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bisphenol a in combination with TNF-a selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity

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Cellular & Molecular Immunology 2010年第3期7卷 227-234页

作者： Hongchuan Guo Tianyi Liu Yasushi Uemura Shunchang Jiao Deqing Wang Zilin Lin Yayoi Narita Motoharu Suzuki Narumi Hirosawa Yasuko Ichihara Osamu Ishihara Hirosato Kikuchi Yasushi Sakamoto Satoru Senju Qiuhang Zhang Feng Ling Department of Neurosurgery XuanWu HospitalCapital University of Medical ScienceBeijingChina Department of Oncology Chinese PLA General HospitalBeijingChina Department of Stem Cell Biology and Regenerative Medicine Graduate School of Medical ScienceKansai Medical UniversityOsakaJapan Department of Blood Transfusion Chinese PLA General HospitalBeijingChina Department of Obstetrics and Gynecology Faculty of MedicineSaitama Medical UniversityMoroyamaJapan Department of Biomedical Research Center Division of Analytical ScienceFaculty of MedicineSaitama Medical UniversityMoroyamaJapan Department of Anesthesiology Faculty of MedicineSaitama Medical UniversityMoroyamaJapan Department of Immunogenetics Graduate School of Medical SciencesKumamoto UniversityKumamotoJapan

bisphenol a(BPA)is a monomer used in manufacturing a wide range of chemical products,including epoxy resins and ***,an important endocrine disrupting chemical that exerts estrogen-like activities,is detectable at nanomolar levels in human serum *** pregnancy associated doses of 17b-estradiol(E2)plus tumor-necrosis factor-a(TNF-a)induce distorted maturation of human dendritic cells(DCs)that result in an increased capacity to induce T helper(Th)2 *** current study demonstrated that the presence of BPA during DC maturation influences the function of human DCs,thereby polarizing the subsequent Th *** the presence of TNF-a,BPA treatment enhanced the expression of CC chemokine ligand 1(CCL1)in *** addition,DCs exposed to BPA/TNF-a produced higher levels of IL-10 relative to those of IL-12p70 on CD40 ligation,and preferentially induced Th2 *** exerts the same effect with E2 at the same dose(0.01–0.1 mM)with regard to DC-mediated Th2 *** findings imply that DCs exposed to BPA will provide one of the initial signals driving the development and perpetuation of Th2-dominated immune response in allergic reactions.

关键词： bisphenol a dendritic cells Th1/2 human

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bisphenol a induces testicular oxidative stress in mice leading to ferroptosis

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Asian Journal of Andrology 2023年第3期25卷 375-381页

作者： Li Li Min-Yan Wang Hua-Bo Jiang Chun-Rong Guo Xian-Dan Zhu Xia-Qin Yao Wei-Wei Zeng Yuan Zhao Ling-Kan Chi Reproductive Medicine Center Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Pathology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Key Laboratory of Maternal Fetal Medicine Department of Fetal Medicine and Prenatal Diagnosis CenterShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghai 201203China Teaching Experimental Center Shanghai University of Traditional Chinese MedicineShanghai 201203China Laboratory Animal Center Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Obstetrics Shanghai First Maternity and Infant HospitalTongji University School of MedicineShanghai 201203China Department of Gynecology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China

bisphenol a is a common environmental factor and endocrine disruptor that exerts a negative impact on male reproductive *** exploring bisphenol a-induced testicular cell death using the Institute of Cancer Research(ICR)mouse model,we found that a ferroptosis phenomenon may *** were divided into six groups and administered different doses of bisphenol a via intragastric gavage once daily for 45 consecutive *** was then collected to determine the levels of superoxide dismutase and *** sperm was also collected for semen analysis,and testicular tissue was collected for ferritin content determination,electron microscope observation of mitochondrial morphology,immunohistochemistry,real-time quantitative polymerase chain reaction,and western blot *** to bisphenol a was found to decrease sperm quality and cause oxidative damage,iron accumulation,and mitochondrial damage in the testes of *** addition,bisphenol a was confirmed to affect the expression of the ferroptosis-related genes,glutathione peroxidase 4(GPX4),ferritin heavy chain 1(FTH1),cyclooxygenase 2(COX2),and acyl-CoA synthetase 4(ACSL4)in mouse testicular ***,we speculate that bisphenol a induces oxidative stress,which leads to the ferroptosis of testicular ***,the inhibition of ferroptosis may be a potential strategy to reduce male reproductive toxicity caused by bisphenol a.

