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RNA-sequencing-based Gene Expression Profile Revealing Breast Tumor Development Induced by Exposure of bisphenol s

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Chemical Research in Chinese Universities 2023年第3期39卷 441-448页

作者： ZHOU Peng XIAO Yu ZHOU Xin LIU Jianjun ZHAO Chao Bionic sensing and Intelligence Center Institute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055P.R.China Department of Ultrasound The First Affiliated Hospital of Shenzhen University Health Science CenterShenzhen Second People’s HospitalShenzhen518035P.R.China Department of Breast and Thyroid surgery Shenzhen Second People’s Hospital/The First Hospital Affiliated to Shenzhen UniversityShenzhen518035P.R.China shenzhen Key Laboratory of Modern Toxicology Shenzhen Medical Key Discipline of Health Toxicology(2020—2024)Shenzhen Center for Disease Control and PreventionShenzhen518055P.R.China University of Chinese Academy of sciences Beijing100049P.R.China shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055P.R.China Key Laboratory of Molecular Epidemiology of Hunan Province School of MedicineHunan Normal UniversityChangsha410013P.R.China

Aberrant biological information occurs naturally at exposure to bisphenol A or its alternatives,which was associated with the occurrence and development of breast ***,the potential molecular variation in gene expression during the breast tumor development is still ***,high throughput RNA sequencing(RNA-seq)and bioinformatics analysis were used to investigate the variation of tumor-mRNA profile exposed with BPs5(5µg/kg bw/day)or BPs50(50µg/kg bw/day)in tumor development-associated MMTV-PyMT transgenic mouse ***,we analyzed the dose-effects of bisphenol s(BPs)and BPs-induced tumor development on the gene level *** dose-effect aspects of BPs,the increased concentration of BPs significantly changed the numbers and enrichment pathway of differentially expressed genes(DEGs),especially the enrichment pathways involved in up-regulated genes including ribosome,peroxisome proliferators-activated receptor(PPAR)signaling pathway and progesterone-mediated oocyte maturation *** effects of BPs exposure to tumor development,expression of IgκC,Zfp385b,Cldn10,Pgr and snord14d has changed significantly throughout the tumor *** ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)results obtained from BPs-induced tumor development showed that the functional classifications were intensively altered with an extension of time in high-dose BPs *** acquired DEGs and pathway information could help with the accurate exploration of molecular mechanisms of tumor development,screening of molecular targets of breast cancer,and toxicological evaluation of environmental pollutants.

关键词： bisphenol s RNA-sequencing Breast cancer Tumor development

Identification of glycerophospholipid fatty acid remodeling by using mass spectrometry imaging in bisphenol s induced mouse liver

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Chinese Chemical Letters 2018年第8期29卷 1281-1283页

作者： Chao Zhao Peisi Xie Ti Yang Hailin Wang Arthur Chi Kong Chung Zongwei Cai state Key Laboratory of Environmental and Biological Analysis Department of Chemistry Hong Kong Baptist University state Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

bisphenol A（BPA） plays an important role in metabolic disorders. As a major alternative to BPA, it is unclear whether the exposure of bisphenol s（BPs） may result in lipidome disturbance. Using a mouse model, we investigated the effects of BPs exposure on metabolism and spatial distribution of lipids by using lipidomics analysis and matrix-assisted laser desorption/ionization（MALDI）-mass spectrometry imaging（MsI） in mouse liver tissues. Lipid metabolites displayed significant up-regulation in phosphatidylethanolamines（PE）, lysophosphatidylcholines（LPC）, lysophosphatidylethanolamines（LPE） and lysophosphatidylserine（LPs） as well as remarkable down-regulation in phosphatidylcholine（PC） and phosphatidylserine（Ps） in mouse liver after the exposure at 100 m g BPs/kg body weight/*** obtained results indicated that the lipidome of liver was perturbed significantly in glycerophospholipid（GP） fatty acid remodeling pathway upon the BPs exposure. We applied MsI and multivariate statistical analysis to evaluate the abundance variation of lipid markers in BPs-treated liver sections and to compare with the analytical results from olive oil-treated liver sections. Differential structural lipids with up-regulated PE（20：1/20：4）, LPC（20：4）, LPE（20：4）, LPs（33：4） and down-regulated PC（20：4/22：6）and Ps（18：0/22：6）, which were related to GP fatty acid remodeling, changed and co-localized in the liver sections. To explore the cause of variation of lipid abundance, expression of enzymes that regulate biosynthesis and metabolism of fatty acid in liver tissues were analyzed. Consistent with the results of liver lipidome and spatial distribution, a decrease in hepatic expression of LPC acyltransferase 1（LPCAT1）,LPCAT2 and LPs acyltransferase and an increase expression of LPCAT3, LPCAT4, LPE acyltransferase 1（LPEAT1）, LPEAT2 and phospholipase A2 s were observed in GP fatty acid remodeling pathway. Our results demonstrated that exposure to BPs could induce the GP fatty acid remodeling, which m

