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Research on Effects of Comorbidities Disease on Anticoagulation and bleeding disorders Risk in Patients with Overdosage of Vitamin K Antagonist Anticoagulant

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Open Journal of Emergency Medicine 2023年第3期11卷 68-79页

作者： Si Dung Chu Minh Thi Tran Hai Phong-Vinh Bao International General Hospital Haiphong Vietnam Department of Internal Medicine Vietnam University of Traditional Medicine and Pharmacy Hanoi Vietnam

Objectives: Research on effects of comorbidities disease on anticoagulation overdose in patients receiving anticoagulant therapy with vitamin K antagonists anticoagulant (VKAs) drugs at HaiPhong-VinhBao International General Hospital. Methods: Description and Prospective study. Research on 79 patients receiving anticoagulant therapy with VKAs who have an INR testing index of more than anticoagulation dose with VKAs and check INR every 4 weeks. Results: The average research age is 65.65 ± 12.17 years [33: 85], most of the elderly group. The Male group is lower than the female group (p > 0.05). Patients with hemorrhage signs account for 22.8%. The INR testing index has an average value is 5.88 ± 3.0 [3.02 - 23.95];The group of INR > 5 level is a higher risk of bleeding than the group of INR ≤ 5 levels, there is statistical difference (p Conclusion: All most patients with anticoagulation overdose are in the elderly group. The group with INR > 5 levels has a higher risk of bleeding than the group with INR ≤ 5 levels, it’s the statistical significance (p 1 but p > 0.05);Patients used VKAs drugs on the background of kidney failure or arthritis pathology are the cause of the increased risk of bleeding, it’s statistical significance (p < 0.05).

关键词： Comorbidities Disease INR VKAs bleeding disorders

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Endoglin in liver fibrogenesis: Bridging basic science and clinical practice

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World Journal of Biological Chemistry 2014年第2期5卷 180-203页

作者： Steffen K Meurer Muhammad Alsamman David Scholten Ralf Weiskirchen Institute of Clinical Chemistry and Pathobiochemistry RWTH University Hospital Aachen D-52074 Aachen Germany Department of Internal Medicine Ⅲ RWTH University Hospital Aachen D-52074 Aachen Germany

Endoglin, also known as cluster of differentiation CD105, was originally identified 25 years ago as a novel marker of endothelial cells. Later it was shown that endoglin is also expressed in pro-fibrogenic cells including mesangial cells, cardiac and scleroderma fibroblasts, and hepatic stellate cells. It is an integral membranebound disulfide-linked 180 kDa homodimeric receptor that acts as a transforming growth factor-β(TGF-β) auxiliary co-receptor. In humans, several hundreds of mutations of the endoglin gene are known that give rise to an autosomal dominant bleeding disorder that is characterized by localized angiodysplasia and arteriovenous malformation. This disease is termed hereditary hemorrhagic telangiectasia type Ⅰ and induces various vascular lesions, mainly on the face, lips, hands and gastrointestinal mucosa. Two variants of endoglin(i.e., S- and L-endoglin) are formed by alternative splicing that distinguishes from each other in the length of their cytoplasmic tails. Moreover, a soluble form of endoglin, i.e.,sol-Eng, is shedded by the matrix metalloprotease-14 that cleaves within the extracellular juxtamembrane region. Endoglin interacts with the TGF-β signaling receptors and influences Smad-dependent and-independent effects. Recent work has demonstrated that endoglin is a crucial mediator during liver fibrogenesis that critically controls the activity of the different Smad branches. In the present review, we summarize the present knowledge of endoglin expression and function, its involvement in fibrogenic Smad signaling, current models to investigate endoglin function, and the diagnostic value of endoglin in liver disease.

关键词： Telangiectasia Signalling Transforming growth factor-β Disease bleeding disorders

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bleeding Complications in Antiplatelet Therapy

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血栓与止血学 2012年第2期18卷 51-52页

作者：包承鑫 Institute of Hematology Chinese Academy of Medical Sciences

Antipatelet therapy paly a vital role in preventing atherothrombotic events in patients with coronary artery disease and in those underging revascularization ***,the therapy may occur at the expense of increase risk of *** a stronger antiplatelet treatment in clinical application,the risk of bleeding causedby antiplatelet agents has become a new and

关键词： Microparticle Thrombotic disorders bleeding disorders

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Micropartcles in Diseases

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血栓与止血学 2010年第3期16卷 99-101页

作者：包承鑫 Institute of Hematology Chinese Academy of Medical Sciences

Microparticles(MPs) are small anucleoid phospholipid vesicles shed from platelets,erythrocytes,leukocytes and endothelial *** contains a membrane skeletion and are defined by their size and expression on their surface... 详细信息

关键词： Microparticle Thrombotic disorders bleeding disorders

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Adenotonsillectomy in high risk patients: Hematologic abnormalities and COVID-19 considerations

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2021年第3期7卷 174-178页

作者： Ryan Ruiz Kavita Dedhia Department of Otolaryngology-Head and Neck Surgery University of PennsylvaniaChildren’s Hospital of PhiladelphiaPhiladelphia 19104USA

Adenotonsillectomy is one of the most common surgical procedures performed by *** is vital that surgeons are aware of the risks in performing this surgery especially during the COVID-19 pandemic and in children with hematologic *** this review we describe common hematologic disorders often noted in pediatric patients undergoing this procedure,as well as proper screening and management of these *** addition,we also address the impact of the COVID-19 pandemic and some measures to help mitigate the risks of this procedure during this time.

关键词： Adenotonsillectomy Tonsillectomy Tonsillectomy and adenoidectomy bleeding disorders Sleep apnea Covid-19 Sickle cell disease Pediatrics Recurrent tonsillitis

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