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bioseparation中心得到一笔研究资金

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生物技术通报 1985年第12期 13-13页

作者：王振江

美国得克萨斯大学与国家航空和航天局的 Johnson 航天中心签署了一项230万美元的合同,研究和发展分离细胞的技术,用以在空间制造细胞、蛋白质和激素,例如胰岛素和人生长激素。研究工作将在得克萨斯大学生物处理研究中心的 bioseparation... 详细信息

美国得克萨斯大学与国家航空和航天局的 Johnson 航天中心签署了一项230万美元的合同,研究和发展分离细胞的技术,用以在空间制造细胞、蛋白质和激素,例如胰岛素和人生长激素。研究工作将在得克萨斯大学生物处理研究中心的 bioseparation 实验室进行,Rich-

关键词：得克萨斯美国 bioseparation

Smart membranes for biomedical applications

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Chinese Journal of Chemical Engineering 2022年第9期35卷 34-45页

作者： Lin-Bing Zou Jue-Ying Gong Xiao-Jie Ju Zhuang Liu Wei Wang Rui Xie Liang-Yin Chu School of Chemical Engineering Sichuan UniversityChengdu 610065China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China

Smart membranes with tunable permeability and selectivity have drawn widespread attention because of their unique biomimetic *** by incorporating various stimuli-responsive materials into membrane substrates,smart membranes could self-adjust their physical/chemical properties(such as pore size and surface properties)in response to environmental signals such as temperature,pH,light,magnetic field,electric field,redox and specific ions/*** smart membranes show great prospects in biomedical applications ranging from controlled drug release to bioseparation and tissue *** this review,three controlled release models realized by different designed smart membranes are emphatically introduced,and then smart membranes for biological separation and controlled cell culture are introduced and discussed *** last,the existing challenges of smart membranes for biomedical applications are briefly summarized,and future research topics are suggested.

关键词： Membranes Polymers Smart materials Controlled release bioseparation Cell culture

Use of biopolymers in wastewater treatment:A brief review of current trends and prospects

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Chinese Journal of Chemical Engineering 2023年第12期64卷 292-320页

作者： Ahmed M.Elgarahy M.G.Eloffy Eric Guibal Huda M.Alghamdi Khalid Z.Elwakeel Egyptian Propylene and Polypropylene Company(EPPC) Port-SaidEgypt Environmental Chemistry Division Environmental Science DepartmentFaculty of SciencePort Said UniversityPort SaidEgypt National Institute of Oceanography and Fisheries(NIOF) CairoEgypt Polymers Composites and Hybrids(PCH) C2MAIMT Mines AlesAlèsFrance University of Jeddah College of ScienceDepartment of ChemistryJeddahSaudi Arabia

Indeed,polymeric materials have thrived in worldwide sectors over the last five decades due to their versatility and durability,to the point that we can no longer envisage a product that does not contain ***,many synthetic polymers that have been produced are mostly sourced from petroleum and coal as raw materials,making them environmentally incompatible because they cannot be integrated with what is a natural recycling *** of the most important aspects of the transition to a circular bioeconomy(CBE)is the provision of more sustainable strategies for resource and waste *** the environmental consequences associated with petroleum-based polymers(PBPs),natural biopolymers,originating from biomass,can be conceived as a promising solution to gradually replace the PBPs,and address,and resolve the potential challenges and prevailing research gaps in the *** biopolymers have significant advantages over PBPs in terms of low-cost/zero-cost precursors,environmental friendliness,and *** present review dissects the sources,synthesis pathways,structures,characterization,and employment of biopolymers and their composites in water and wastew-ater treatment applications via different ***,the CBE model framework proposes potential approaches to applying CBE principles in the wastewater management sector,with a heavy emphasis on not only technology but also organizational and societal *** sum up,the reliance on biopolymers can be considered a crucial tool for assessing the global progress toward CBE,as well as future environmental management and planning.

