检索结果-南通市图书馆

blood circulation activating effect of Sanqi(Radix Notoginseng) on venous thromboembolism rats

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2021年第5期41卷 753-761页

作者： ZHU Chen JIANG Huifang ZHOU Xiaqing ZHANG Zhirong WU Yu FANG Haijun WANG Lingcong Department ICU of the First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310006China Department of Hematology Tongde Hospital of Zhejiang ProvinceHangzhou 310012China Department Orthopaedics of the First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310006China Department Dental of the First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310006China

OBJECTIVE:To explore the blood circulation activating effect and mechanism of Sanqi(Radix Notoginseng)in vivo,using a venous thromboembolism(VTE)rat ***:We established the VTE rat model,and then intervened with low molecular weight hepa-rin(LMWH),as well as low,medium and high doses of Sanqi(Radix Notoginseng),to observe the blood circulation activating effect of Sanqi(Radix Notoginseng)on VTE ***:After the treatment with high concentrations of Sanqi(Radix Notoginseng),the pulmonary thromboembolism was alleviated,and the lower limb thrombosis was markedly ***,the expression quantities of plasma activated partial thromboplastin time,prothrombin time and D-dimer,as well as endothelin,von Willebrand factor,and plasminogen activator inhibitor-1 in thrombosis segment tissues were markedly down-regulated;while those of nitric oxide and tissue-type plasminogen activator were *** low and medium concentration Sanqi(Radix Notoginseng)treatment,no obvious improvement was observed in each ***,the high concentration Sanqi(Radix Notoginseng)showed comparable efficacy to the positive drug ***:This data suggests that high concentration of Sanqi(Radix Notoginseng)is effective in preventing and treating VTE.

关键词： venous thromboembolism blood circulation heparin,low-molecular-weight Sanqi(Radix Notoginseng)

Convenient preparation of charge-adaptive chitosan nanomedicines for extended blood circulation and accelerated endosomal escape

在线全文

学校读者我要写书评

暂无评论

Nano Research 2018年第8期11卷 4278-4292页

作者： Yapei Zhang Yingying Li Jinlong Ma Xinyu Wang Zhi Yuan Wei Wang Key Laboratory of Functional Polymer Materials of the Ministry of Education Institute of Polymer Chemistry College of ChemistryHankai University Tianjin 300071 China Collaborative Innovation Center of Chemical Science and Engineering Nankai University Tianiin 300071 China

A major impediment in the development of chitosan nanoparticles （CTS NPs） as effective drug delivery vesicles is their rapid clearance from blood and endosome entrapment. To overcome these problems, a convenient and promising template system was developed by decorating poly（methacrylic acid）（PMAA） to the surface of 10-hydroxy camptothecin （HCPT）-loaded CTS NPs （HCPT-CTS/ PMAA NPs）. The results show that the presence of negatively charged PMAA significantly elongated the blood circulation time of HCPT-CTS NPs from 12 to 24 h, and reduced the blood clearance （C1） from 30.57 to 6.72 mL/h in vivo. The calculated area under curve （AUC0-24h） and terminal elimination half-life （tl/2） of HCPT-CTS/PMAA NPs were 4.37-fold and 2.48-fold compared with those of HCPT-CTS NPs. Furthermore, the positively charged HCPT-CTS/PMAA NPs triggered by tumor acidic microenvironment （pH 6.5） result in a 453-fold higher cellular uptake than the negatively charged counterparts at pH 7.4. Additionally, HCPT-CTS/PMAA NPs have the ability to escape endosomal entrapment via ＂proton sponge effect＂ after incubation with HepG2 cells for 3 h at pH 6.5. Taken together, these findings open up a convenient, low-cost, but effective way to prepare HCPT-CTS/PMAA NPs as a candidate for developing vectors with enhanced long blood circulation and endosomal escape ability in future clinical experiments.

关键词： chitosanlpoly(methyl methacrylate) blood circulation charge reverse endosomal escape

Hybrid liposome-erythrocyte drug delivery system for tumor therapy with enhanced targeting and blood circulation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2023年第1期10卷 1021-1032页

作者： Kehui Zhu Yingcan Xu Rui Zhong Wanjing Li Hong Wang Yee Shan Wong Subramanian Venkatraman Jiaxin Liu Ye Cao Institute of blood Transfusion Chinese Academy of Medical Sciences&Peking Union Medical CollegeChengduChina Biomedical Engineering School of EngineeringTemasek PolytechnicSingaporeSingapore School of Materials Science and Engineering National University of SingaporeSingaporeSingapore

