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The biological effect of recombinant humanized collagen on damaged skin induced by UV-photoaging:An in vivo study

Bioactive Materials 2022年第5期7卷 154-165页

作者： Jing Wang He Qiu Yang Xu Yongli Gao Peijie Tan Rui Zhao Zhanhong Liu Yajun Tang Xiangdong Zhu Chongyun Bao Hang Wang Hai Lin Xingdong Zhang National Engineering Research Center for Biomaterials Sichuan UniversityChengduSichuan 610064China College of Biomedical Engineering Sichuan UniversityChengduSichuan 610064China West China School/Hospital of Stomatology Sichuan UniversityChengduSichuan 610064China

The application of medical devices to repair skin damage is clinically accepted and natural polymer enjoys an important role in this field,such as collagen or hyaluronic acid,etc.However,the biosafety and efficacy of these implants are still challenged.In this study,a skin damage animal model was prepared by UV-photoaging and recombinant humanized type Ⅲ collagen(rhCol Ⅲ)was applied as a bioactive material to implant in vivo to study its biological effect,comparing with saline and uncrosslinked hyaluronic acid(HA).Animal skin conditions were non-invasively and dynamically monitored during the 8 weeks experiment.Histological observation,specific gene expression and other molecular biological methods were applied by the end of the animal experiment.The results indicated that rhCol Ⅲ could alleviate the skin photoaging caused by UV radiation,including reduce the thickening of epidermis and dermis,increase the secretion of Collagen Ⅰ(Col Ⅰ)and Collagen Ⅲ(Col Ⅲ)and remodel of extracellular matrix(ECM).Although the cell-material interaction and mechanism need more investigation,the effect of rhCol Ⅲ on damaged skin was discussed from influence on cells,reconstruction of ECM,and stimulus of small biological molecules based on current results.In conclusion,our findings provided rigorous biosafety information of rhCol Ⅲ and approved its potential in skin repair and regeneration.Although enormous efforts still need to be made to achieve successful translation from bench to clinic,the recombinant humanized collagen showed superiorities from both safety and efficacy aspects.

关键词： Recombinant collagen TypeⅢcollagen Skin regeneration Safety and efficacy biological effect

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A new horizon for neuroscience:terahertz biotechnology in brain research

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Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping Pu Yu Wu Zhongjie Zhu Hongwei Zhao Donghong Cui Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National Facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain sciences.In this article,we review the development of terahertz biotechnology and its applications in the field of neuropsychiatry.Available evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin deficit.In vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric diseases.Although the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic applications.However,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical applications.This review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology

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Nano Lanthanum Oxide Preparation by Alkalescent Ammonium Citrate System and Its Primary biological effect

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Journal of Rare Earths 2004年第6期22卷 913-916页

作者：王甲辰杨军刘向生黄小卫范玉斌伍艳平 Beijing General Research Institutes for Nonferrous Metals Beijing 100088 China National Rare Earth Center for Agriculture Beijing 100088China Grirem Advanced Materials Co. Ltd Beijing 100088China

Using alkalescent ammonium(AAC)as precipitatnt, the diameter of nano La_2O_3 powder with diameter in 80 nm and less was prepared by the method of homogeneous precipitation, and reactant concentration, temperature and pH were studied and confirmed. The best precipitated concentration is from 0.2 to 0.5 mol·L^(-1), and the diameter of compounded powder turns small as the temperature gradually becomes high, and the pH from 6 to 8 is the best and the concentration of precipitant does not affect the diameter of compounded powder significantly. Meanwhile, most experiments lasting for fifty days in the greenhouse, and the results are 0.2 g·kg^(-1) nano La_2O_3 powder is enorgh for increasing biomass by 133% compared with that of the CK.

关键词： nano La_2O_3 alkalescent ammonium citrate homogeneous precipitation biological effect rare earths

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Investigation and assessment of micropollutants and associated biological effects in wastewater treatment processes

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Journal of Environmental Sciences 2020年第8期32卷 119-127页

作者： Xiaoyan Y.Ma Ke Dong Lei Tang Yongkun Wang Xiaochang C.Wang Huu Hao Ngo Rong Chen Na Wang International Science&Technology Cooperation Center for Urban Alternative Water Resources Development Key Lab of Northwest Water ResourceEnvironment and EcologyMOEEngineering Technology Research Center for Wastewater Treatment and ReuseShaanxi ProvinceShaanxi Key Laboratory of Environmental EngineeringXi’an University of Architecture and TechnologyXi’an 710055China School of Civil and Environmental Engineering Faculty of Engineering and Information TechnologyUniversity of Technology SydneyBroadwayNSW 2007Australia School of Architecture and Civil Engineering Xi’an University of Science and TechnologyXi’an 710054China

Currently,the wastewater treatment plants(WWTPs)attempt to achieve the shifting from general pollution parameters control to reduction of organic micropollutants discharge.However,they have not been able to satisfy the increasing ecological safety needs.In this study,the removal of micropollutants was investigated,and the ecological safety was assessed for a local WWTP.Although the total concentration of 31 micropollutants detected was reduced by 83%using the traditional biological treatment processes,the results did not reflect chemicals that had poor removal efficiencies and low concentrations.Of the five categories of micropollutants,herbicides,insecticides,and bactericides were difficult to remove,pharmaceuticals and UV filters were effectively eliminated.The specific photosynthesis inhibition effect and non-specific bioluminescence inhibition effect from wastewater were detected and evaluated using hazardous concentration where 5%of aquatic organisms are affected.The photosynthesis inhibition effect from wastewater in the WWTP was negligible,even the untreated raw wastewater.However,the bioluminescence inhibition effect from wastewater which was defined as the priority biological effect,posed potential ecological risk.To decrease non-specific biological effects,especially of macromolecular dissolved organic matter,overall pollutant reduction strategy is necessary.Meanwhile,the ozonation process was used to further decrease the bioluminescence inhibition effects from the secondary effluent;≥0.34 g O 3/g DOC of ozone dose was recommended for micropollutants elimination control and ecological safety.

