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Biomedical and Environmental Sciences 2020年第1期33卷 58-61页

作者： Iva Simic Gordana Jovanovic Snjezana Herceg Romanic Darija Klincic Marijana Matek Saric Aleksandar Popovic Institute for Medical Research and Occupational Health Ksaverska cesta 2PO Box 29110001 ZagrebCroatia Institute of Physics Belgrade National Institute of the Republic of SerbiaUniversity of BelgradePregrevica 11811080 BelgradeSerbia Department of Health Studies University of ZadarSplitska 123000 ZadarCroatia Faculty of Chemistry University of BelgradeStudentski trg 12-1611000 BelgradeSerbia

One of the most commonly used non-invasive methods for assessing human exposure to pollution is the analysis of human milk.Human milk analyses help estimate the exposure of infants[1].This is why breast milk is receives scientific interest,and various methods for determining different pollutants from the environment are being developed[2,3].

关键词： Optimization Gas Chromatography-electron Ionization-tandem Mass Spectrometry Determining Toxic Non-ortho Polychlorinated biphenyls Breast Milk

The associations between the environmental exposure to polychlorinated biphenyls (PCBs) and breast cancer risk and progression

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Science China Chemistry 2010年第5期53卷 974-979页

作者： LIU SiJin ,ZHANG ShuPing,QU Chen,LIU Wei & DU YuGuo State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing China

Polychlorinated biphenyls(PCBs) are chlorinated biphenyl compounds with wide applications in the industry.In spite of a ban on their production in the late 1970s,PCBs,as a group of POPs,are still persistent and widely spread in the environment,posing potential threats to human health.The role of PCBs as etiologic agents for breast cancer has been intensively explored in a variety of in vivo,animal and epidemiologic studies.Initial investigations indicated higher levels of PCBs in mammary tissues or sera corresponded to the occurrence of breast cancer,but later studies showed no positive association between PCB exposure and breast cancer development.More recent data suggested that the CYP1A1 m2 polymorphisms might add increased risk to the etiology of breast cancer in women with environmental exposure to PCBs.PCBs are implicated in advancing breast cancer progression,and our unpublished data reveals that PCBs activate the ROCK signaling to enhance breast cancer metastasis.Therefore,the correlation between PCB exposure and breast cancer risk warrants further careful investigations.

关键词： Polychlorinated biphenyls (PCBs) environmental exposure CYP1A1 polymorphisms breast cancer risk tumor progression

Structure elucidation of polychlorinated biphenyls by X-ray analysis

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Chinese Science Bulletin 1997年第21期42卷 1803-1806页

作者： Miao, XS Chu, SG Xu, XB Jin, XL Chinese Acad Sci Ecoenvironm Sci Res Ctr Beijing 100085 Peoples R China

POLYCHLORINATED biphenyls (PCBs) are a class of compounds of which some members are po-tential threats to the environment. A great deal of research has been carried out on various as-pects of PCBs, including the prediction of their gas chromatographic retention times, the pre-diction of their physical and chemical properties, the study of their toxic equivalency factor ap-proach and the elucidation of their active receptor models, the study of their environmental be-havior and treatment, and so on, all of them are related to their molecular structures.

关键词： polychlorinated biphenyls X-ray analysis molecular structure.

Development of Different Strategies for the Clean-Up of Polychlorinated biphenyls (PCBs) Congeners Using Pressurized Liquid Extraction

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Journal of Environmental Protection 2013年第1期4卷 99-107页

作者： Amal Al-Rashdan Murad I. H. Helaleh Kuwait Institute for Scientific Research Deputy Director General Office for Research Safat Kuwait

The extracted fish samples (w/w) using pressurized liquid extraction (PLE) were cleaned up by applying different adsorbent materials such as: combination of acidic/ basic silica and alumina, florisil, and silica gel either alone or in combination with another sort of sorbent. Different solvents such as hexane (H), dichloromethane (DCM), with different compositions were used to elute the PCBs target compounds from the spiked fish samples. Overall the mean percentage recoveries for all PCBs congeners using PLE were ranging from 78.6% to 98.7%;from 79.4% to 91.8%;from 65.8% to 104.5% and from 82.4% to 100.9% for cases A, B, C, D and E, respectively. However, the overall mean percentage recoveries for the 13C-PCBs surrogate including: 101, 138, 153, 180 and 209 were ranging from 88.2% to 97.6%;from 79.4% to 90.2%, from 88.3% to 96.4%, from 79.8% to 90.4% and from 83.9% to 95.9%, for cases A, B, C, D and E, respectively. The limits of detection of the proposed method were varied from 0.01 to 0.28 ng/g (w/w) for different PCBs congeners. The proposed method has linear dynamic range from 21.5 ng/g to 109 ng/g. This method was applied to fish samples for the determination of the target PCBs components.

