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A biological safety evaluation on reclaimed water reused as scenic water using a bioassay battery

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Journal of Environmental Sciences 2011年第10期23卷 1611-1618页

作者： Dongbin Wei Zhuowei Tan Yuguo Du State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

An assessment method based on three toxicity tests （algae growth inhibition, daphnia immobilization and larval fish toxicity） was used to screen the biological safety of reclaimed water which was reused as sole replenishment for scenic water system in a park （SOF Park） in northern China. A total of 24 water samples were collected from six sites of water system in the SOF Park in four different seasons. The results indicated that：（1） the reclaimed water directly discharged from a reclamation treatment plant near the SOF Park as influent of park had relatively low biological safety （all samples were ranked as C or D）; （2） the biological safety of reclaimed water was improved greatly with the ecological reclamation treatment processes composing of artificial wetland system and followed oxidation pond system; （3） the biological safety of reclaimed water in the main lake of SOF Park kept at a health status during different seasons （all samples were ranked as A）; （4） there was some certain correlation （R2= 0.5737） between the sum of toxicity scores and dissolved organic carbon for the studied water samples. It was concluded that the assessment method was reliable to screen the safety of reclaimed water reused as scenic water, and the reclaimed water with further ecological purification processes such as artificial wetland and oxidation pond system can be safely reused as scenic water in park.

关键词： biological safety water quality index bioassay reclaimed water

biological safety Evaluation of White Insect Tea in Guizhou

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Plant Diseases and Pests 2010年第2期1卷 55-57,62页

作者：杨立昌乙引贵州师范大学生命科学学院贵州贵阳550001

[Objective] The biological safety of white insect tea in Xifeng County of Guizhou Province was evaluated in order to provide a scientific basis for the development of white insect tea. [Method] Acute toxicity test in mice, Ames microbiological test and mouse bone marrow polychromatic erythrocyte micronucleus test were done with wild white inset tea produced in Xifeng County. At the same time, the contents of six kinds of limit pollutants were determined, including Pb,Cr,Cd,Hg,As,and F-. [Result] The results showed that white insect tea had LD505.0 g/kg（BW）in acute toxicity test, negative response in Ames test and microkernel test. In addition, the contents of Pb,Cr,Cd,Hg,As,and F- in the white inset tea were 2.20,1.06,0.46,0.09,0.71,21.50 mg/kg, much less than the national standard of tea （GB2762-2005,NY 659-2003）. [Conclusion] The white insect tea produced in Xifeng County of Guizhou Province is non-toxic, and good for human as beverage.

关键词： White insect tea biological safety Toxicology Evaluation

Spinal cord biological safety of image-guided radiation therapy versus conventional radiation therapy

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Neural Regeneration Research 2012年第35期7卷 2755-2760页

作者： Wanlong Xu Xilinbaoleri Hao Liu Ruozheng Wang Jingping Bai The Affiliated Tumor Hospital of Xinjiang Medical University People's Hospital of Xinjiang Uygur Autonomous Region

Tumor models were simulated in purebred Beagles at the T9-10 levels of the spinal cord and treated with spinal image-guided radiation therapy or conventional radiation therapy with 50 or 70 Gy total radiation. Three months after radiation, neuronal injury at the T9-10 levels was observed, including reversible injury induced by spinal image-guided radiation therapy and apoptosis induced by conventional radiation therapy. The number of apoptotic cells and expression of the proapoptotic protein Fas were significantly reduced, but expression of the anti-apoptotic protein heat shock protein 70 was significantly increased after image-guided radiation therapy compared with the conventional method of the same radiation dose. Moreover, the spinal cord cell apoptotic index positively correlated with the ratio of Fas/heat shock protein 70. These findings indicate that 3 months of radiation therapy can induce a late response in the spinal cord to radiation therapy; image-guided radiation therapy is safer and results in less neuronal injury compared with conventional radiation therapy.

