检索结果-南通市图书馆

Biomaterial-assisted biotherapy:A brief review of biomaterials used in drug delivery,vaccine development,gene therapy,and stem cell therapy

引用

Bioactive Materials 2022年第11期7卷 29-48页

作者： Xuejiao Han Aqu Alu Hongmei Liu Yi Shi Xiawei Wei Lulu Cai Yuquan Wei Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of BiotherapyNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduChina Personalized Drug Therapy Key Laboratory of Sichuan Province Department of PharmacySichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu610072China Sichuan Provincial Key Laboratory for Human Disease Gene Study and Department of Laboratory Medicine Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu610072China

biotherapy has recently become a hotspot research topic with encouraging prospects in various fields due to a wide range of treatments applications,as demonstrated in preclinical and clinical studies.However,the broad applications of biotherapy have been limited by critical challenges,including the lack of safe and efficient de-livery systems and serious side effects.Due to the unique potentials of biomaterials,such as good biocompati-bility and bioactive properties,biomaterial-assisted biotherapy has been demonstrated to be an attractive strategy.The biomaterial-based delivery systems possess sufficient packaging capacity and versatile functions,enabling a sustained and localized release of drugs at the target sites.Furthermore,the biomaterials can provide a niche with specific extracellular conditions for the proliferation,differentiation,attachment,and migration of stem cells,leading to tissue regeneration.In this review,the state-of-the-art studies on the applications of bio-materials in biotherapy,including drug delivery,vaccine development,gene therapy,and stem cell therapy,have been summarized.The challenges and an outlook of biomaterial-assisted biotherapies have also been discussed.

关键词： Biomaterial biotherapy Drug delivery system Vaccine development Gene therapy Stem cell therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent advances of biomaterials in biotherapy

引用

Regenerative Biomaterials 2016年第2期3卷 99-105页

作者： Ling Li Zhi-Yao He Xia-Wei Wei Yu-Quan Wei Laboratory of Aging Research and Nanotoxicology State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengduSichuan610041People’s Republic of China

biotherapy mainly refers to the intervention and the treatment of major diseases with biotechnologies or bio-drugs,which include gene therapy,immunotherapy(vaccines and antibodies),bone marrow transplantation and stem-cell therapy.In recent years,numerous biomaterials have emerged and were utilized in the field of biotherapy due to their biocompatibility and biodegradability.Generally,biomaterials can be classified into natural or synthetic polymers according to their source,both of which have attracted much attention.Notably,biomaterials-based non-viral gene delivery vectors in gene therapy are undergoing rapid development with the emergence of surface-modified or functionalized materials.In immunotherapy,biomaterials appear to be attractive means for enhancing the delivery efficacy and the potency of vaccines.Additionally,hydrogels and scaffolds are ideal candidates in stem-cell therapy and tissue engineering.In this review,we present an introduction of biomaterials used in above biotherapy,including gene therapy,immunotherapy,stem-cell therapy and tissue engineering.We also highlighted the biomaterials which have already entered the clinical evaluation.

关键词： biomaterials biotherapy gene delivery immunotherapy tissue engineering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent advances in systemic lupus erythematosus and microbiota: from bench to bedside

引用

Frontiers of Medicine 2022年第5期16卷 686-700页

作者： Yijing Zhan Qianmei Liu Bo Zhang Xin Huang Qianjin Lu Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases Chinese Academy of Medical SciencesJiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIsInstitute of DermatologyChinese Academy of Medical Sciences and Peking Union Medical CollegeNanjing 210042China Department of Dermatology The Second Xiangya Hospital of Central South UniversityInstitute of Dermatology and Venereology of Central South UniversityHunan Clinical Medicine Research Center for Major Skin Diseases and Skin HealthChangsha 410011China

Systemic lupus erythematosus(SLE)is a complicated autoimmune disease affecting multiple systems and organs.It is highly heterogeneous,and it preferentially affects women at childbearing age,causing worldwide social burden.The pathogenesis of SLE mostly involves genetic predisposition,epigenetic dysregulation,overactivation of the immune system,and environment factors.Human microbiome,which is mostly composed of microbiota colonized in the gut,skin,and oral cavity,provides a natural microbiome barrier against environmental risks.The past decade of research has demonstrated a strong association between microbiota and metabolic diseases or gastrointestinal diseases.However,the role of microbiota in autoimmunity remains largely unknown until recently,when the technological and methodological progress facilitates further microbiota research in SLE.In this review,the latest research about the role and mechanisms of microbiota in SLE and the advances in the development of diagnostic and therapeutic strategies based on microbiota for SLE were summarized.