关键词： bisphenol a ferroptosis mitochondrial damage oxidative stress testicular toxicity

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Photocatalytic degradation of bisphenol a using an integrated system of a new gas-liquid-solid circulating fluidized bed reactor and micrometer Gd-doped TiO_2 particles

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Journal of Environmental Sciences 2012年第7期24卷 1317-1326页

作者： Zhiliang Cheng Xuejun Quan Jinxin Xiang Yuming Huang Yunlan Xu Key Laboratory of Eco-environments in Three Gorges Reservoir Region(Ministry of Education of China) College of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400175China College of Chemistry and Chemical Engineering Chongqing University of TechnologyChongqing 400050China

A new gas-liquid-solid circulating fluidized bed photocatalytic reactor （GLSCFBPR） with internally placed multi-layered UV lamps was developed. Micrometer Gd-TiO2 particles and commercial nanometer P25-TiO2 were chosen as the photocatalysts, and the hazardous substance bisphenol a （BPA） was chosen as the model pollutant to investigate the performance of this new photocatalytic system. The results showed that the photocatalytic degradation efficiency of the micrometer Gd-TiO2 particles was similar to that of the nanometer P-25 particles at their respective optimum dosage but the former could be easily separated out by gravity. After investigating the effects of process parameters on the photocatalytic BPA degradation, the response surface method （RSM） was further used for process optimization. The interactions among process parameters, i.e., TiO2 concentration, superficial gas velocity and superficial liquid velocity were discovered and a related analysis was carried out to explore the underlying mechanism. A quadratic mathematic model was established and performed satisfactorily when used for prediction. The optimum conditions for this new process were as follows： TiO2 concentration 4.5 g/L, superficial gas velocity 7.83 x 10-3 m/sec and superficial liquid velocity 8.65 x 10-3 m/sec.

关键词： fluidized bed photocatalytic reactor Gd-doped titanium dioxide photocatalytic degradation bisphenol a

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HYDROGEN-BONDING INDUCED CHANGE OF CRYSTALLIZATION BEHAVIOR OF POLY(BUTYLENE SUCCINATE) IN ITS MIXTURES WITH bisphenol a

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Chinese Journal of Polymer Science 2013年第12期31卷 1685-1696页

作者：罗发亮 Fa-hai Luo Qian Xing Xiu-qin Zhang Hong-qiao Jiao Min Yao Chun-tao Luo 王笃金 Key Laboratory of Energy Resource and Chemical Engineering of Ningxia Ningxia University Liupanshan High School of Ningxia Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Engineering PlasticsInstitute of ChemistryChinese Academy of Sciences Shenhua Ningxia Coal Industry Group

In the present work, the blend of poly（butylene succinate）（PBS） and bisphenol a （BPA） was prepared by solution mixing, and the intermolecular interactions between the two components were characterized by a combination of nuclear magnetic resonance （NMR） and Fourier transform infrared spectroscopy （FTIR）. The results showed that intermolecular hydrogen-bonding forms between the carbonyl group of PBS and phenol hydroxyl of BPA. With the increase of BPA content, more hydrogen bonds were formed. The effect of hydrogen bonding on the crystallization behavior of PBS was investigated by differential scanning calorimetry （DSC） and polarized optical microscopy （POM）. The results showed that the overall isothermal crystallization kinetics and the spherulite growth rate of PBS decrease with the increase of BPA content, while the PBS spherulite size increases with BPA content.

关键词： Poly(butylene succinate) bisphenol a Hydrogen bonding Crystallization behavior.

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Immunotoxicity of bisphenol a to Carassius auratus lymphocytes and macrophages following in vitro exposure

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Journal of Environmental Sciences 2007年第2期19卷 232-237页

作者： YIN Da-qiang HU Shuang-qing GU Ying WEI Li LIU Shu-shen ZHANG Ai-qian State Key Laboratory of Pollution Control and Resource Reuse School of the Environment Nanfing University Nanjing 210093 China Key laboratory of Yangtze River Water Environment Ministry of Education Tongji University Shanghai 200092 China

