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Role of long non-coding RNAs in normal and malignant hematopoiesis

Science China(Life Sciences) 2013年第10期56卷 867-875页

作者： WEI PanPan HAN BoWei CHEN YueQin Key Laboratory of Gene Engineering of Ministry of Education State Key Laboratory for BiocontrolSchool of Life ScienceSun Yat-sen University

Long non-coding RNAs(lncRNAs)are defined as a class of nonprotein-coding transcripts greater than 200 nucleotides in length,which have diverse functions in development and diseases including *** advances have revealed that lncRNAs regulate hematopoietic development at almost every stage,including differentiation of the myelocyte,lymphocyte,and *** regulation of the lncRNAs may block aspects of blood development,which can lead to different types of hematopoietic *** findings highlight the role of lncRNAs as potential therapeutic tools in malignant *** this review,we summarize recent progress in the study of functional lncRNAs associated with blood development,as well as dysregulated lncRNAs involved in diverse blood diseases by interacting with crucial susceptibility genes in different *** addition,we discuss genome-wide studies on lncRNAs,which are helpful for genome screening and in-depth functional study of lncRNAs associated with blood development and disease.

关键词： long non-coding RNA (IncRNA) hematopoiesis blood disease susceptibility gene

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Prevalence of Tick Infestations and Tick-Borne diseases in Cattle in Cameroon

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Open Journal of Animal Sciences 2023年第4期13卷 560-573页

作者： Hamidou Hayatou Félix Meutchieye Fatima Ezzahra Amarir Abdelkbir Rhalem Mohammed Bouslikhane Julius Awah-Ndukum Biotechnology and Bio-Informatics Research Unit Faculty of Agronomy and Agricultural Sciences University of Dschang Dschang Cameroon Laboratory of Parasitology Department of Pathology and Veterinary Public Health Hassan II Agronomy and Veterinary Institute (IAV) Rabat Morocco Laboratory of Microbiology Epidemiology and Pathology of Animal Emerging and Re-Emerging Diseases Research Unit Hassan II Agronomy and Veterinary Institute (IAV) Rabat Morocco Animal Physiology and Health Research Unit Department of Animal Science Faculty of Agriculture and Agricultural Sciences University of Dschang Dschang Cameroon

Ticks induce huge production and economic losses in the livestock industry and create serious environmental, animal and human health problems. The study was carried out to characterize tick species and determine the prevalence of tick infestation and tick-borne diseases in cattle in Cameroon. Tick and blood samples were collected from a total of 742 animals and analyzed to determine the type of tick and haemoparasites using standard procedures. Overall, four tick species namely Amblyomma variegatum (75.09%), Rhipicephalus microplus (19.43%), Rhipicephalus decoloratus (0.88%) and Hyalomma marginatum (0.18%) and six blood disease agents including Anapalasma marginale (11.29%), Ehrlichia ruminantium (3.52%), Babesia bovis (1.32%), Babesia major (0.44%), Anaplasma phagocytophilum (0.29%) and Dermatophilus congolensis (3.37%). Various co-infections were recorded and the predominant associations were Amblyomma variegatum-Rhipicephalus microplus (4.06%) and Amblyomma variegatum-Hyalomma marginatum (0.36%);Anaplasma-Ehrlichia (12%), Anaplasma-Dematophylus (8%), Babesia-Anaplasma-Ehrlichia (14%) and Babesia-Anaplasma-Ehrlichia-Dermato-phylus (5%). Breed, sex, age and locality significantly influenced the rate of tick infestation while locality, breed and age significantly influenced the detection of blood disease agents in the study.

关键词： Prevalence Tick blood disease Cattle Cameroon

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Ultrastructural alterations of megakaryocytes in thrombocytopenia:A review of 43 cases

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blood Science 2021年第4期3卷 107-112页

作者： Brian Eyden Yong-Xin Ru Shu-Xu Dong Jing Liu Xiao-Fan Liu Department of Histopathology Christie NHS Foundation TrustManchesterUK State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesInstitute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjinChina

Thrombocytopenia is a frequent occurrence in a variety of hematopoietic diseases;however,the details of the mechanism leading to low platelet count remain *** are a series of progenitor cells responsible for the production of *** in megakaryocytes in the bone marrow are a causative factor resulting in thrombocytopenia in varied *** on ultrastructural analysis of incidentally encountered megakaryocytes in 43 patients with blood diseases marked by low platelet counts,electron micrographs demonstrated that aberrant megakaryocytes predominated in idiopathic thrombocytopenic purpura,aplastic anemia,and myelodysplastic syndrome;autophagy,apoptosis,and cellular damage in megakaryocytes were a prominent feature in aplastic *** the other hand,poorly differentiated megakaryocytes predominated in acute megakaryoblastic leukemia(AMKL)although damaged megakaryocytes were seen in non-AMKL acute *** paper documents the ultrastructural alterations of megakaryocytes associated with thrombocytopenia and reveals distinctive features for particular blood diseases.A comment is made on future avenues of research emphasizing membrane fusion proteins.

关键词： blood disease Megakaryocyte Platelet Thrombocytopenia Ultrastructure

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