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Tissue resonance interaction accurately detects colon lesions: A double-blind pilot study

World Journal of Gastroenterology 2015年第25期21卷 7851-7859页

作者： Maria P Dore Marcello O Tufano Giovanni M Pes Marianna Cuccu Valentina Farina Alessandra Manca David Y Graham Dipartimento di Medicina Clinica e Sperimentale University of Sassari Baylor College of Medicine Michael E De Bakey VAMC 2002 Holcombe Blvd Houston Tx 77030 United States

AIM: To investigated the performance of the tissue resonance interaction method(TRIM) for the noninvasive detection of colon ***: We performed a prospective single-center blinded pilot study of consecutive adults undergoing colonoscopy at the University Hospital in Sassari, Italy. Before patients underwent colonoscopy, they were examined by the TRIMprobe which detects differences in electromagnetic properties between pathological and normal tissues. All patients had completed the polyethylene glycol-containing bowel prep for the colonoscopy procedure before being screened. During the procedure the subjects remained fully dressed. A hand-held probe was moved over the abdomen and variations in electromagnetic signals were recorded for 3 spectral lines(462-465 MHz, 930 MHz, and 1395 MHz). A single investigator, blind to any clinical information, performed the test using the TRIMprob system. Abnormal signals were identified and recordedas malignant or benign(adenoma or hyperplastic polyps). Findings were compared with those from colonoscopy with histologic confirmation. Statistical analysis was performed by χ2 ***: A total of 305 consecutive patients fulfilling the inclusion criteria were enrolled over a period of 12 months. The most frequent indication for colonoscopy w a s a b d o m i n a l p a i n( 3 3 %). T h e T R I M p r o b w a s well accepted by all patients; none spontaneously complained about the procedure, and no adverse effects were observed. TRIM proved inaccurate for polyp detection in patients with inflammatory bowel disease(IBD) and they were excluded leaving 281 subjects(mean age 59 ± 13 years; 107 males). The TRIM detected and accurately characterized all 12 adenocarcinomas and 135/137 polyps(98.5%) including 64 adenomatous(100%) found. The method identified cancers and polyps with 98.7% sensitivity, 96.2% specificity, and 97.5% diagnostic accuracy, compared to colonoscopy and histology analyses. The positive predictive value was 9

关键词： Colon cancer screening bioscanner noninvasivediagnosis Electromagnetic Resonance

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