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Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm

Protein & Cell 2023年第4期14卷 262-278页

作者： Kuisheng Liu Xiaocui Xu Dandan Bai Yanhe Li Yalin Zhang Yanping Jia Mingyue Guo Xiaoxiao Han Yingdong Liu Yifan Sheng Xiaochen Kou Yanhong Zhao jiqing Yin Sheng Liu jiayu Chen Hong Wang Yixuan Wang Wenqiang Liu Shaorong Gao Shanghai Key Laboratory of Matemal Fetal Medicine Clinical and Translational Research Center of Shanghai First Matemity and Infant HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Shanghai Institute of Matermal-Fetal Medicine and Gynecologic Oncology Shanghai First Matermity and Infant HospitalTongji UniversityShanghai 200092China

Self-organized blastoids from extended pluripotent stem(EPs)cells possess enormous potential for investigating postimplantation embryo development and related ***,the limited ability of postimplantation development of Eps-blastoids hinders its further *** this study,single-cell transcriptomic analysis indicated that the“trophectoderm(TE)-like structure”of EPSblastoids was primarily composed of primitive endoderm(PrE)-related cells instead of TE-related *** further identified PrE-like cells in EPS cell culture that contribute to the blastoid formation with TE-like *** of PrE cell differentiation by inhibiting MEK signaling or knockout of Gata6 in EPS cells markedly suppressed EPS-blastoid ***,we demonstrated that blastocyst-like structures reconstituted by combining the EPs-derived bilineage embryo-like structure(BLEs)with either tetraploid embryos or tetraploid TE cells could implant normally and develop into live *** summary,our study reveals that TE improvement is critical for constructing a functional embryo using stem cells in vitro.

关键词： EPS cells blastoid primitive endoderm(PrE) trophectoderm(TE) Gata6

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Human embryos in a dish - modeling early embryonic development with pluripotent stem cells

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Cell Regeneration 2022年第1期11卷 40-43页

作者： Xiukun Wang Guang Hu Epigenetics and Stem Cell Biology Laboratory National Institute of Environmental Health Sciences Research Triangle ParkDurhamNC 27709USA

Stem cell-based embryo models present new opportunities to study early embryonic *** a recent study,Kagawa et *** an approach to create human pluripotent stem cell-based blastoids that resemble the human *** blastoids efficiently generated analogs of the EPI,TE,PrE lineages with transcriptomes highly similar to those found in ***,the formation of these lineages followed the same sequence and pace of blas-tocyst development,and was also dependent on the same pathways required for lineage ***,the blastoids were capable of attaching to stimulated endometrial cells to mimic the process of *** more comprehensive analysis is needed to confirm its validity and usefulness,this new blastoid system presents the latest development in the attempt to model early human embryogenesis in vitro.

关键词： Pluripotent stem cells Stem cell-based embryo models blastoid

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