检索结果-南通市图书馆

Prospect of immunotherapy alone in patients with advanced NSCLC with high btmb:a review and a meta-analysis

Holistic Integrative Oncology 2023年第1期2卷 460-471页

作者： Feiyu Zhao Xiaochen Qiu Qinna Yang Shuyue Gao Fan Yang Niansong Qian Departmentof Oncology Chinese PLA Medical SchoolBeijing 100853China Department of General Surgery The First Medical Center of ChinesePLA General HospitalBeijingChina Department of Oncology Department of Respiratory and Critical Care MedicineThe Eighth Medical Center of ChinesePLA General HospitalNo.17 A Heishanhu RoadHaidian DistrictBeijing 100853China

Lung cancer is the most prevalent cancer in the world,and the main treatment for advanced non-small cell lung cancer is immunotherapy combined with *** recent years,bTMB has received increasing attention as an emerging metric for monitoring the efficacy of tumour immunotherapy in terms of its operability,accessibility and real-time *** envisaged whether immunotherapy alone could be used to reduce the side effects of chemotherapy in patients with high bTMB lung *** thus did a meta-analysis in order to show that immunotherapy alone is feasible in patients with high bTMB *** This study aims to compare the efficacy of PD-1/PD-L1 inhibitors(namely,atezolizumab,pembrolizumab,nivolumab,or tislelizumab)versus chemotherapy in NSCLC *** search for relevant studies was conducted in three major databases(i.e.,PubMed,Embase,and Medline)up until January ***,we identified studies that reported risk ratios(HRs)for reporting progression-free survival(PFS)or overall survival(OS),or objective remission rates(ORs)for immunotherapy alone versus chemotherapy in high bTMB and low bTMB patient *** that NSCLC represents the predominant type of lung cancer,we exclusively focused on this *** analysis encompassed a meta-analysis of the identified literature,incorporating heterogeneity analysis and sensitivity *** quality of the evidence is evaluated using the Grading of Recommendations Assessment,Development and Evaluation(GRADE)approach to ascertain the reliability and robustness of the ***-We conducted a meta-analysis of seven randomised controlled trials including 4,755 patients with advanced non-small cell lung cancer(NSCLC)evaluated the efficacy of PD-1 or PD-L1 monotherapy compared to chemotherapy *** patients were randomized to receive either PD-1/PD-L1 treatment alone or chemotherapy alone as a *** the high bTMB patient group,PD-1/PD-L1 monotherapy resulted in significant improve

关键词： blood tumor mutation burden NSCLC Immunotherapy alone Chemotherapy alone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：