关键词： Biopolymers Biomass bioseparation Coagulation Photocatalysis Sustainability

Ethanol shock enhances the recovery of anthocyanin from lowbush blueberry

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Chinese Journal of Chemical Engineering 2020年第12期28卷 3096-3102页

作者： Nueraili Maimaiti Niyazi Aili M.Kamran Khan Zhigang Tang Guoqiang Jiang Zheng Liu Key Laboratory of Industrial Biocatalysis Ministry of EducationBeijing 100084China Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

Deactivation of polyphenol oxidase(PPO)in natural products is essential for downstream processing of functional molecules used as food or food additives,particularly those served as *** the present work,we identified two proteins with PPO activity from lowbush blueberry using ammonium sulphate precipitation and chromatography *** of these proteins was studied using aqueous solutions of ethanol of different *** PPO activity was recovered after ethanol removal for the protein samples previously soaked in a lowconcentration ethanol solution.A complete and unrecoverable deactivation of the proteins was achieved using ethanol with concentration over 70%(v/v),as manifested by the significant changes in circular dichroism(CD)and fluorescence spectroscopy *** on these findings,we propose a new extraction process for blueberry anthocyanin,in which an ethanol shock,*** blueberry fruit in a 70%(v/v)ethanol solution for 1 h,is implemented before subsequent *** new process increases the anthocyanin yield by 55%in comparison to that without the ethanol shock.

关键词： Anthocyanin Lowbush blueberry Ethanol shock Polyphenol oxidase bioseparation Enzyme deactivation

Preparation of magnetic iron/mesoporous silica composite spheres and their use in protein immobilization

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中国有色金属学会会刊：英文版 2009年第S3期19卷 605-610页

作者：王平赵建青蒋智杰刘运春刘述梅 School of Materials Science and Engineering South China University of Technology

The iron/silica magnetic composite spheres were prepared by electrochemical method and reduced in hydrogen atmosphere at different temperatures. The morphology and structure of the composite were characterized by SEM, TEM and XRD. The iron/silica microspheres exhibit essential ferromagnetic behavior characterized by magnetometry. After being coated with silica in sodium silicate solution by acidifying technology, the surface of these magnetic composite spheres is with amino-silane coupling agent for their attachment to affinity ligands. Bovine serum albumin (BSA) was covalently immobilized onto the amino-silane modified magnetic silica supports by the glutaraldehyde method. The influence of pH, ionic strength as well as the initial protein concentration on BSA immobilization was studied. The results show that such amino-silane modified magnetic composite spheres are the effective supports for bioseparation and the maximum BSA immobilization capacity (up to 87.4 mg/g) is obtained in 0.1 mol/L phosphate buffer at pH 5.0.

关键词： magnetic composite sphere electrochemical synthesis bovine serum albumin immobilization bioseparation

Selective Removal of Low-Density Lipoproteins from Blood by Induced Precipitation with AAS in Vitro(Ⅰ)

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Chinese Journal of Chemical Engineering 1998年第1期6卷 77-82页

作者：方波江体乾 Chemical Engineering Research Centre East China University of Science and Technology

1 INTRODUCTION It’s evident that high level of cholesterol in blood is associated with the formation and devel-opment of familial hypercholestrolemia(FH)and atherosclerosis(AS).In general,choles-terol in blood is mainly combined with low-density lipoproteins(LDL),very low-densitylipoproteins(VLDL)and high density lipoproteins(HDL).About 60%-80% cholesterolexists in LDL and *** and VLDL have been recognized as the principal

关键词： bioseparation plasmapheresis LDL-purification low-density lipoproteins

Ionic liquid-based salting-out extraction of bio-chemicals

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Chinese Journal of Chemical Engineering 2021年第2期34卷 185-193页

作者： Jianying Dai Yaqin Sun Zhilong Xiu School of Bioengineering Dalian University of TechnologyDalian 116024China

