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Implantable blood clot loaded with BMP-2 for regulation of osteoimmunology and enhancement of bone repair

Bioactive Materials 2021年第11期6卷 4014-4026页

作者： Qin Fan Jinyu Bai Huajian Shan Ziying Fei Hao Chen Jialu Xu Qingle Ma Xiaozhong Zhou Chao Wang Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and DevicesSoochow UniversitySuzhouJiangsu215123China Department of Orthopedics The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu215004China Key Laboratory for Organic Electronics&Information Displays(KLOEID) Institute of Advanced Materials(IAM)and School of Materials Science and EngineeringNanjing University of Posts&TelecommunicationsNanjing210000China

The treatment of large-area bone defects still faces many difficulties and challenges.Here,we developed a blood clot delivery platform loaded with BMP-2 protein(BMP-2@BC)for enhanced bone regeneration.blood clot gel platform as natural biomaterials can be engineered from autologous blood.Once implanted into the large bone defect site,it can be used for BMP-2 local delivery,as well as modulating osteoimmunology by recruiting a great number of macrophages and regulating their polarization at different stages.Moreover,due to the deep-red color of blood clot gel,mild localized hyperthermia under laser irradiation further accelerated bone repair and regeneration.We find that the immune niche within the bone defect microenvironment can be modulated in a controllable manner by the blood clots implantation and laser treatment.We further demonstrate that the newly formed bone covered almost 95%of the skull defect area by our strategy in both mice and rat disease models.Due to the great biocompatibility,photothermal potential,and osteoimmunomodulation capacity,such technology shows great promise to be used in further clinical translation.

关键词： blood clot BMP-2 Osteoimmunology Photothermal therapy Bone repair

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blood Flow Through a Catheterized Artery Having a Mild Stenosis at the Wall with a blood clot at the Centre

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Computer Modeling in Engineering & Sciences 2020年第11期125卷 565-577页

作者： Anber Saleem Salman Akhtar Sohail Nadeem Alibek Issakhov Mehdi Ghalambaz Mathematics and Its Applications in Life Sciences Research Group Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Mathematics and Statistics Ton Duc Thang UniversityHo Chi Minh CityVietnam Department of Mathematics Quaid-i-Azam UniversityIslamabad45320Pakistan Al-Farabi Kazakh National University Faculty of Mechanics and Mathematicsav.al-Farabi71AlmatyKazakhstan Institute of Research and Development Duy Tan UniversityDa Nang City550000Vietnam Faculty of Electrical-Electronic Engineering Duy Tan UniversityDa Nang City550000Vietnam

The blood flow through a catheterized artery having a mild stenosis at the wall together with a blood clot at the centre is studied in the current investigation.Stenosis can occur in vessels carrying blood to brain(i.e.,Carotid arteries),Renal arteries that supply blood to kidneys etc.The flow is refined in such vessels by application of catheter.We have used a Newtonian viscous fluid model and also distinct shapes of stenosis,(i.e.,symmetric and non-symmetric shapes)are considered for this study.The entropy generation togetherwith viscous dissipation is also taken into account for a complete description of heat transfer mechanism.Exact solutions are calculated for the problem subject to given“no slip conditions”.The results are discussed graphically.The velocity quickly increases for a non-symmetric stenosis as compared to a symmetric stenosis.When the height of mild stenosis increases and the channel becomes narrow then the velocity increases in the centre but it decreases with the stenosed wall.However,as the height of blood clotσincreases then the velocity of blood flow reduces with the wall having clot but it remains almost same with the stenosed wall.Streamlines are plotted to visualize the flow pattern.The trapping is symmetric for a symmetric stenosis shape but it changes to non-symmetric trapping when we have a non-symmetric shape of stenosis.

关键词： blood flow catheter stenosed artery blood clot entropy

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Impact of blood clot in Oocyte-Corona-Cumulus Complex during in vitro Fertilization and Embryo Transfer

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Journal of Reproduction and Contraception 2012年第1期23卷 57-63页

作者： Yu-ling HUANG Xiao-ling LONG Yong FAN Wen-hong ZHANG Hong-zi DU Assisted Reproductive Center the Third Affiliated Hospital of Guangzhou Medical CollegeKey Laboratory for the Major Obstetric Disease in Guangdong ProvinceGuangzhou 510150China

Objective To study the impact of blood clots in the oocyte-corona-cumulus complexes （OCCC） during in vitro fertilization and embryo transfer （IVF-ET）.Methods The OCCCs were harvested from the patients undergoing long protocol ovarian hyperstimulation. The OCCCs with blood clots removed or not, were randomly grouped into A or B. The OCCCs without blood clots were group C （the control）.Results The patient＇s age, infertility duration, the average GN consumption, the average days of superovulation and an average number of harvested oocytes showed no significant difference in the 3 groups. The fertilization rate and 2PN rate in group A were the highest, which were 85.4% and 71.1%, respectively, followed by group C, which were 77.5% and 64.9%, respectively. The lowest fertilization rate and 2PN rate were in group B, 75.8% and 62.2%, respectively. Those in group A were significantly higher than those in groups B and C （P〈0.01）, while there was no significant difference between group B and group C. The implantation rates and pregnancy rates showed no significant difference in the 3 groups after transplantation, even if group A got the highest rate among the 3 groups. Conclusion Removing the blood clots in OCCC can improve the outcome of IVF-ET without increasing the cost and complexity of the operation.

关键词： in vitro fertilization and embryo transfer （IVF-ET） blood clot fertilization rate pregnancy

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Intravenous-Accelerated Saline Particles to Unblock Partially Clogged blood Vessels Using a Microcontroller

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Journal of Biosciences and Medicines 2022年第11期10卷 35-44页

作者： Stephon Stewart Dineshen Chuckravanen Idea formulation by Mr. Stephon Stewart Los Angeles USA British Association of Cognitive Neuroscience (BACN) Department of Psychology University of Essex Colchester United Kingdom

This research assesses the speed of saline fluid in vein vessels using venipuncture medical kit as well as DC submersive pumps that are being controlled by a microcontroller. The microcontroller is monitored and governed using a software IDE interface installed on a powerful laptop. Saline solution is being pumped through a medical syringe at variable speeds up to a maximum of 18.39 cm/second to the vein. The novel technique in this research is the usage of two pumps called Pump 1 and Pump 2. Pump 1 is used to physically model the flow of “blood” in human vein and the second pump (Pump 2) is used to generate the accelerated saline particles that are used to break the yellow grease that is placed on the inside of the vein’s wall. A tiny brush is briefly dipped into yellow grease, and then it is used to place one layer (one turn) of yellow grease on the inside of the vein’s wall, and then this procedure is repeated to place consecutive layers of yellow grease onto the inside of the wall of the vein vessel using a tiny brush. It was found that accelerated saline particles can in fact destroy fats that are built up inside the veins’ walls.

关键词： blood clot Fat Deposits Fat Removals Veins Microcontroller Saline Particles

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