关键词： systemic lupus erythematosus microbiota biotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Magnetic resonance imaging may predict deep remission in patients with perianal fistulizing Crohn's disease

引用

World Journal of Gastroenterology 2017年第23期23卷 4285-4292页

作者： Lucie Thomassin Laura Armengol-Debeir Cloé Charpentier Valerie Bridoux Edith Koning Guillaume Savoye Céline Savoye-Collet Department of Gastroenterology Rouen University HospitalUniversity of Rouen Department of Radiology Rouen University HospitalUniversity of Rouen Department of Digestive Surgery Rouen University HospitalUniversity of Rouen

AIM To evaluate the imaging course of Crohn's disease(CD) patients with perianal fistulas on long-term maintenance anti-tumor necrosis factor(TNF)-α therapy and identify predictors of deep remission.METHODS All patients with perianal CD treated with anti-TNF-α therapy at our tertiary care center were evaluated by magnetic resonance imaging(MRI) and clinical assessment. Two MR examinations were performed: at initiation of anti-TNF-α treatment and then at least 2 years after. Clinical assessment(remission, response and non-response) was based on Present's criteria. Rectoscopic patterns, MRI Van Assche score, and MRI fistula activity signs(T2 signal and contrast enhancement) were collected for the two MR examinations. Fistula healing was defined as the absence of T2 hyperintensity and contrast enhancement on MRI. Deep remission was defined as the association of both clinical remission, absence of anal canal ulcers and healing on MRI. Characteristics and imaging patterns of patients with and without deep remission were compared by univariate and multivariate analyses.RESULTS Forty-nine consecutive patients(31 females and 18 males) were included. They ranged in age from 14-70 years(mean, 33 years). MRI and clinical assessment were performed after a mean period of exposure to anti-TNF-α therapy of 40 ± 3.7 mo. Clinical remission, response and non-response were observed in 53.1%, 20.4%, and 26.5% of patients, respectively. Deep remission was observed in 32.7% of patients. Among the 26 patients in clinical remission, 10 had persisting inflammation of fistulas on MRI(T2 hyperintensity, n = 7; contrast enhancement, n = 10). Univariate analysis showed that deep remission was associated with the absence of rectal involvement and the absence of switch of anti-TNF-α treatment or surgery requirement. Multivariate analysis demonstrated that only the absence of rectal involvement(OR = 4.6; 95%CI: 1.03-20.5) was associated with deep remission.CONCLUSION Deep remission is achieved in approximately one third of patients on maintenan

关键词： Crohns 疾病肛门管磁性的回声成像肛门疾病 / 诊断 biotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

加 biotherapy/chemotherapy 的外科的切除术改进肝的变形黑瘤的幸存

引用

World Journal of Hepatology 2012年第11期4卷 305-310页

作者： Shun-Da Du Yi-Lei Mao Shao-Hua Li Xin-Ting Sang et al. Xin Lu Yi-Yao Xu Hai-Feng Xu Lin Zhao Chun-Mei Bai Shou-Xian Zhong Jie-Fu Huang Shun-Da Du Yi-Lei Mao Shao-Hua Li Xin-Ting Sang Xin Lu Yi-Yao Xu Hai-Feng Xu Shou-Xian Zhong Jie-Fu Huang Department of Liver Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China.

