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The therapeutic mechanism of black soybean in atherosclerosis based on network pharmacology

Food Therapy and Health Care 2019年第4期1卷 130-139页

作者： Yi-Xin Jiang Ming-Han Zhao Qing-Feng Wang Biological Engineering Department Liaoning Vocational College of EconomicsShenyang 110122China College of Life Science and Engineering Shenyang University Shenyang 110044China Basic Medical College Liaoning University of Traditional Chinese MedicineShenyang 110032China

Objective:To investigate the cardiovascular mechanism of black soybean,the biological characteristics of black soybean were studied by bioinformatics,and the mechanism of its treatment for atherosclerosis was further ***:Firstly,the basic data sets of effective components and corresponding targets of black beans were constructed,and then mapped to the AS background network obtained from DisGeNET database and CTD ***,the potential targets of black beans acting on AS were *** constructing the protein-protein interaction(PPI)network,the topological characteristics of these targets were *** and GO were enriched to obtain the potential mechanism of black soybean acting on ***:There were 12 bioactive components reported in black *** them,beta-sitosterol,stigmasterol and N-(4-hydroxyphenylethyl)ACTINIDINE were the three most active *** are 19 targets of black soybeans acting on PPI network of AS *** them,ADRB2 and PTGS2 are important targets for black soybeans to alleviate *** therapeutic pathways include arachidonic acid metabolism and serotonin ***:black soybean can play a therapeutic role in AS through multi-target and *** application of network pharmacology can quickly clarify the characteristics of functional foods and identify their potential targets and mechanisms for disease treatment.

关键词： black bean Cardiovascular disease Network pharmacology Mechanism of action

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