Ionic liquids(ILs)are known as green solvents,and have been widely used in the dissolution and transformation of biopolymers,the extraction of bioactive compounds and metal ions,and the capture of SO2 or ***,less attention was given to the separation of bio-based chemicals,such as diols and organic ***-based chemicals can be efficiently separated by organic solvent-based salting-out extraction(SOE)from fermentation broths,while organic solvents are normally unfriendly to environment and process safety in commercialized production due to their toxicity or/and *** recent years,the IL-based SOE system has been explored in the separation of bio-based chemicals as an alternative of organic solvent-based SOE *** this review,the progress of IL-based SOE of biobased chemicals has been summarized,including the effect of ILs structure on the formation of aqueous two phases,and the influences of ILs structure and concentration,temperature and pH on the partition behaviors of target products and ILs as well as removal of *** of bio-based chemicals could be distributed into the IL-rich phase with high recovery,while the partition behaviors of bio-based chemicals are sometimes different from that in organic solvent-based SOE *** the results of ILbased SOE are promising,further studies are still required in the increased selectivity of target products over by-products,recovery and recycling of ILs,and the separation between ILs and bio-based ***,three kinds of integrated bioprocesses would be developed on basis of utilization of ILs as extractant for SOE,catalyst for condensation reaction and solvent for pretreatment of lignocellulose.

关键词： Downstream processing bioseparation Ionic liquids Salting-out extraction Partition behavior Bio-based chemicals

Antioxidant activity of phlorotannins from brown algae

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International Journal of Agricultural and Biological Engineering 2017年第6期10卷 184-191页

作者： Xin Liu Wenqiao Yuan Ratna Sharma-Shivappa John van Zanten Department of Biological and Agricultural Engineering North Carolina State UniversityRaleighNC 27695USA Golden LEAF Biomanufacturing Training&Education Center North Carolina State UniversityRaleighNC 27695USA

The antioxidant activity of the phlorotannins extracted from five marine algaespecies(Saccharina latissima,Alaria esculenta,Laminaria digitata,Fucus vesiculosusand Ascophyllum nodosum)was *** phlorotannin groups,including soluble,membrane-bound,and extracted membrane-bound phlorotannins obtained by two solvent extraction methods were investigated for their DPPH radical scavenging *** *** the highest phlorotannin yield(14.83 mg-extract/g-algae and 12.80 mg-extract/g-algae,respectively)among the five *** soluble phlorophannin(SP),membrane-bound phlorotannin(MP)and extracted membrane-bound phlorotannin(eMP)extracts all showed equal or greater DPPH radical scavenging activity than the commercial antioxidants of butylated hydroxytoluene and ascorbic *** antioxidant potential that combines phlorotannin yield and antioxidant activity of the MP extracts of *** ***(5890mL/g and 5278 mL/g algae,respectively)were higher than those of SP and eMP,suggesting that the MPs of *** *** great potential to be used as *** extraction methods also showed significantly different effects on the antioxidant activity of the phlorotannin extracts.

关键词： brown algae phlorotannin antioxidant activity antioxidant bioseparation polyphenol solvent extraction methods

RIGID GIGAPOROUS CHROMATOGRAPHIC MEDIA AND THEIR POTENTIAL IMPACT ON DOWNSTREAM PROCESSING

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China Particuology 2005年第6期3卷 349-353页

作者： Tingyue Gu Weiqing Zhou Guanghui Ma Zhiguo Su Department of Chemical Engineering Ohio University Athens Ohio 45701 USA Institute of Process Engineenng Chinese Academy of Sciences Beijing 100080 R R. China

More and more biomolecules are being produced by the biotechnology industry for applications ranging from medicine and food to engineering materials. Liquid chromatography plays a center-stage role in a typical downstream process producing biomolecules such as recombinant proteins. Rigid gigaporous media are porous particles possessing large transecting through-pores with a pore-to-particle diameter ratio of dpore/dparticle〉 0.01. They allow convective flow in the large through-pores, while the smaller diffusion-pores （typically several hundred angstroms in size） supply the needed surface areas. Because of the transecting gigapores, a portion of the mobile phase flows through the pores in addition to fluid flow in the interstitial spaces between the particles in a packed-bed column. This considerably lowers the operating column pressure drop. This lower pressure drop makes axial-direction scale-up of chromatographic columns possible to avoid pancake columns that invariably degrade separation resolution. The large gigapores also make the binding sites on the diffusion pore surfaces more accessible, thus increasing the loading capacity of large protein molecules that can be hindered sterically if only diffusion pores are present. This work discusses the development of rigid gigaporous media and their potential impact on the design of multi-stage downstream process from the angle of multi-scale analysis.

关键词： Gigapore chromatography bioseparation downstream process multi-scale diffusion