关键词： Image-guided radiation therapy conventional radiation therapy spinal cord neurons apoptosis Fas heat shock protein 70 biological safety vertebral body tumor

Research of the Application of Nanometer Materials in Sports Engineering and the biological safety

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International English Education Research 2014年第7期 115-117页

作者： Lianbo Yang Northeast Dianli University Jilm Province China 132012

In the modern material engineering, the use of nanometer materials has entered the highly and intensively utilized stage, so new nanometer materials have been continuously found to replace the traditional ordinary materials. The so-called nanometer materials have the size within l - 100nm in thickness, which originates from the 1980s. At that time, nanometer materials didn＇t have a proper development due to the economic level. t towever, with the support of science and technology, this technology has undergone tremendous changes in the related fields. There have been increasing expansion in the kinds and the width in use of the nanometer materials, so have the research of nanometer materials. In this paper, we will briefly analyze the application ofnanometer materials in the sports engineering.

关键词： nanometer materials Sports engineering biological safety

Study of biological safety of scaffold material with heterologous deproteinized bone

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Chinese Journal of Traumatology 2006年第4期9卷 234-237页

作者：刘雷唐康来杨柳简月奎李起鸿 Center for Joint Surgery Southwest Hospital Third Military Medical University

To evaluate the biological safety of manufactured heterologous deproteinized bone and to provide an experimental basis for clinical applications. Methods ： Deproteinized bone （ 10 mm） and leaching liquor were made from pig ribs with a series of physical and chemical methods, then were evaluated through acute and subacute toxicity test, hemolysis test, pyrogen test, intracutaneous test, intramuscular implantation test and cytotoxity test. Results ： No obvious toxicity, hemolysis, pyrogenic characteristics, skin irritation, inflammatory reaction after intramusclar implantation and cytotoxity were observed. Conclusions： The heterologous deproteinized bone has good biological safety and meets all the demands of scaffold material for tissue engineering.

关键词： Transplantation, heterogeneous Tissue engineering biological safety

Development of a large-scale isolation chamber system for the safe and humane care of medium-sized laboratory animals harboring infectious diseases

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第10期11卷 771-778页

作者： Xin PAN Jian-cheng QI Ming LONG Hao LIANG Xiao CHEN Han LI Guang-bo LI Hao ZHENG Department of Microbiology the Second Military Medical University Shanghai 200433 China

The close phylogenetic relationship between humans and non-human primates makes non-human primates an irreplaceable model for the study of human infectious *** this study,we describe the development of a large-scale automatic multi-functional isolation chamber for use with medium-sized laboratory animals carrying infectious *** isolation chamber,including the transfer chain,disinfection chain,negative air pressure isolation system,animal welfare system,and the automated system,is designed to meet all biological safety *** create an internal chamber environment that is completely isolated from the exterior,variable frequency drive blowers are used in the air-intake and air-exhaust system,precisely controlling the filtered air flow and providing an air-barrier protection.A double door transfer port is used to transfer material between the interior of the isolation chamber and the outside.A peracetic acid sterilizer and its associated pipeline allow for complete disinfection of the isolation *** of the isolation chamber parameters can be automatically controlled by a programmable computerized menu,allowing for work with different animals in different-sized cages depending on the research *** large-scale multi-functional isolation chamber provides a useful and safe system for working with infectious medium-sized laboratory animals in high-level bio-safety laboratories.