关键词： Polychlorinated biphenyls (PCBs) Pressurized Liquid Extraction (PLE) Adsorbent Materials Gel Permeation Chromatography (GPC) Negative Chemical Ionization (NCI) Marine Sample

Polychlorinated biphenyls Contamination of Sludge in India

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American Journal of Analytical Chemistry 2015年第11期6卷 867-877页

作者： Khageshwar Singh Patel Shobhana Ramteke Bharat Lal Sahu Yogita Nayak Saroj Sharma Chin-Chang Hung School of Studies in Chemistry/Environmental Science Pt. Ravishankar Shukla University Raipur India Department of Chemistry Devi Rathi Mahila Mahavidhaya Rajnandagaon India Institute of Marine Environmental Chemistry and Ecology National Taiwan Ocean University Taiwan

Polychlorinated biphenyls (PCBs) exist in all compartments of the ecosystem due to wide industrial applications and production during burning processes. The PCBs congeners were quantified in the industrial, municipal and agricultural wastes of the most industrialized area of the country, Raipur city, India. The concentration of ΣPCBs in the sludge, sewage and agriculture wastes (n = 4) was ranged from 497 - 800 μg/kg with mean value of 634 ± 146 μg/kg. The PCBs congeners detected in the waste materials were ranged from 56 - 85 with mean value of 75 ± 13. The highest number of congeners was quantified in the sludge materials due to the existence of the heavy PCBs. The PCBs congeners were found to decrease vertically due to the adsorption by the geo-media. The distribution, sources and toxicities of PCBs congeners in the waste materials are discussed.

关键词： Polychlorinated biphenyls Sewage Sludge Contamination

Ligand-mediated contaminant degradation by bare and carboxymethyl cellulose-coated bimetallic palladium-zero valent iron nanoparticles in high salinity environments

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Journal of Environmental Sciences 2019年第3期31卷 303-311页

作者： Xiaoming Ma Di He Adele M.Jones T.David Waite Taicheng An Institute of Environmental Health and Pollution Control Guangdong University of Technology Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control School of Environmental Science and Engineering Guangzhou University of Technology School of Civil and Environmental Engineering University of New South Wales

The application of nanoscale zero-valent iron(nZVI) for the degradation of contaminants has been extensively investigated, however, few studies have focused on degradation in high salinity environments. In this study, the ability of bare and carboxymethyl cellulose(CMC)-coated bimetallic Pd-nZVI particles to degrade 33′44′-tetrachlorobiphenyl in high saline water(SW) is examined with particular attention given to the effects of ethylenediaminetetraacetic acid(EDTA) on the rate of degradation. EDTA enhances the reactivity of Pd-nZVI in SW, with evidence provided to link this to the removal of the passivating layer. Additionally, a conceptual model is proposed which provides a quantitative description of the removal of these iron oxide layers in the presence of EDTA. An optimum EDTA to bare Pd-nZVI molar ratio of 0.1 exists, with insufficient EDTA unable to remove the passivating layer whilst excess EDTA results in Fe loss and enhanced agglomeration due to magnetic attraction of the bare Fe(0) particles. In contrast, CMCcoating of Pd-nZVI assemblages actually impedes degradation, despite the coated particles displaying a smaller average size compared to uncoated particles, with even the presence of EDTA in this case not significantly improving degradation. The reduced reactivity in the presence of CMC is primarily attributed to the effect of CMC on the association of Pd with nZVI particles. In particular, the presence of CMC reduced the total amount of Pd incorporated with the stabilized particles compared to the non-stabilized particles.Additionally, the presence of CMC results in less Pd present in its reactive zero-valent oxidation state.

关键词： Bimetallic zero valent iron ligand-mediated depassivation polychlorinated biphenyls high salinity water

Hexagonally arranged arrays of urchin-like Ag hemispheres decorated with Ag nanoparticles for surface-enhanced Raman scattering substrates

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Nano Research 2015年第7期8卷 2261-2270页

作者： Haibin Tang Guowen Meng Zhongbo Li Chuhong Zhu Zhulin Huang Zhaoming Wang Fadi Li Key Laboratory of Materials Physics and Anhui Key Laboratory of Nanomaterials and Nanotechnology Institute of Solid State Physics Chinese Academy of Sciences P. O. Box 1129 Hefei 230031 China University of Science and Technology of China Hefei 230026 China

The surface topography of noble metal particles is a significant factor in tailoring surface-enhanced Raman scattering （SERS） properties. Here, we present a simple fabrication route to hexagonally arranged arrays of surface-roughened urchin- like Ag hemispheres （Ag-HSs） decorated with Ag nanoparticles （Ag-NPs） for highly active and reproducible SERS substrates. The urchin-like Ag-HS arrays are achieved by sputtering Ag onto the top surface of a highly ordered porous anodic aluminum oxide （AAO） template to form ordered arrays of smooth Ag-HSs and then by electrodepositing Ag-NPs onto the surface of each Ag-HS. Owing to the ordered arrangement of the Ag-HSs and the improved surface roughness, the urchin-like hierarchical Ag-HS arrays can provide sufficient and uniform ＂hot spots＂ for reproducible and highly active SERS effects. Using the urchin-like Ag-HS arrays as SERS substrates, 10-7 M dibutyl phthalate （a member of plasticizers family） and 1.5 × 10-5 M PCB-77 （one congener of polychlorinated biphenyl, a notorious class of pollutants） are identified, showing promising potential for these substrates in the rapid recognition of organic pollutants.