bisphenol a （BPA） is the monomer component of polycarbonate plastics and classified as an endocrine disrupting chemical （EDC）. The reproductive toxicity of BPA has been extensively studied in mammals; however, relatively little information is available on the immunotoxic responses of fish to BPA. In this study, we investigated the effects of BPA on the immune functions of lymphocytes and macrophages in Carassius auratus. The effects of BPA were compared with those of two natural steroid hormones, estradiol and hydrocortisone. Proliferation of the two types of cells in response to PHA was measured using colorimetric MTT assay. Macrophage respiratory burst stimulated by Con A was measured using chemiluminescence assay. Results showed that BPA （0.054-5.4 mg/L）, estradiol （0.0002-2.0 mg/L） and hydrocortisone （5-50 mg/L） significantly induced Carassius auratus lymphocyte proliferation while higher doses of hydrocortisone （500-5000 mg/L） appeared to be inhibitory. BPA （0.005-50 mg/L）, estradiol （0.005-800 mg/L） and hydrocortisone （0.005-500 mg/L） markedly enhanced macrophage proliferation, whereas higher doses of BPA （500-1000 mg/L） appeared to inhibit cell proliferation. Furthermore, higher dosage of BPA （50 mg/L） and hydrocortisone （50 and 500 mg/L） suppressed the macrophages respiratory burst while estradiol is stimulative all the doses tested （0.05-500 mg/L）. In conclusion, BPA could have immunotoxicity to Carassius auratus and functional changes of lymphocyte and macrophage in Carassius auratus may be different between low and high dosages.

关键词： bisphenol a immunotoxicology lymphocyte macrophage Carassius auratus

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Impact factors of the degradation of bisphenol a by nitrocellulose membrane under illumination

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Journal of Environmental Sciences 2021年第2期33卷 193-202页

作者： Li Wu Xinmiao Jin Tongqian Zhao Haipo Wang Zhifeng Dai Institute of Resources and Environment Henan Polytechnic UniversityJiaozuo 454000China Collaborative Innouation Center for Coal-Bed Methane and Shale Gas of Henan Jiaozuo 454000China

Nitrocellulose membrane(NCM)can produce hydroxyl radicals under illumination,which promotes the oxidative degradation of organic *** this paper,NCM was used to oxidize bisphenol a(BPA)under simulated *** effects of p H,temperature,light intensity,anion and cation on the degradation of BPA were *** photodegradation process of BPA was *** optimal photolysis rate was 0.031 min^(-)1 when the temperature was 30°C,the light intensity was 2.67×10^4 Lux,and the p H value was *** alkaline environment,temperature and light intensity can promote the photodegradation of *** for nitrate ions,anions and cations can inhibit the photodegradation of *** with cations,anions have a greater inhibitory effect on BPA *** degradation products of BPA by NCM were analyzed by gas chromatographic/*** study may provide useful information for the BPA degradation by NCM in complex water samples.

关键词： Nitrocellulose membrane bisphenol a Degradation Illumination Impact factors

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Fabrication of CuFe_(2)O_(4)/Bi_(12)O_(17)Cl_(2) photocatalyst with intrinsic p-n junction for highly efficient bisphenol a degradation

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Journal of Environmental Sciences 2024年第2期136卷 547-558页

作者： Yong Wang Cheng Liu Haoyun Hu Qiujun Lu Haiyan Wang Chenxi Zhao Fuyou Du Ningli Tang Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials College of Chemistry and BioengineeringGuilin University of TechnologyGuilin 541004China College of Biological and Environmental Engineering Changsha UniversityChangsha 410022China

The construction and application of novel highly efficient photocatalysts have been the focus in the field of environmental pollutant *** this work,a novel CuFe_(2)O_(4)/Bi_(12)O_(17)Cl_(2)photocatalysts were synthesized by simple hydrothermal and chemical precipitation *** fabricated CuFe_(2)O_(4)/Bi_(12)O_(17)Cl_(2)composite exhibited much higher photocatalytic activity than pristine CuFe_(2)O_(4)and Bi_(12)O_(17)Cl_(2)in the removal of bisphenol a(BPA)under visible-light illumination,which ascribed to the intrinsic p-n junction of CuFe_(2)O_(4)and Bi_(12)O_(17)Cl_(2).The photocatalytic degradation rate of BPA on CuFe_(2)O_(4)/Bi_(12)O_(17)Cl_(2)with an optimized CuFe_(2)O_(4)content(1.0 wt.%)reached 93.0%within 30 *** capture experiments of active species confirmed that the hydroxyl radicals(·OH)and superoxide radicals(·O_(2)^(-))played crucial roles in photocatalytic BPA degradation ***,the possible degradation mechanism and pathways of BPA was proposed according to the detected intermediates in photocatalytic reaction process.

