HONG KaiLi CHEN XiangYun PAN Chun CHEN XueMei KUANG XiuXiu LU Cheng State Key Laboratory of Silkworm Genome biology Southwest University

Cyclin b is an important regulator of the G2 to M phase in the cell cycle. The silkworm genomic database showed that there are two Cyclin b genes in the silkworm（bombyx mori）, bmcyclin b and bmcyclin b3. Using silkworm ESTs data, the bmcyclin b3（EU074796） gene was cloned. Its complete cDNA length was 1,665 bp and the ORF was 1,536 bp with six introns and seven exons. The bmcyclin b3 gene encoded 511 amino acids, and the predicted molecular weight was 57.8 kD with an isoelectric point of 9.18. It consisted of one protein damage box and two cyclin boxes. Cell cycle arrest in G2 or M phase in bmN-SWU1 cells could be induced by RNA interference-mediated reduction of bmcyclin b and bmcyclin b3 expression, thus inhibiting the cell proliferation. These results suggest that bmcyclin b and bmcyclin b3 are necessary for completing the cell cycle in silkworm cells.

关键词： bombyx mori cell cycle bmcyclin b bmcyclin b3 cell proliferation

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bmcyclin b and bmcyclin b3 are required for cell cycle progression of silkworm,bombyx mori.

BmCyclin B and BmCyclin B3 are required for cell cycle progr...

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中国遗传学会第九次全国会员代表大会暨学术研讨会

作者：潘敏慧 HONG KaiLi CHEN XiangYun PAN Chun CHEN XueMei KUANG XiuXiu 鲁成 State Key Laboratory of Silkworm Genome biology Southwest University

Cyclin b is an important regulator of the G2 to M phase in the cell *** silkworm genomic database showed that there are two Cyclin b genes in the silkworm(bombyx mori), bmcyclin b and bmcyclin *** silkworm ESTs data,the bmcyclin b3(EU074796) gene was *** complete cDNA length was 1,665 bp and the ORF was 1,536 bp with six introns and seven *** bmcyclin b3 gene encoded 511 amino acids,and the predicted molecular weight was 57.8 kD with an isoelectric point of *** consisted of one protein damage box and two cyclin *** cycle arrest in G2 or M phase in bmN-SWU1 cells could be induced by RNA interference-mediated reduction of bmcyclin b and bmcyclin b3 expression,thus inhibiting the cell *** results suggest that bmcyclin b and bmcyclin b3 are necessary for completing the cell cycle in silkworm cells.

关键词： bombyx mori cell cycle bmcyclin b bmcyclin b3 cell proliferation

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