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A Dual Ligand Targeted Nanoprobe with High MRI Sensitivity for Diagnosis of Breast Cancer

Chinese Journal of Polymer Science 2014年第3期32卷 321-332页

作者： Fa-ming Gong Zuo-quan Zhang Xiao-dong Chen Lu Zhang Xing-su Yu Qi-hua Yang Xin-tao Shuai 梁碧玲程度 PCFM Lab of Ministry of Education School of Chemistry and Chemical EngineeringSun Yat-sen University Department of Radiology Sun Yat-sen Memorial HospitalSun Yat-sen University Department of Radiology The Fifth Affiliated HospitalSun Yat-sen University Center of Biomedical Engineering Zhongshan School of MedicineSun Yat-Sen University

Antibody targeted delivery is an effective strategy to improve the diagnostic imaging outcome of nanoscale imaging agents in the focal areas. Dual targeting micelles encapsulating superparamagnetic iron oxide were prepared from the amphiphilic block copolymer poly（ethylene glycol）-poly（e-caprolactone）（PEG-b-PCL） with different targeting ligands cRGD and scFv-ErbB single chain antibody conjugated to the distal ends of PEG block. The breast cancer animal model was established by subcutaneous injecting the BT474 cells into the BALB/c-nu female nude mice and then employed to assess the potential of the dual ligand targeted magnetic micelles as a novel MRI contrast agent on a 1.5 T clinical MR/scanner. The T2 signal intensity of the tumor in animals receiving the dual ligand targeted magnetic micelles via tail vein decreased more significantly than the single ligand targeted and nontargeted magnetic micelles. These results indicate that the dual ligand targeted magnetic micelles, cRGD/scFv-ErbB-PEG-PCL-SPION, have great potential to act as a new type of effective nanoscale MRI contrast agent for early diagnosis of breast cancer.

关键词： block copolymer micelle Superparamagnetic iron oxide (SPI0) Breast cancer Magnetic resonance imaging(MRI) Herceptin c(Arg-Gly-Asp-d-Phe-Lys) (cRGDfK).

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Organic Templates for Inorganic Nanocrystal Growth

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Energy & Environmental Materials 2019年第1期2卷 38-54页

作者： Bo Li Ning You Yachao Liang Qi Zhang Wenjie Zhang Meng Chen Xinchang Pang Department of Chemical and Biomolecular Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Henan Joint International Research Laboratory of Living Polymerizations and Functional Nanomaterials Engineering Laboratory of High Performance Nylon Engineering Plastics of CPCIFIndustrial Technology Research InstituteSchool of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China

Nanocrystals provide a variety of size and shape-dependent properties with applications in a wide range of areas, gaining much attention in the past few years. However, due to the nature of the kinetic nanocrystal growth, the procedures often require strict experimental conditions and the shape and size of nanocrystals are difficult to control. In such context, organic templates, which are artificially modified or synthesized, can direct inorganic nanocrystal nucleation and growth to achieve desired shape, size and ultimately properties. In this review article, two general categories of organic templates used for making inorganic nanomaterials are discussed:biotemplates(e.g., peptide, lipid, DNA, and capsid) and block copolymer templates(e.g., block copolymer micelles, star-like block copolymer unimicelles). The goal of this review is to bridge these gaps and help foster a greater awareness of the range and applicability of different organic templating techniques within the field of nanotechnology.

关键词： biotemplate block copolymer micelle mineralization organic template self-assembly

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Enhanced Fluorescence of Organic and Polymeric compounds with Quinoline Ring

Enhanced Fluorescence of Organic and Polymeric compounds wit...

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2010年两岸三地高分子液晶态与超分子有序结构学术研讨会（暨第十一次全国高分子液晶态与超分子有序结构学术论文报告会）

作者： Jin-Long Hong,Chung-Tin Lai Department of Materials and Optoelectrical Science,National Sun Yat-Sen University, Kaohsiung 80424

Effect of aggregation-induced emissions(AIE) of several organic and polymeric materials containing quinoline ring were characterized with the purpose to evaluate its relationship with the extent of restricted intramolecular rotation(RIR).Three methodologies were used to generate RIR,which directly leads to enhanced fluorescence:1) Internally hindering the intamolecular rotation by bulky substituent: Bulky quinoline substituent was used as one of the rotors linked to the central stator in

关键词： Aggregation-induced emission restricted intramolecular rotation quinoline tetraphenylthiophene block copolymer micelle

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