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Polymyxin sensitivity/resistance cosmopolitan status,epidemiology and prevalence among O1/O139 and non-O1/non-O139 Vibrio cholerae:A meta-analysis

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Infectious Medicine 2023年第4期2卷 283-293页

作者： Bright E.Igere Hope Onohuean Declan C.Iwu Etinosa O.Igbinosa Department of Biological Sciences Microbiology UnitDennis Osadebay UniversityAsaba 320242Nigeria Biotechnology and Emerging Environmental Infections Pathogens Research Group(BEEIPREG) Department of Biological SciencesMicrobiology UnitDennis Osadebay UniversityAsaba 320242Nigeria Biopharmaceutics unit Department of Pharmacology and ToxicologySchool of PharmacyKampala International University Ishaka-Bushenyi CampusIshaka-Bushenyi 10101Uganda Department of Microbiology University of PretoriaPretoria 0002South Africa Department of Microbiology Faculty of Life SciencesUniversity of BeninBenin 300213Nigeria

Resistance/sensitivity to polymyxin-B(PB)antibiotic has been employed as one among other epidemiologically relevant biotyping-scheme for Vibrio cholerae into Classical/El Tor ***,recent studies have re-vealed some pitfalls bordering on PB-sensitivity/resistance(PBR/S)necessitating *** study assesses the PBR/S cosmopolitan prevalence,epidemiology/distribution among O1/O139 and nonO1/nonO139 *** *** databases(Web of Science,Scopus and PubMed)were searched to retrieve data from environ-mental and clinical samples employing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA).Random-effect-model(REM)and common-effect-model(CEM)of meta-analysis was performed to de-termine prevalence of PBR/S *** strains,describe the cosmopolitan epidemiological potentials and biotype *** was determined by meta-regression and subgroup *** pooled analyzed iso-lates from articles(7290),with sensitive and resistance are 2219(30.44%)and 5028(69.56%).Among these PB-sensitive strains,more than 1944(26.67%)were O1 strains,132(1.81%)were nonO1 strains while mis-reported Classical biotype were 2080(28.53)respectively indicating potential spread of variant/dual biotype.A significant PB-resistance was observed in the models(CEM=0.66,95%CI[0.65;0.68],p-value=0.001;REM=0.83[0.74;0.90],p=0.001)as both models had a high level of heterogeneity(I^(2)=98.0%;^(2)_(df=33)=1755.09,Qp=2.4932).Egger test(z=5.4017,p<0.0001)reveal publication bias by funnel plot *** subgroup analysis for continents(Asia,Africa)and sources(acute diarrhea)revealed(98%CI(0.73;0.93);55%CI(0.20;0.86)),and 92%CI(0.67;0.98).The Epidemiological prevalence for El tor/variant/dual biotype showed 88%CI(0.78;0.94)with O1 strains at 88%CI(0.78;0.94).Such global prevalence,distribution/spread of phenotypes/genotypes ne-cessitates updating the decades-long biotype classification *** antibiotic stewardship in the post antibiot

关键词： biotyping scheme Environmental nonO1/nonO139 V.cholerae Clinical O1/O139 V.cholerae PB-sensitive/PB-resistant strains Global epidemiological relevance Polymyxin B

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