关键词： Lipidomics MALDI-MsI bisphenol s bisphenol A Mouse liver

Associations of prenatal exposure to bisphenols with BMI growth trajectories in offspring within the first two years:evidence from a birth cohort study in China

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World Journal of Pediatrics 2024年第7期20卷 701-711页

作者： Chao Xiong Kai Chen Lu-Li Xu Yi-Ming Zhang Hua Liu Meng-Lan Guo Zhi-Guo Xia Yu-Ji Wang Xiao-Feng Mu Xiao-Xuan Fan Jing-Quan Chen Yu-Ru Liu Yuan-Yuan Li Wei Xia You-Jie Wang Ai-Fen Zhou Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital) Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430016China Key Laboratory of Environment and Health Ministry of Education and Ministry of Environmental Protectionand State Key Laboratory of Environmental HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Maternal and Child Health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Background Prenatal bisphenol exposure has been reported to be associated with lower birth weight and obesity-related indicators in early *** findings warrant an investigation of the relationship between prenatal bisphenol exposure and the dynamic growth of *** study aimed to evaluate the relationship of maternal bisphenol concentration in urine with the body mass index(BMI)growth trajectory of children aged up to two years and to identify the critical exposure *** A total of 826 mother–offspring pairs were recruited from Wuhan Children’s Hospital between November 2013 and March *** urine samples collected during the first,second,and third trimesters were analyzed for bisphenol A(BPA),bisphenol s,and bisphenol F(BPF)*** of length and weight were taken at 0,1,3,6,8,12,18,and 24 ***'s BMI was standardized using the World Health Organization reference,and group-based trajectory modeling was used to identify BMI growth *** associations between prenatal bisphenol exposure and BMI growth trajectory patterns were assessed using multinomial logistic regression *** The BMI growth trajectories of the 826 children were categorized into four patterns:low-stable(n=134,16.2%),low-increasing(n=142,17.2%),moderate-stable(n=350,42.4%),and moderate-increasing(n=200,24.2%).After adjusting for potential confounders,we observed that prenatal exposure to BPA during the second trimester[odds ratio(OR)=2.20,95%confidence interval(CI)=1.09–4.43]and BPF during the third trimester(OR=3.28,95%CI=1.55–6.95)at the highest quartile concentration were associated with an increased likelihood of the low-increasing BMI ***,in the subgroup analysis by infant sex,the positive association between the highest quartile of prenatal average urinary BPF concentration during the whole pregnancy and the low-increasing BMI trajectory was found only in girls(OR=2.82,95%CI=1.04–7.68).Conclus

关键词： Birth cohort study bisphenol A bisphenol s bisphenol F Body mass index trajectory Prenatal exposure

New environmental factors related to diabetes risk in humans:Emerging bisphenols used in synthesis of plastics

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World Journal of Diabetes 2023年第8期14卷 1301-1313页

作者： Rafael Moreno-Gómez-Toledano María Delgado-Marín Alberto Cook-Calvete Claudia González-Cucharero Nunzio Alcharani Beatriz Jiménez-Guirado Ignacio Hernandez Rafael Ramirez-Carracedo Laura Tesoro Laura Botana sandra sánchez-Esteban Javier Diez-Mata Jose Luis Zamorano Ricardo J.Bosch Carlos Zaragoza Marta saura Universidad de Alcalá Department of Biological Systems/PhysiologyAlcaláde Henares 28871Spain Cardiology Department University Hospital Ramón y CajalMadrid 28034Spain Laboratory of Cardiovascular Pathophysiology Joint Translational Research UnitUniversity Francisco de Vitoria School of MedicineMadrid 28034Spain Instituto Ramón y Cajal de Investigación sanitaria-IRYCIs Madrid 28034Spain