关键词： Multi-function Medium-sized animal Isolation chamber biological safety

Surface charge-convertible quaternary ammonium salt-based micelles for in vivo infection therapy

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Chinese Chemical Letters 2021年第5期32卷 1743-1746页

作者： Dengfeng He Yifeng Tan Pengfei Li Yadong Luo Yuhong Zhu Yunlong Yu Jiali Chen Ning Ning Shiyong Zhang National Engineering Research Center for Biomaterials and College of Chemistry Sichuan UniversityChengdu 610064China West China Hospital Sichuan UniversityChengdu 610041China

Quaternary ammonium salts(QASs) are excellent candidates for treating stubborn bacterial infections caused by biofilms due to their high sterilization efficiency and potential inhibition of the development of drug ***,the inherent toxicity of QASs,including cytotoxicity,protein absorption and hemolysis,severely limits their applications in ***,a charge-co nvertible quaternary ammonium salt-based micelle(QAS-SL@CM) was constructed by co-assembly of two amphiphiles with opposite charges and shell cross-linking *** toxicity of the QAS-SL@CM could be greatly reduced towa rds human cells contrast to the corresponding *** response to the acidic environment at infection sites,the surface charge of QAS-SL@CM could be immediately changed to positive and then target to negatively charged *** re,β-thiopropionate bonds on QAS-SL@CM could also be disintegrated under acid environment to release QASs to kill ***,the QAS-SL@CM showed significant therapeutic effect in mice subcutaneous abscesses models without interference with normal ***,a surface adaptive micelle constructed by charge-convertible strategy has been developed to ove rcome the cytotoxicity of QAS s,and could intelligently respond to the microenvironment of infected wound for in vivo infection therapy,which shows promising application in clinic.

关键词： Quaternary ammonium salt Co-assembled micelle Biofilm biological safety In vivo infection

Biosafety and biobanking: Current understanding and knowledge gaps

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Biosafety and Health 2021年第5期3卷 244-248页

作者： Julie Roux Maissa Zeghidi Stephanie Villar Zisis Kozlakidis World Health Organization International Agency for Research on CancerLyonFrance Ecole Supérieure de Biologie-Biochimie-Biotechnologies UniversitéCatholique de LyonLyonFrance

Infectious disease outbreaks,such as'Coronavirus disease 20190(COVID-19),can constitute major global health threats with far-reaching *** outbreaks develop,the international scientific community must provide high-quality scientific research-ready biological samples to solve the existing clinical and epidemiological questions to better combat the *** examples are provided by dedicated biobank facilities,the latter collecting increasingly high volumes of biological ***,the more significant concentrations of infectious or potentially infectious biological materials can create a safety *** current short report describes the first attempt to identify the published scientific works on biobanking and *** broad thematic areas have been identified:the physical security relevant to staff and sample integrity,the data safety aspects,and the governance parameters relating to the previous *** the current publications reflect a broad alignment with existing standards and best practices in the biobanking field,they also demonstrate an opportunity for further in-depth work on this field in the post-COVID-19 era.

关键词： Biosafety Biobank Data safety biological safety safety regulations

Genomovars of Burkholderia cepacia Complex from Rice Rhizosphere and Clinic in China

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Rice science 2007年第3期14卷 229-234页

作者： Lou Miao miao ZHANG Li xin Su Ting XIE Guan lin State Key Laboratory of Rice Biology Zhejiang UniversityHangzhou310029China

Burkholderia cepacia is regarded as a genetically distinct but phenotypically similar bacteria group referring to Burkholderia cepacia complex （Bcc）, which is found not only in clinic but also in rice growing environment. It is very important in microbial safety of rice for us to understand the genomovar status of Bcc. Genomovar analysis was performed among 87 Bcc isolates by means of Hae Ⅲ-recA RFLP assays and species-specific PCR tests. Three genomovars were found from the rice rhizosphere including Ⅰ, ⅢB and V, and genomovar V was predominant. Genomovars Ⅰ, ⅢA and ⅢB existed in the clinical samples, and genomovar ⅢA was the most popular. It showed that genomovar composition was different between the Bcc strains from the rice rhizosphere and clinical environment. Simultaneously, the results revealed the genetic diversity of Bcc strains from the rice rhizosphere, and genomovar Ⅲ referred as virulent species in clinic also existed in the rice rhizosphere.

关键词： Burkholderia cepacia complex rice rhizosphere clinic genomovars diversity biological safety biological control risk assessment