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Prediction of severe preeclampsia in machine learning

Medicine in Novel Technology and Devices 2022年第3期15卷 148-153页

作者： Xinyuan Zhang Yu Chen Stephen Salerno Yi Li Libin Zhou Xiaoxi Zeng Huafeng Li Department of Applied Mechanics College of Architecture and EnvironmentSichuan Province Biomechanical Engineering LaboratorySichuan UniversityChengdu610065SichuanChina Department of Biostatistics University of MichiganAnn ArborMIUSA Medical Big Data Center Sichuan UniversityChengdu610065SichuanChina Department of Computer Science University of WisconsinMadisonWIUSA West China Second University Hospital Sichuan UniversityChengdu610041China Department of Applied Mechanics Sichuan UniversityChengdu610065SichuanChina

This study aimed to find out the blood data characteristics of patients and explore the correlation between severe preeclampsia and blood index *** assistance for the early attention direction of severe preeclampsia diagnosis and treatment.19,653 pregnant women presenting to the West China Second University Hospital,Sichuan University from January 2017 to April *** screening,a total of 248 patients,124 severe preeclampsia cases,and 124 controls were selected for this ***-three blood examination variables were obtained from routine blood work,hepatic,renal and coagulation function *** gradient boosting machine(light GBM),decision tree and random forest were used for date *** randomly divided 35%of the original data as a testing set to conduct internal validation of the performance of the prediction *** area under receiver operating characteristic curve(AUC)was used as the main score to compare the three ***,a binary classification light GBM model based on aspartate aminotransferase,direct bilirubin and activated partial thromboplastin time ratio can predict severe preeclampsia with sensitivity of 88.37%,specificity of 77.27%,AUC of 89.74%and positive predictive value of 65.96%.We believe relevant quantifiable indicators can establish an effective prediction model,which can provide guidance for early detection and prevention of severe preeclampsia.

关键词： Preeclampsia Screening Prediction blood examination Data characteristics

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Long-term Toxicity of Maxing Erchen Zhike Granules

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Medicinal Plant 2020年第5期11卷 27-31页

作者： Jiabao MA Zhenyuan WEI Shuang WU Jiahuan WEI Shengbin CHEN Jinhua LIU Zhengteng YANG The First Affiliated Hospital of Guangxi University of Chinese Medicine Nanning 530023China Guangxi Zhuang Yao Medicine Center of Engineering and Technology Nanning 530200China

[Objectives]To study the long-term toxicity of Maxing Erchen Zhike granules to rats after intragastric administration,so as to provide reference for its preclinical safety evaluation.[Methods]Total 80 rats were randomly and evenly divided into high-dose group(1.2 mL/100 g,120 g/kg),middle-dose group(96.0 g/kg),low-dose group(72.0 g/kg)and blank control *** rats in the treatment groups were administered with corresponding doses of Maxing Erchen Zhike granules,and those in the blank control group were given with equal-amount normal *** administration lasted for 30 consecutive *** the experiment,the rats'feed intake,activity,feces and other conditions and toxicity reactions were observed every *** 24 h of the last administration,12 rats(half male and half female)were randomly selected from each *** of the rats was anesthetized with 10%chloral hydrate solution(0.3 mL/100 g)through intraperitoneal injection and subjected to abdominal aorta blood collection(two tubes)for hematological examination and blood biochemical examination(serum).Then,the main organs of the rats were weighed,and pathological examinations were *** that,the main organs were weighed and pathological examination was *** remaining rats in each group were discontinued and observed for 14 *** the 15th d,they were subjected to the same treatment,and the body weight,organ coefficients,hematological indices,blood biochemical indices and pathological indices were examined.[Results]After 30 d of administration,there was no abnormality in the appearance and behavior of the *** was no significant difference in the daily consumption of feed among the groups,and there was no special case of weight *** the blood biochemical indices,the ALB and ALT levels of each administration group were significantly different from those of the blank control group(Pexamination show that there was one case of interstiti

关键词： Maxing Erchen Zhike granules Long-term toxicity blood examination Pathological section

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