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Exercise-Dependent Modulation of Bone Metabolism and Bone Endocrine Function:New Findings and Therapeutic Perspectives

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Journal of Science in Sport and Exercise 2019年第1期1卷 20-28页

作者： Giovanni Lombardi IRCCS Istituto Ortopedico Galeazzi Laboratory of Experimental Biochemistry and Molecular BiologyVia Riccardo Galeazzi420161 MilanItaly Department of Physiology and Pharmacology Gdańsk University of Physical Education and SportKazimierza Górskiego 180-336 GdańskPomorskiePoland

Physical inactivity is the fourth leading cause of mortality worldwide;regardless of geographic location and income,it is a contributing risk factor to the other three *** activity is really a drug,a poly-pill;its“regular use”can reduce this risk throughout the activation of a plethora of responses in virtually all the body *** beneficial effects of physi-cal activity on cardiovascular function and hemodynamics are mainly mediated by skeletal muscle,adipose tissue and the immune system via the usage,delivery and distribution of metabolic substrates and improvement in inflammatory *** is emerging evidence for exercise-dependent changes in bone metabolism as well;with improved bone quality,reduced fracture risk and increased bone endocrine function,the last of which modulates energy metabolism through its effects on pancreatic islet cells,skeletal muscle and adipose *** endocrine function relies on the integration of biomechani-cal stimuli and endocrine signals from other organs and *** I review current concepts about exercise-dependent modulation of bone endocrine function and its beneficial effects on whole-body *** molecular mechanisms have been identified that support this exercise-stimulated bone-mediated metabolic effect and,among these,Wnt signaling,fibroblast growth factor-23,bone morphogenic protein-7,osteocalcin,RANK/RANKL/OPG axis,and lipocalin-2 gave the largest *** conclusion,beside the controversies surrounding technical aspects of the exercise,the efficacy of physi-cal activity in preventing/treating metabolic and inflammatory dysfunctions also passes throughout the bone.

关键词： Bone metabolism Bone endocrine function Osteokines biomechanical loading

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