AIM: To analyze the correlation of treatment method with the outcome of all the hepatic metastatic mela-noma (HMM) patients from our hospital.METHODS: There were altogether nine cases of HMM that had been treated in the PUMCH hospital during the past 25 years, from December 1984 to February 2010. All of the cases developed hepatic metastasis from primary cutaneous melanoma. A retrospective review was performed on all the cases in order to draw informative conclusion on diagnosis and treatment in correlation with the prognosis. Clinical features including symptoms, signs, blood test results, Bultrasound and computed tomography (CT) imaging characteristics, and pathological data were analyzed in each case individually. A simple comparison was made on case by case basis instead of performing statistical analysis since the case numbers are low and patients were much diversified in each item that has been analyzed. Literatures on this subject were reviewed in order to draw a safe conclusion and found to be supportive to our finding in a much broad scope. RESULTS: There are six males and three females whose ages ranged 39-74 years old with an average of 58.8. Patients were either with or without symptoms at the time of diagnosis. The liver function and tumor marker exam were normal in all but one patient. The incidence of HMM does not affect liver function and was not related to virus infection status in the liver. Most of these HMM patients were also accompanied by the metastases of other locations, including lung, abdominal cavity, and cervical lymph nodes. Ultra-sound examinations showed lesions ranging 2-12 cm in diameter, with noor low-echo peripheral areola. Doppler showed blood flow appeared inside some tumors as well as in the surrounding area. CT image demonstrated low density without uniformed lesions, characterized with calcification in periphery, and en-hanced in the arterial phase. Contrast phase showed heterogeneous enhancement, with a density higher than normal liver tissue, which was especially appar-en

关键词： Malignant melanoma Hepatic metastatic tumor Hepatectomy Hepatic metastatic melanoma Prognosis biotherapy Chemotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioinhibition of diarrhogenic Gram-positive bacterial pathogens by potential indigenous probiotics

引用

Asian Pacific Journal of Tropical Medicine 2008年第2期1卷 7-11页

作者： Adenike A.O.Ogunshe Applied Microbiology and Infectious Diseases Department of Botany & MicrobiologyUniversity of IbadanIbadanNigeria

High level infant mortality rates and onset of drug resistance has led into the possible development of indigenous probiotics as alternative bacteriotherapy in the control of infantile bacterial diarrhoea.This study was to determine the in vitro inhibitory potential of four probiotic candidates obtained from Nigerian indigenous fermented foods and beverages and from faecal specimens of healthy infants on infantile Gram-positive diarrhogenic bacterial pathogens.Potential probiotic candidates,AAOOL4,L.reuteri AAOOCH1,L.plantarum AA0025NN and L.delbrueckii AAOOT20 were assayed for in vitro bactericidal effects on diarrhogenic bacterial test strains-Bacillus cereus 25S,B.cereus 32S,B.licheniformis 26S and B.licheniformis 39S.All the test strains inoculated into an industrial infant weaning food already seeded with the probiotic strains were significantly inhibited within 96 hours.L.acidophilus AAOOL4,L.reuteri AAOOCH1,L.plantarum AAOO25NN and L.delbrueckii AAOOT20 had in vitro bactericidal effects on bacteri isolates implicated in infantile diarrhoea,indicating the probiotic potential of the candidates.

关键词： bactericidal biotherapy diarrhoea infantile probiotics tropics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in non-surgical management of primary liver cancer

引用

World Journal of Gastroenterology 2014年第44期20卷 16630-16638页

作者： Xiao Chen Hai-Peng Liu Mei Li Liang Qiao Department of General Surgery Lanzhou University Second Hospital Key Laboratory of Digestive System Tumors of Gansu Province Storr Liver Unit Westmead Millennium Institute Department of Medicine and Western Clinical School University of Sydney

Hepatocellular carcinoma(HCC) is the fifth most common cancer and the third most common cause of cancer-related death worldwide. There have been great improvements in the diagnosis and treatment of HCC in recent years, but the problems, including difficult diagnosis at early stage, quick progression, and poor prognosis remain unsolved. Surgical resection is the mainstay of the treatment for HCC. However, 70%-80% of HCC patients are diagnosed at an advanced stage when most are ineligible for potentially curative therapies such as surgical resection and liver transplantation. In recent years, non-surgical management for unrespectable HCC, such as percutaneous ethanol injection, percutaneous microwave coagulation therapy, percutaneous radiofrequency ablation, transcatheter arterial chemoembolization, radiotherapy, chemotherapy, biotherapy, and hormonal therapy have been developed. These therapeutic options, either alone or in combination, have been shown to control tumor growth, prolong survival time, and improve quality of life to some extent. This review covers the current status and progress of non-surgical management for HCC.