Liposome,a widely used drug delivery system(DDS),still shows several disadvantages such as dominant clearance by liver and poor target organ *** overcome the drawbacks of liposomes,we developed a novel red blood cell(RBC)-liposome combined DDS to modulate the tumor accumulation and extend the blood circulation life of the existing liposomal ***,RBCs,an ideal natural carrier DDS,were utilized to carry liposomes and avoid them undergo the fast clearance in the *** this study,liposomes could either absorbed onto RBCs’surface or fuse with RBCs’membrane by merely altering the interaction time at 37℃,while the interaction between liposome and RBCs would not affect RBCs’*** the in vivo antitumor therapeutic efficacy study,1,2-dipalmitoyl-sn-glycero-3-phosphocholine(DPPC)liposomes attached onto RBCs’surfaces exhibited lung targeting effect(via RBC-hitchhiking approach)and reduced clearance in the liver,while DPPC liposomes fused with RBCs had prolong blood circulation up to 48 h and no enrichment in any ***,20 mol%of DPPC liposomes were replaced with pH-sensitive phospholipid 1,2-dioleoyl-Sn-glycero-3-phosphoethanolamine(DOPE)as it could respond to the low pH tumor microenvironment and then accumulate in the *** DOPE attached/fusion RBCs showed partial enrichment in lung and about 5-8%tumor accumulation,which were significantly higher than(about 0.7%)the conventional liposomal ***,RBC-liposome composite DDS is able to improve the liposomal tumor accumulation and blood circulation and shows the clinical application promises of using autologous RBCs for antitumor therapy.

关键词： liposomes erythrocyte RBC-hitchhiking blood circulation target delivery

An Experimental Study on Drugs for Improving blood circulation and Removing blood Stasis in Treating Mild Chronic Hepatic Damage

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2001年第3期21卷 225-231页

作者：谢凤瑛李晓良孙克伟褚裕义曹晖谌宁生王伟华刘明德刘伟士毛德文毛树章 The First Affiliated Hospital of Hunan TCM College Changsha 410007

Large and small doses of drugs for improving blood circulation and removing blood stasis were used in model rats to treat mild chronic hepatic damage induced by carbon tetrachloride (CCl4). The results show that large dose of Dang Gui ([symbol: see text] Radix Angelicae Sinensis) and Dan Shen ([symbol: see text] Radix Salviae Miltiorrhizae) (drugs for regulating blood flow) and small dose of Yu Jin ([symbol: see text] Radix Curcumae) and Niu Xi ([symbol: see text] Radix Achyranthis Bidentatae) (drugs for activating blood flow) can significantly elevate the activity of SOD (P

关键词： Alanine Transaminase Animals Aspartate Aminotransferases blood circulation blood Viscosity Carbon Tetrachloride Poisoning Chronic Disease Drugs, Chinese Herbal Hepatitis, Toxic Rats Rats, Wistar Superoxide Dismutase

Changes of blood circulation of the extremity after external fixation for tibia shaft defect: an experimental study

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Traumatology 2001年第2期4卷 89-92页

作者：杨柳李起鸿周仲安 DepartmentofOrthopedics SouthwestHospitalThirdMilitaryMedicalUniversityChongqing400038China

Objective:: To assess and compare two approaches, end to end compression with lengthening (EECL) and segmental bone transport by lengthening (STBL), for long tubular bone defect and nonunion. Methods: Ten goats were used to establish the bone defect model of the mid-tibia. The bone defect ends were shortened step by step with a sulcated half-ring external fixator. Changes of the blood flow of the distal extremity were measured with pulse-Doppler monitor and angiography. Results: The blood flow in the distal extremity was not affected when bone defect was less than 15% of the original length. blood circulatory disorder would appear in the distal extremity when bone defect ranged 15%-20% of the original length. The necrosis would appear in the extremity because of the blood circulatory obstacle when bone defect was more than 20% of the original ***: EECL is an appropriate alternative of treatments if bone defect is less than 15%; while SBTL may be feasible if bone defect is over 20% of the original length. When bone defect ranges between 15% and 20%, EECL should be applied with great care on condition of keeping watch on the extremity circulation with pulse-Doppler monitor.

关键词： blood circulation External fixators Fracture healing Ultrasonography, Doppler, pulsed

Novel technologies and models for studying pharmacological activities of traditional Chinese medicine for promoting blood circulation and removing blood stasis

在线全文

学校读者我要写书评

暂无评论

中国药理学与毒理学杂志 2021年第10期35卷 740-741页

作者： ZHAO Yang WEI Zhong-hong YU Su-yun WANG Ai-yun CHEN Wen-xing ZHENG Xiang-jian Mathew VADAS Jennifer GAMBLE LU Yin Department of Biochemistry and Molecular Biology School of Medicine&Holistic Integrative Medicine Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica School of Pharmacy Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor Nanjing University of Chinese MedicineNanjing 210023China Department of Pharmacology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Centre for the Endothelium Vascular Biology ProgramCentenary InstituteThe University of SydneySydney 2050Australia

