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Immunohistochemical Expression of p53 and p63 in Adenomas and Carcinomas of Canine Mammary Glands

Open Journal of Veterinary Medicine 2012年第1期2卷 21-24页

作者： Erika M. Terra Marcela M. M. P. Rodrigues Geórgia M. Magalhaes Mirela T. Costa Renée L. Amorim Noeme S. Rocha Pathology Veterinary Department Sao Paulo State University Sao Paulo Brazil Veterinary Clinics and Surgery Department Sao Paulo State University Sao Paulo Brazil Veterinary Clinics Department Sao Paulo State University Sao Paulo Brazil

Mammary tumors are very common in female dogs and its prognosis varies significantly according to the tumor invasion degree. Myoepithelial layer destruction is considered a differential diagnosis parameter of in situ from invasive lesions in human breast cancer. Aiming to evaluate the immunohistochemical expression of p63, a protein specifically expressed by myoepithelial cells of mammary gland, and its correlation with p53 expression, 10 adenomas and 20 carcinomas with and without metastasis of canine mammary gland were studied. There was no significant difference between adenomas and carcinomas for both proteins staining, however, the percentage and continuity of staining was lower in metastatic carcinomas. There was no correlation between p53 and p63 expression, but the higher values of p53 staining were found in carcinomas, according to previous studies. Results showed that p63 is specifically expressed also in myoepithelial cells of canine mammary gland. However, in order to ensure its use as a prognostic marker in canine mammary tumors, further studies involving a higher number of samples should be conducted.

关键词： bitches Mammary Tumor Prognostic Marker

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Reproductive Parameters and Characteristics of Labrador Breed

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Journal of Pharmacy and Pharmacology 2018年第10期6卷 920-923页

作者： Carlos Sorribas Mónica Pirles Laura Schiaffino Carlos Pagni Clinic of pets. National University of Rosario. Ov Lagos and Route 33. 2170 Casilda. Argentinian Republic English. National University of Rosario. Ov Lagos and Route 33. 2170 Casilda. Argentinian Republic

For a period of two years, a survey of 110 parturitions of Labrador breed bitches was carried out in Rosario City to determine the average number of puppies per litter, percentage of dystocia of all parturitions, percentage of males and females born and causes of dystocia, as well as the incidence of clinically detectable congenital pathologies. Over a total of 110 parturitions ninety three （84.5%） parturitions were normal and 17 （15.5%） were dystocic ones, it was established that atony 1 was the most numerous cause of dystocia （53%）, followed by atony 2 （23%）, dystocia by fetal disorders （6%）, hydramnios （6%）, uterine rupture （6%） and vagina fibrous band （6%）. The whole puppies born was 866, 7.9 puppies per litter, if comparison between normal parturitions and dystocic ones is made, numbers are 7.05 and 8.02 respectively. When sex evaluation percentage is made 51.5% are males and 48.5% are females. When viability of puppies born is calculated it is established that in ones born by normal parturition perinatal death was 9.3%, while in those born by dystocia it was 10.9%. Among clinically verifiable congenital disorders low weight at birth was the most frequent congenital alteration, followed by cleft palate, lethal congenital edema or walrus syndrome and hare lip.

关键词： Labrador retriever parturition bitches dystocia congenital hydramnios.

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