关键词： Ag-hemisphere urchin-like surface roughness polychlorinated biphenyls (pcbs) surface-enhanced Raman scatteringsurface-enhanced Raman sers

Exposure to persistent organic pollutants as potential risk factors for developing diabetes

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Science China Chemistry 2010年第5期53卷 980-994页

作者： WANG ChunXiang,XU ShunQing,LV ZiQuan,LI YuanYuan,WANG YouJie & CHEN Tian Key Laboratory of Environment and Health,Ministry of Education School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China Key Laboratory of Environment and Health Ministry of Education School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan China

Persistent organic pollutants(POPs),such as dioxins,polychlorinated biphenyls(PCBs) ,and organochlorine pesticides(OCPs),which are synthetic chemicals or by-products with an intrinsic resistance to natural degradation processes,are released into the environment,resulting in the widespread dispersal and accumulation in the environment,as well as in human and ecological food chains.Due to their ubiquity in the environment and lipophilic properties,there is emerging concern over the potential risks of human exposure to POPs.Extensive growing evidence indicated that exposure to POPs might be strongly associated with increased risk of a worldwide epidemic of diabetes,especially type 2 diabetes,suggesting that POPs might play a key role in their pathogenesis.Based on summary of the related studies,this paper reviews the epidemiologic and experimental data that addresses the association between increased risk of diabetes and POP exposure,including dioxins,PCBs,OCPs,polybrominated flame retardants(PBFRs),and some environmental estrogens.The potential mechanisms whereby POPs cause diabetes were discussed,such as alterations in lipid metabolism,in glucose transport,in insulin signaling pathway,in steroid metabolism,and disruption of endocrine system,induction of tumor necrosis factor-α(TNF-α) .However,with respect to diabetes,some of the evidence on POPs linked to risk of diabetes was suggestive of a direct or indirect association but was limited or inconclusive.Future research is urgently needed for determining the relative contribution of POPs to diabetes and elucidating the exact mechanisms.

关键词： persistent organic pollutants diabetes dioxins polychlorinated biphenyls organochlorine pesticides

QSAR study on the non-monotonic dose-response curve of PCBs in chicken embryo hepatocyte bioassay

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Science China Chemistry 2009年第5期52卷 662-669页

作者： YunSong Mu AiQian Zhang ChangAn Gao SuFen Peng LianSheng Wang State Key Laboratory of Pollution Control and Resource Reuse School of Environment Nanjing University Nanjing 210093 China

Endocrine disrupting chemicals (EDCs) in the natural environment exhibit a unique non-monotonic dose-response curve and it is impossible to select one simple index to characterize the bilogogical activity of these compounds. Quantitative structure-activity relationship (QSAR) study on non-monotonic dose-response curve has become a real challenge presently. In order to explore the possible mechanism for the non-monotonic dose-response curve of polychlorinated biphenyls congeners (PCBs) in chicken embryo hepatocyte bioassay, AM1 method of ChemOffice was adopted to calculate necessary structure descriptors for PCBs, while the interactions between PCBs and simulated AhR ligand binding domain (LBD) were analyzed by using FlexX in SYBYL7.0. Different binding modes for PCBs have been distinguished not only from aligned conformation but also from free binding energy. Some QSAR models were established separately for both low and high doses ranges, revealing that receptor binding may predominate in the interference of the physiological function of cytochrome P4501A-P4501A in the low doses range. But with the higher doses range, the EROD suppression might be related to acute toxicity owing to molecular polarity or distribution of charges and consequently damage structure and function of chicken embryo hepatocyte.

关键词： polychlorinated biphenyls congeners (PCBs) non-monotonic dose-response curve quantitative structure-activity relationship (QSAR)

Synthesis of P,N-2,2'-biphenyl derivatives with central chirality

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Science China Chemistry 2010年第9期53卷 1907-1913页

作者： JEAN Ludovic POULIQUEN Michael BLANCHET Jérme LASNE Marie-Claire ROUDEN Jacques Laboratoire de Chimie Moléculaire et Thioorganique UMR 6507 CNRS-ENSICAEN & Université de Caen-Basse Normandie6 Boulevard du Maréchal Juin14050 CaenInstitut Normand de Chimie MoléculaireMédicinale et Macromoléculaire(INC3M)

Enantiopure 2-(dicyclohexylphosphino)-1,1'-biphenyl derivatives substituted in the 2'-position by a chiral amino group were prepared.For the compound bearing an acyclic chiral chain,the key step was a Suzuki coupling between bromobenzeneboronic acid and N-Boc-iodoaniline whereas an aromatic nucleophilic substitution allowed the introduction of a chiral pyrrolidine in the 2'-position of the biphenyl backbone.The efficiency of the P,N-biphenyl pyrrolidine derivatives as ligands in Pd-catalyzed arylaminations compares well with that of DavePhos ligand.

关键词： 3-aminopyrrolidines Suzuki coupling biphenyls chiral ligand arylamination