检索结果-南通市图书馆

Current Medical Science 2021年第3期41卷 405-419页

作者： Wei CHENG Tian-tian YU Ai-ping TANG Ken HE YOUNG Li YUI Department of Hematology the Second Affiliate Hospital of Nanchang UniversityNanchang 330006China Division of Hematopathology and Department of Pathology Duke University Medical CenterDurham 27710USA

blastic plasmacytoid dendritic cell neoplasm(BPDCN)is a rare hematological malignancy characterized by recurrent skin nodules,an aggressive clinical course with rapid involvement of hematological organs,and a poor prognosis with poor overall *** is derived from plasmacytoid dendritic cells(pDCs)and its pathogenesis is *** tumor cells show aberrant expression of CD4,CD56,interleukin-3 receptor alpha chain(CD 123),blood dendritic cell antigen 2(BDCA 2/CD303),blood dendritic cell antigen 4(BDCA4)and transcription factor(E protein)E2-2(TCF4).The best treatment drugs are based on experience by adopting those used for either leukemia or *** with drug resistance generally occurs *** cell transplantation after the first complete remission is recommended and tagraxofusp is the first targeted *** this review,we summarize the differentiation of BPDCN from its cell origin,its connection with normal pDCs,clinical characteristics,genetic mutations and advances in treatment of *** review provides insights into the mechanisms of and new therapeutic approaches for BPDCN.

关键词： blastic plasmacytoid dendritic cell neoplasm plasmacytoid dendritic cell genetic mutations immunophenotype therapeutics

blastic plasmacytoid dendritic cell neoplasm with skin and bone marrow involvement: Report of three cases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第33期9卷 10293-10299页

作者： Jiang-Hong Guo Hong-Wei Zhang Li Wang Wei Bai Jin-Fen Wang Department of Pathology Shanxi Cancer HospitalTaiyuan 030000Shanxi ProvinceChina Department of Hematology Shanxi Cancer HospitalTaiyuan 030000Shanxi ProvinceChina

BACKGROUND blastic plasmacytoid dendritic cell neoplasm(BPDCN)is a rare and highly aggressive hematopoietic *** is difficult to diagnose because of the overlap in morphologic and immunophenotypic features with various cutaneous lymphatic hematopoietic *** SUMMARY We report on three BPDCN cases,all characterized by skin nodules and examined by histology,immunohistochemical detection,in situ hybridization for Epstein-Barr virus,and *** also review the relevant *** patients were positive for CD56 and negative for Epstein-Barr encoded small *** patients had bone marrow *** is the main treatment for BPDCN,but case 1 showed bone marrow suppression and case 2 developed recurrence after *** 1 survived for 7 mo,case 2 for 17 mo,and case 3 for 9 *** An accurate pathological diagnosis is a precondition for treatment,and the diagnosis of BPDCN should be based on a combination of clinical symptoms,pathological characteristics,immunophenotype,and other auxiliary *** is necessary to clarify the clinicopathological features and biological behavior of BPDCN to improve its understanding by both clinicians and *** 2 survived significantly longer than the other two cases,suggesting that the treatment received by case 2 was more effective.

关键词： blastic plasmacytoid dendritic cell neoplasm Diagnosis Immunohistochemistry Skin lesion Follow-up Case report

blastic plasmacytoid dendritic cell neoplasm:Two case reports

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2024年第9期15卷 1207-1214页

作者： Yi-Qian Ma Zhan Sun Yu-Mei Li Hui Xu Department of Dermatology The Affiliated Hospital of Jiangsu UniversityZhenjiang 212000Jiangsu ProvinceChina

BACKGROUND blastic plasmacytoid dendritic cell tumor(BPDCN)is a rare and highly invasive lymphohematopoietic tumor that originates from plasmacytoid dendritic *** has an extremely poor *** lesions are usually the first manifestation of BPDCN,although the tumor may also invade the bone marrow,lymph nodes,peripheral blood,and other parts of the body,leading to several other manifestations,requiring further differentiation through skin biopsy and *** SUMMARY In the present paper,the cases of 2 patients diagnosed with BPDCN are *** immunohistochemistry analysis of these 2 patients revealed positivity for CD4,CD56,and ***,no standard chemotherapy regimen is available for ***,intensive therapy for acute lymphoblastic leukemia was applied as the treatment method for these 2 *** Although allogeneic bone marrow transplantation could be further effective in prolonging the median survival the ultimate prognosis was *** treatment modalities tailored for elderly patients will help prolong survival.

