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Nonlinear Anisotropic Composite biomechanical modeling of Human Skin

Journal of Shanghai Jiaotong university(Science) 2010年第3期15卷 363-367页

作者：黄真周岱任秋实 School of Naval Architecture Ocean and Civil Engineering College of Life Science and Biotechnology Shanghai Jiaotong University

A 3D nonlinear anisotropic composite biomechanical modeling of human skin was developed according to existing biomechanical experimental results,which can provide insights into the important structure-function relationship and parameters in skin tissue.A structural approach determines the macroscopic mechanical response of the skin tissue from its underlying structural *** collagen fibers were embedded into a block of elastic gel *** constitutive matrix of skin tissue consisted of both of collagen fiber and elastic gel block according to the rule that the collagen fibers were undulated with the ability to resist load only when completely *** nonlinear and anisotropic mechanical responses were largely due to varying degree of fiber *** distributions were used to determine the extent of fiber *** comparison of stress-strain plots between the modeling and experimental results showed the good coordination of the *** model parameters were discussed to compute the macroscopic mechanical response when the tissue block was subject to a simple deformation mode.

关键词： human skin biomechanical modeling nonlinear and anisotropic properties

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Advanced 4-dimensional cone-beam computed tomography reconstruction by combining motion estimation, motioncompensated reconstruction, biomechanical modeling and deep learning

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Visual Computing for Industry,Biomedicine,and Art 2019年第1期2卷 221-235页

作者： You Zhang Xiaokun Huang Jing Wang Division of Medical Physics and Engineering Department of Radiation OncologyUT Southwestern Medical Center2280 Inwood RoadDallasTX 75390USA

4-Dimensional cone-beam computed tomography(4D-CBCT)offers several key advantages over conventional 3DCBCT in moving target localization/delineation,structure de-blurring,target motion tracking,treatment dose accumulation and adaptive radiation ***,the use of the 4D-CBCT in current radiation therapy practices has been limited,mostly due to its sub-optimal image quality from limited angular sampling of conebeam *** this study,we summarized the recent developments of 4D-CBCT reconstruction techniques for image quality improvement,and introduced our developments of a new 4D-CBCT reconstruction technique which features simultaneous motion estimation and image reconstruction(SMEIR).Based on the original SMEIR scheme,biomechanical modeling-guided SMEIR(SMEIR-Bio)was introduced to further improve the reconstruction accuracy of fine details in lung *** improve the efficiency of reconstruction,we recently developed a U-net-based deformation-vector-field(DVF)optimization technique to leverage a population-based deep learning scheme to improve the accuracy of intra-lung DVFs(SMEIR-Unet),without explicit biomechanical *** of each of the SMEIR,SMEIR-Bio and SMEIR-Unet techniques were included in this study,along with the corresponding results comparing the reconstruction accuracy in terms of CBCT images and the *** also discussed the application prospects of the SMEIR-type techniques in image-guided radiation therapy and adaptive radiation therapy,and presented potential schemes on future developments to achieve faster and more accurate 4D-CBCT imaging.

关键词： Cone-beam computed tomography Image reconstruction Motion estimation biomechanical modeling Deep learning

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Cranio-maxillofacial surgery simulation based on pre-specified target face configurations

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第7期11卷 504-513页

作者： Sheng-zheng WANG Jie YANG James C. GEE Institute of lmage Processing & Pattern Recognition Shanghai Jiao Tong University Shanghai 200240 China Merchant Marine College Shanghai Maritime University Shanghai 200235 China Department of Radiology University of Pennsylvania Philadelphia 19104 PA USA

This paper presents a novel method for assisting surgeons in automatically computing an optimal surgical plan by directly specifying the desired correction to a facial outline. First, the desired facial appearance is designed using a 3D sculpturing tool, while the cut regions of the skull are defined based on facial anatomy. Then, the deformation of the face meshes is performed using an improved biomechanical model in which virtual external forces are driven by the displacements corresponding to the differences of node coordinates between the original and specified face meshes, and free nodes and fixed nodes are defined in terms of the contact surfaces between the soft tissues and the bones within the cut regions. Finally, the shape of the contact surfaces is updated following the deformation of the soft tissues. After registering the deformable contact surfaces and the cut surfaces, the final positions of the cut bones are estimated. Evaluation of preliminary experimental results quantitatively shows the effectiveness of the proposed approach.

关键词： Surgical planning biomechanical modeling Soft tissue deformation Plastic surgery

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