BACKGROUND Diabetes mellitus(DM)is one of the largest global health emergencies of the 21st *** recent years,its connection with environmental pollutants,such as bisphenol A(BPA),has been demonstrated;consequently,new structurally similar molecules are used to replace BPA in the plastics industry(BPs,BPF and BPAF).AIM To carry out a systematic review to allow coherent evaluation of the state of the ***,a meta-analysis was performed to unify the existing quantitative *** Firstly,a systematic review was carried out,using the terms“(bisphenol)AND(Diabetes OR Hyperglycemia)”,to maximize the number of ***,three authors analyzed the set of ***,a meta-analysis was performed for each BP,using RevMan *** addition,funnel plots were developed to study publication *** The systematic analysis of the literature revealed 13 recent articles(2017–2023)related to the study *** qualitative analysis showed interesting data linking diabetes to the three most widely used substitute BPs in the industry:BPs,BPF and ***,the meta-analysis determined a positive relationship with BPs,BPF and BPAF,which was only statistically significant with *** There is a need to apply the precautionary principle,regulating the use of new ***,replacing BPA with BPs,BPF or BPAF is unlikely to protect the population from potential health risks,such as DM.

关键词： bisphenol s bisphenol F bisphenol AF Diabetes mellitus systematic review Meta-analysis

Association between urinary concentrations of bisphenol A substitutes and diabetes in adults

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World Journal of Diabetes 2022年第7期13卷 521-531页

作者： Rafael Moreno-Gómez-Toledano Esperanza Vélez-Vélez María I Arenas Marta saura Ricardo J Bosch Universidad de Alcalá Department of Biological Systems/Physiology UnitAlcaláde Henares 28871Spain Fundación Jiménez Díaz school of Nursing Jiménez Díaz FoundationAutonomous University of MadridMadrid 28040Spain Universidad de Alcalá Department of Biomedicine and BiotechnologyAlcaláde Henares 28871Spain Centro de Investigación en Red de Enfermedades Cardiovasculares Instituto Ramón y Cajal de Investigación SanitariaMadrid 28034Spain

BACKGROUND Due to new restrictions on the use of bisphenol A(BPA),industries are beginning to replace it with derived molecules such as bisphenol s and F(BPs and BPF).There is extensive evidence in the academic literature on the potential health effects of BPA,which is known to be a diabetogenic ***,there are few publications related to new compounds derived from *** To perform an epidemiological study of urinary BPs and BPF in the American National Health and Nutrition Examination survey(NHANEs)cohort,and analyze their possible relationship with diabetes *** NHANEs datasets from 2013 to 2016 were used due to the urinary BPF and BPs *** from 3658 adults were analyzed to perform regression analysis exploring the possible relationship between BPA-derived compounds and *** Descriptive statistics,linear regression modeling,and logistic regression analysis revealed a significant relationship between urinary BPs,but not BPF,and diabetes ***,a relationship was observed between both compounds and hypertension and a slight relationship between BPF and *** In the present study,a strong relationship between urinary BPs,not BPF,and diabetes risk has been *** substitute molecules do not exempt the population from potential health risks.

关键词： bisphenol s bisphenol F Diabetes mellitus National Health and Nutrition Examination survey Urine

Emerging bisphenol a replacements(colour developers)in indoor dust from spain

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Emerging Contaminants 2019年第1期5卷 168-172页

作者： María Jesús Duenas-Mas Ana Ballesteros-Gomez soledad Rubio Department of Analytical Chemistry Institute of Fine Chemistry and NanochemistryMarie Curie Building AnnexCampus of RabanalesUniversity of Cordoba14071CordobaSpain

bisphenol A(BPA)and replacements,such as bisphenol s(BPs)and F(BPF)and other substitutes(BPsMAE,D-8 and TGsA)have been recently reported in thermal *** this study,BPA,BPs,BPF;BPs-MAE,D-8 and TGsA were analysed in indoor dust collected in spain from different microenvironments(living rooms,bedrooms,cars and offices).Levels were compared with those reported in our previous study(shops and other public microenvironments,where frequent use of thermal paper is expected).We investigated the differences between microenvironments,possible correlations between compounds and estimated the ingestion ***-MAE,D-8 and TGsA were present at levels up to 529,128 and 356 ng g^-1,respectively,in all the *** highest levels were measured in cars.

关键词： bisphenol A bisphenol F bisphenol s BPs-MAE D-8 TGsA Indoor dust