关键词： blastic plasmacytoid dendritic cell neoplasm Skin CD4 CD56 CD123 Venetoclax Case report

blastic plasmacytoid dendritic cell neoplasm in Jinhua,China:Two case reports

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第22期12卷 5263-5270页

作者： Jia-Wei Cai Meng-Yao Li Wei-Hao Wang Hong-Qi Shi Yi-Hui Yang Jia-Jun Chen Department of Pathology Jinhua HospitalJinhua 321000Zhejiang ProvinceChina Department of Pathology Shaoxing People’s HospitalShaoxing 312000Zhejiang ProvinceChina Department of Urology Shaoxing People's HospitalShaoxing 312000Zhejiang ProvinceChina

BACKGROUND blastic plasmacytoid dendritic cell neoplasm(BPDCN)is a rare and clinically aggressive hematologic malignancy originating from the precursors of plasmacytoid dendritic *** often involves the skin,lymph nodes,and bone marrow,with rapid clinical progression and a poor *** BPDCN diagnosis is mainly based on the *** SUMMARY In this paper,we retrospectively analyzed 2 cases of *** patients were elderly *** lesions manifested as skin *** manifestations included diffuse and dense tumor cell infiltration of the dermis and subcutaneous *** staining showed that cluster of differentiation CD4,CD56,CD43,and CD123 were *** In this paper,we retrospectively analyzed 2 cases of *** patients were elderly *** lesions manifested as skin *** manifestations included diffuse and dense tumor cell infiltration of the dermis and subcutaneous *** staining showed that cluster of differentiation CD4,CD56,CD43,and CD123 were positive.

关键词： blastic plasmacytoid dendritic cell neoplasm Skin Clinical pathology Immunophenotype Hematopoietic stem cell transplantation Case report

Azacitidine maintenance therapy for blastic plasmacytoid dendritic cell neoplasm allograft: A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第1期12卷 136-141页

作者： Li-Li Tao Hui-Ting Wen Zi-Yi Wang Juan Cheng Li Zhao Department of Hematology The First Clinical Medical CollegeLanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Hematology The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND blastic plasmacytoid dendritic cell neoplasm(BPDCN)is a rare,highly invasive malignant *** is no universally accepted standard of care because of its rarity and the dearth of prospective *** is still challenging for some patients to achieve persistent clinical remission or cure,despite the success of allogeneic hematopoietic stem cell transplantation(allo-HSCT),indicating that there is still a significant recurrence *** report a case of prevention of BPDCN allograft recurrence by azacitidine maintenance therapy and review the relevant *** SUMMARY We report a 41-year-old man with BPDCN who was admitted to hospital due to skin sclerosis for>5 mo’*** was diagnosed by combined clinical assessment and laboratory *** diagnosis,the patients underwent induction consolidation chemotherapy to achieve the first complete remission,followed by bridging ***-transplantation,azacitidine(75 mg/m2 for 7 d)was administered as maintenance therapy,with repeat administration every 4–6 wk and appropriate extension of the chemotherapy *** 10 cycles,the patient has been disease free for 26 mo after *** assessments of bone marrow morphology,minimal residual disease,full donor chimerism,Epstein–Barr virus,and cytomegalovirus all yielded normal results with no abnormalities *** Azacitidine may be a safe and effective maintenance treatment for BPDCN following transplantation because there were no overt adverse events during the course of treatment.

关键词： blastic plasmacytoid dendritic cell neoplasm Azacitidine Allogeneic hematopoietic stem cell transplantation Maintenance therapy Case report

Advancing the understanding and management of blastic plasmacytoid dendritic cell neoplasm:Insights from recent case studies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第31期12卷 6441-6446页

作者： Yan Luo Li-Juan Wang Cheng-Long Wang Department of Stomatology The People's Hospital of Dadukou DistrictChongqing 400084China Department of Pathology The Chongqing Hospital of Traditional Chinese MedicineChongqing 400021China

We specifically discuss the mechanisms of the pathogenesis,diagnosis,and management of blastic plasmacytoid dendritic cell neoplasm(BPDCN),a rare but aggressive haematologic malignancy characterized by frequent skin manifestations and systemic *** article enriches our understanding of BPDCN through detailed case reports showing the clinical,immunophenotypic,and histopathological features that are critical for diagnosing this *** cases highlight the essential role of pathologists in employing advanced immunophenotyping techniques to accurately identify the disease early in its course and guide treatment ***,we explore the implications of these findings for management strategies,emphasizing the use of targeted therapies such as tagraxofusp and the potential of allogeneic haematopoietic stem cell transplantation in achieving *** editorial underscores the importance of interdisciplinary approaches in managing BPDCN,pointing towards a future where precision medicine could significantly improve patient outcomes.

关键词： blastic plasmacytoid dendritic cell neoplasm Immunophenotyping Targeted therapies Haematologic malignancy Pathogenesis