OBJECTIVE Our previous studies demonstrated that various ingredients from the traditional Chinese medicine(TCM)for promoting blood circulation and removing blood stasis,as exemplified by cryptotanshinone and salvianolic acid B,exerted striking effects on modulating angiogenesis and vascular permeability,which suggests that they may be effective in treating vascular leak-driven diseases(***,cerebral cavernous malformation and diabetic retinopathy).However,the lack of reliable and advanced technologies and models sets up difficult hurdles for better understanding the role of TCM for promoting blood circulation and removing blood *** this end,this study is to outline numerous cutting-edge platforms that can be utilized for exploring the function of TCM for promoting blood circulation and removing blood stasis in vascular leak-driven *** Two-photon laser scanning fluorescence microscopy was used to observe the interactions between neutrophils and blood vessels in a real-time *** flow system was employed to mimic the in vivo behaviors of ***1-Tag5 spontaneous pancreatic cancer model was used to study the function of tumor blood ***2ECKO(deletion of CCM2 in endothelial cells)mice were employed to establish the cerebral cavernous malformation(CCM)animal ***-computed tomography(micro-CT)was utilized to assess the CCM lesion.Müller cell-knockout mouse model was used to study the progression of diabetic *** permeability in this model was assessed by fluorescein *** The interactions between neutrophils and endothelial cells involve a series of complicated processes,including rolling,adhesion,intraluminal crawling and transmigration,which were all monitored in vivo by two-photon laser scanning fluorescence microscopy in a real-time *** flow system was capable of recapitulating the biological behaviors of neutrophils in *** vascular function in particular vascular

关键词： traditional Chinese medicine blood circulation blood stasis tumor vessels cerebral cavernous malformation diabetic retinopathy

Thirty-six Cases of Hyperglycemia Treated by Promoting blood circulation to Remove Stasis

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2001年第3期21卷 187-188页

作者：宋凤玲毛树章 AIR CHINA Capital International AirportBeijing 100621

Thirty-six cases with hyperglycemia were treated with the method of promoting blood circulation and removing stasis in a course of 4 weeks. The treatment was significantly effective in correcting the abnormal viscosity of the blood by reducing the contents of total plasmic cholesterol (TC), triglyceride (TG) and apoprotein B (apoB), while the level of the apoprotein A (apoA) was elevated.

关键词： blood Viscosity Adult Apolipoproteins A blood circulation Cholesterol Drugs, Chinese Herbal Female Humans Hyperglycemia Male Middle Aged Triglycerides

Dark red tongue color formation caused by hyperglycemia is attributed to decreased blood flow of tongue tissue partially due to nuclear factor-kappa B pathway activation

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2023年第6期43卷 1118-1125页

作者： JIN Shenyi LIU Yahua HAN Xu CAI Mengjie XU Jiatuo LU Hao CHEN Qingguang Department of Endocrinology Diabetes InstituteShuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Basic Medical College Shanghai University of Traditional Chinese MedicineShanghai 201203China

OBJECTIVE:To investigate the potential mechanisms underlying the dark red tongue color formation induced by ***:A high-fat diet and intraperitoneal injection of streptozotocin were used to establish a diabetes *** color and blood flow of tongues were analyzed by the Tongue Diagnosis Analysis System and laser Doppler flowmetry,*** factors and adhesion factors were measured in the circulation and tongue tissue by an enzyme-linked immunosorbent *** blotting was employed to evaluate nuclear factor-kappa B(NF-κB)p50 and inhibitor of kappa B kinase protein expression levels in the ***,the NF-κB inhibitor,pyrrolidine dithiocarbamic acid ammonium salt was utilized to repress NF-κB pathway activation to validate that the NF-κB pathway plays a key role in blood flow and dark red tongue color ***:The diabetic rats displayed a dark red tongue color that was accompanied by NF-κB pathway activation and decreased blood flow in the *** effects could be reversed by the NF-κB ***:Our investigation demonstrated that hyperglycemia led to dark red tongue color formation by decreasing blood flow in the tongue,which was partly due to NF-κB pathway activation.

关键词： tongue diagnosis type 2 diabetes mellitus hyperglycemia NF-kappa B blood circulation

blood Perfusion Effect of Acupuncture on Acute Facial Paralysis Observed by Laser Speckle Technique

在线全文

学校读者我要写书评

暂无评论

Journal of Acupuncture and Tuina Science 2014年第3期12卷 160-164页

作者： Zhong Wei-zheng Cui Han Chen Yi Yang Zhuo-xin Yu Hai-bo Rao Xiao-dan Deng Ying Shenzhen Hospital of Traditional Chinese Medicine Institute of Biomedical and Health Engineering Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen Maternal and Child Health Care Hospital

Objective： To observe effect of acupuncture for acute facial paralysis patients with ocular skin blood perfusion, and to explore the safety and effectiveness of acupuncture in treating acute facial paralysis. Methods： Thirty patients with acute facial paralysis were enrolled and acupunctured in facial points and bilateral Hegu （LI 14）, and the PeriCam laser speckle flow video monitoring system was used not only for recording ocular skin blood perfusion condition in both normal and affected sides before acupuncture, at 15 min after acupuncture and after removing needles immediately, but also for calculating reduction ratio of ocular skin average perfusion in the affected side face compared with the healthy side. Results： Compared with the healthy side of face, the ocular skin blood perfusion of the affected side after acupuncture was significantly different from that before intervention. The blood perfusion levels after 1S-minute acupuncture and at the time of remaining needles were significantly different from the basic line （all P〈0.01）. Conclusion： Acupuncture can significantly improve eve blood perfusion of the acute facial paralysis, enhance metabolic activity of the affected facial tissues, and promote the recovery of facial nerve function.

关键词： Acupuncture Therapy Facial Paralysis Bell Palsy Perfusion blood circulation