关键词： Bi_(12)O_(17)Cl_(2) CuFe_(2)O_(4) Heterojunction bisphenol a Photocatalytic degradation

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Functional graphene oxide nanosheets modified with cyclodextrins for removal of bisphenol a from water

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Chinese Journal of Chemical Engineering 2021年第11期34卷 79-87页

作者： Zhi-Hao Chen Zhuang Liu Lei Zhang Quan-Wei Cai Jia-Qi Hu Wei Wang Xiao-Jie Ju Rui Xie Liang-Yin Chu School of Chemical Engineering Sichuan UniversityChengdu 610065China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China

A novel type of functional graphene oxide nanosheets(GNs)modified with b-cyclodextrins(b-CDs)have been developed by coating dopamine-functionalized cyclodextrin(DACD)molecules on GNs for removing bisphenol a(BPA)molecules from *** DACD molecules with both b-CD groups for achieving adsorption property and dopamine(DA)groups for achieving adhesion property are synthesized by grafting DA onto carboxymethyl-b-cyclodextrin(CmbCD).The proposed DACD molecules can be firmly coated on the surfaces of various inorganic and organic *** to the large specific surface area of GNs,DACD-coated GNs(DACD@GNs)are proposed for efficient adsorption separation of BPA molecules from *** to the host-gust complexation between the BPA molecules in water and b-CDs on DACD@GNs,the fabricated DACD@GNs exhibit excellent adsorption *** adsorption kinetics can be explained via the pseudo-second-order model *** experimental adsorption capacity of DACD@GNs is 11.29 mg·g^(-1) for ***,after the adsorption process,the DACD@GNs can be easily separated from aqueous solutions via vacuum filtration with porous membranes,and then regenerated by simply washing with *** proposed strategy in this study can be used for effectively functionalizing the surfaces of various substrates with functional b-CDs,which is highly promising in applications in the field of adsorption separations,especially water treatments.

关键词： Adsorption separation b-Cyclodextrin bisphenol a Graphene oxide nanosheets Dopamine

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Hierarchically porous polymers with ultra-high affinity for bisphenol a enables high efficient water purification

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Science China Chemistry 2021年第8期64卷 1389-1400页

作者： Zelun Li Juan Wang Qian Chen Kelong Ai Lehui Lu State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China Department of Pharmacology Xiangya School of Pharmaceutical SciencesCentral South UniversityChangsha410078China

The widespread use of bisphenol a(BPA)poses a serious threat to the environment and human ***,efficient removal of BPA in water is incredibly challenging,owing to the inert chemical nature and electrical neutrality of *** order to solve this problem,for the first time,we propose that a strategy of designing conjugated porous polymers with the pore size matching the size of BPA can greatly enhance the binding force of *** this basis,we developed a novel conjugated poly 1,3,5-tri[4-(diphenylamino)phenyl]benzene(MPDPB)with intrinsic pore matching the size of BPA and multi-stage porous structure by editing polymerization with *** binding energy of MPDPB to BPA is the highest at present(37.84 kcal/mol),which is 2.3 times that of the most powerful adsorbent previously reported and five times that of the conventional *** advantages make MPDPB have super-high adsorption performance towards BPA and high absorbing stability under extreme ***,MPDPB could be easily loaded on a non-woven fabric to generate point-of-use devices,which could eliminate more than 99.8%of BPA,making it the best BPA candidate adsorbent *** believe that the proposed material design derived from the specific structure of the contaminant molecule can be extended to exploring further innovative adsorbents.

关键词： bisphenol a porous polymer water purification adsorbent micropollutant

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QSAR of Estrogen of bisphenol a with 3D Vector of Atomic Property Correlation

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Chinese Journal of Structural Chemistry 2007年第8期26卷 988-994页

作者： CHEN Zhi-Tao ZHOU Peng HE Liu LI Zhi-Liang College of Chemistry and Chemical Engineering Chongqing University Chongqing 400044 China College of Biomedical Engineering Chongqing University Chongqing 400044 China

Considering atomic property vector and atomic correlative function, the 3-dimensional structural vector of atomic property correlation （3D-VAPC）, a novel descriptor,is defined to characterize a 3-dimensional molecular structure by introducing self-adaptability regulation mechanism and the idea of orientating to customers. Characterizing the structures of 25 bisphenol a compounds by this vector, the QSAR models of three kinds of estrogen activities （ER affinities, gene induction and cell proliferation） have high multiple correlation coefficient （Rcum^2=0.933, 0.813, 0.959） and cross verification coefficient （Qcum^2=0.847, 0.953, 0.798） by support vector machine （SVM）, which suits for nonlinear circumstances. The above results show that the models successfully express the correlation between structure and three kinds of estrogen activities. Therefore, 3D-VAPC exactly reflects the molecular structural information and SVM method correctly describes the correlation between information and property of the compounds.

关键词： 3D vector of atomic property correlation (3D-VAPC) support vector machine (SVM) quantitative structure-activity relationship (QSAR) bisphenol a estrogen

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