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An engineered lamellar bone mimicking full-scale hierarchical architecture for bone regeneration

Bioactive Materials 2023年第9期27卷 181-199页

作者： Tao Yang Zhichao Hao Zhenzhen Wu Binxin Xu Jiangchen Liu Le Fan Qinmei Wang Yanshan Li Dongying Li Sangzhu Tang Chuanzi Liu Weichang Li Wei Teng Hospital of Stomatology Guanghua School of StomatologySun Yat-sen University and Guangdong Provincial Key Laboratory of StomatologyNo.56Lingyuan West RoadYuexiu DistrictGuangzhou510055China Department of Periodontology and Implantology Stomatological HospitalSchool of StomatologySouthern Medical UniversityGuangzhouChina Laboratory of Biomaterials Key Laboratory on Assisted CirculationMinistry of HealthCardiovascular DivisionThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina

Lamellar bone,compactly and ingeniously organized in the hierarchical pattern with 6 ordered scales,is the structural motif of mature *** hierarchical scale exerts an essential role in determining physiological behavior and osteogenic bioactivity of *** lamellar bone with full-scale hierarchy remains a longstanding ***,using bioskiving and mineralization,we attempt to engineer compact constructs resembling full-scale hierarchy of lamellar *** systematically investigating the effect of mineralization on physicochemical properties and bioactivities of multi-sheeted collagen matrix fabricated by bioskiving,the hierarchical mimicry and hierarchy-property relationship are *** prolongation of mineralization,hierarchical mimicry and osteogenic bioactivity of constructs are performed in a bidirectional manner,*** rising and then descending,which is supposed to be related with transformation of mineralization mechanism from nonclassical to classical *** mineralized 9 days can accurately mimic each hierarchical scale and efficiently promote *** analysis further reveals that this construct potently activates integrinα5-PI3K/AKT signaling pathway through mechanical and biophysical cues,and thereby repairing critical-sized bone *** present study provides a bioinspired strategy for completely resembling complex hierarchy of compact mineralized tissue,and offers a critical research model for in-depth studying the structure-function relationship of bone.

关键词： Full-scale hierarchy Lamellar bone bioskiving Mineralization Integrinα5-PI3K/AKT signaling Pathway

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