关键词： Ablation therapy biotherapy Hepatocellu-lar carcin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Liver-specific therapies for metastases of neuroendocrine pancreatic tumors

引用

World Journal of Hepatology 2010年第10期2卷 367-373页

作者： Volker Fendrich Patrick Michl Nils Habbe Detlef Klaus Bartsch Department of Surgery Philipps-University Department of Gastroenterology Philipps-University

The presence or development of liver metastases in patients with neuroendocrine pancreatic tumors is the most important prognostic factor.Liver resection,transplantation and many different therapeutic approaches are d... 详细信息

关键词： Liver metastasis Neuroendocrine pancreatic tumor Liver resection Liver transplantation Chemotherapy biotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Adult Onset Still’s Disease: Articular Manifestations in Twenty Cases

引用

Open Journal of Clinical Diagnostics 2015年第2期5卷 41-45页

作者： Madiha Mahfoudhi Imen Gorsane Amel Gaieb Battikh Rafik Shimi Sami Turki Fathi Ben Hamida Taieb Ben Abdallah Internal medicine A department.Charles Nicolle Hospital TunisTunisia Research Unit of Kidney Diseases(LR00SP01) Charles Nicolle HospitalTunisTunisia

The adult onset Still’s disease is a rare inflammatory pathology of unknown pathogeny. The clinical features are variable. The diagnosis is difficult since exclusion of infectious, systemic and tumoral pathologies should be done. The articular complications are frequent and can be revelatory of this pathology. The articular prognosis depends on the diagnosis delay and the treatment efficiency. Our study aims to analyze different aspects of articular manifestations complicating adult onset Still’s disease to define epidemiological, clinical and evolving characteristics of these complications. It was a cross-sectional study concerning 20 cases of adult onset Still’s disease diagnosed from 1990 to 2015 in the internal medicine A department of Charles Nicolle Hospital in Tunis, meeting Yamaguchi criteria. We identified clinical, radiological, evolving and therapeutic profile of the articular manifestations occurred in these patients. There were 13 women and 7 men. The average age was 25 years. The arthralgias were reported in all cases;while, the arthritis interested fifteen patients. A hand deformation was found in four patients. A wrist ankylosis was noted in one case and a flexion elbow in one patient. The standard articular radiographs were normal in twelve cases. The treatment associated essentially non-steroidal anti-inflammatory and/or corticosteroids and/or methotrexate. Concerning the evolving profile, the monocyclic form was present in 25% of the cases, the intermittent form in 45% and the chronic articular form in 30% of our patients. The adult onset Still’s disease is rare and heterogeneous. The articular disturbances are frequent and have various outcomes.

关键词： Adult Onset Still’s Disease Arthritis Fever Corticosteroids biotherapy Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of Th17 cells in the pathogenesis of rheumatoid arthritis

引用

World Journal of Rheumatology 2013年第3期3卷 25-31页

作者： Katia Boniface Daniel Moynet M Djavad Mossalayi INSERM U1035 Dermatology group Immunology Laboratory Bordeaux Segalen University 33076 Bordeaux Cedex France

Since early description of CD4/CD8 T cell duality, continuous discovery of functional T lymphocyte subsets and their related cytokines constitutes major progress in our understanding of the immune response. T-lymphocyte derived lymphokines and environmental cytokines are essential for both innate and antigen-specific immune responses to a wide variety of agents. Following immune battle and aggression overcome, cytokines may return against neighbored cells/organs, causing pathogenic hypersensitivity reactions, including autoimmune diseases. Due to their cytokine production, CD4+ T helper lymphocyte subsets may be considered as one the major players of the immune response. Among CD4+ T cell subsets, the identification of interleukin-17-producing cells(Th17) led to better understanding of coordinated cytokine involvement during inflammatory reactions together with the subsequent clarification of complex interactions between these mediators. In this review, we discuss Th17 cell differentiation, functions, and the role of this cell subset during rheumatoid arthritis pathogenesis together with therapeutic strategies to control these cells.

关键词： Interleukin-17-producing cells CD4+T cells Arthritis Inflammation biotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：