关键词： Micropollutants biological effect Wastewater treatment Ecological safety Ozonation

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Monitoring of biological Responses of Tumor Cells after Irradiation with ^(99m)Tc-MIBI——An In Vitro Study

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2001年第2期21卷 152-155页

作者：夏劲松吴华赵明鲜于志群 Department of Nuclear Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan

To explore the possibility to employ 99m Tc MIBI to monitor biological response of tumor cells after irradiation and to observe the relation between the radiation doses and the uptake levels of 99m Tc MIBI in tumor cells, the cells were irradiated with a single dose of 2 Gy, 10 Gy and 20 Gy respectively. The uptake of 99m Tc MIBI in each dosage group was determined before and 24, 48, 72 h after irradiation respectively. Apoptosis index , plating efficiency of tumor cells was simultaneously determined. There was a positive correlation between uptake levels of 99m Tc MIBI and AI. A negative correlation was noted between the uptake levels and PE . It is suggested that 99m Tc MIBI may be used as a tracer to monitor the change of viability state of tumor cells after being irradiated with different doses.

关键词： 99m Tc MIBI tumor cells irradiation biological effect

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biological effects of indoor sunlight in ruraldweling houses

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Journal of Environmental Sciences 1995年第4期7卷 435-442页

作者： Chen Guifu , Qiu Shicong(Wannan Medical College , Wuhu 241001 , China)

ＢｉｏｌｏｇｉｃａｌｅｆｆｅｃｔｓｏｆｉｎｄｏｏｒｓｕｎｌｉｇｈｔｉｎｒｕｒａｌｄｗｅｌｉｎｇｈｏｕｓｅｓＣｈｅｎＧｕｉｆｕ，ＱｉｕＳｈｉｃｏｎｇ（ＷａｎｎａｎＭｅｄｉｃａｌＣｏｌｌｅｇｅ，Ｗｕｈｕ２４１００１，Ｃｈ... 详细信息

ＢｉｏｌｏｇｉｃａｌｅｆｆｅｃｔｓｏｆｉｎｄｏｏｒｓｕｎｌｉｇｈｔｉｎｒｕｒａｌｄｗｅｌｉｎｇｈｏｕｓｅｓＣｈｅｎＧｕｉｆｕ，ＱｉｕＳｈｉｃｏｎｇ（ＷａｎｎａｎＭｅｄｉｃａｌＣｏｌｌｅｇｅ，Ｗｕｈｕ２４１００１，Ｃｈｉｎａ）Ｂｉｏｌｏｇｉｃａｌｅｆｆ...

关键词： biological effect deactivation of bacteria immunological effect antirachitic effect sunlight.

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Study on biological effect of La3+ on Escherichia coli by Atomic Force Microscopy

Study on Biological effect of La3+ on Escherichia coli by At...

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湖北省化学化工学会2006年年会暨循环经济专家论坛

作者： Liu Peng Liu Yi LuZhexue ZhuJuncheng Dong Jiaxin Pang Daiwen Shen Ping Qu Songsheng (Department of Chemistry, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China) (School of Life Sciences, Wuhan University, Wuhan 430072, P. R. China)

The biological effects of rare-earth metal ions on the organism have been studied using La3+ as a probe ion and Escherichia coli cell as a target organism. Atomic force microscopy (AFM) studies reveal that La3+ substantially changes the structure of the outer cell membrane responsible for the cell permeability. Significant damages of the outer cell membrane are observed using scanning electron microscopy (SEM) after the introduction of La3+. In result, the cell becomes easily attacked by lysozyme. Moreover, inductively coupled plasma-mass spectrometry (ICP-MS) measurements show considerable amount of Ca2+ and Mg2+ in the supernatant from the La3+ exposed cells. It is proposed that La3+ can replace Ca2+ from the binding sites because of their close ionic radii and similar ligand specificities. Lipopolysaccharide (LPS), which forms the outer membrane of Gram-negative bacteria, could not serve as the cellular envelope steadily after Ca2+ and Mg2+ released from their binding sites on the LPS patches.

关键词： La3+ lipopolysaccharide permeability biological effect lysozyme

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Low-frequency HIFU induced cancer immunotherapy:tempting challenges and potential opportunities

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Cancer Biology & Medicine 2019年第4期16卷 714-728页

作者： Guilian Shi Mingchuan Zhong Fuli Ye Xiaoming Zhang School of Biomedical Engineering Hubei University of Science and TechnologyXian ning 437100China Department of Radiology Mayo Clinic College of MedicineRochester 55905MNUSA

Immunotherapy is playing an increasingly important role in the treatment of tumors.Different from the traditional direct killing or excision therapies,immunotherapy depends on autologous immunity to kill tumor cells and tissues by activating or enhancing the body's immune system.Large numbers of recent studies suggest that low-frequency HIFU can not only enhance the intensity of the body's anti-cancer immune response,but also improve the efficiency of immunotherapy drug delivery to strengthen the effects of tumor immunotherapy.The focused ultrasound(FUS)destructs the tumor and simultaneously generates tumor debris and tumor-associated antigens,which enhances the immunogenicity of the tumor and stimulates the immune cells,inducing the body's immune response.Microbubbles are clinically used as a contrast.As a matter of fact,the addition of microbubbles can reinforce the destructive effect of FUS on the tumor and activate a stronger immune response.The combined application of ultrasound and microbubbles can more effectively open the blood brain barrier(BBB),which is beneficial to improving the intake of immune cells or immunotherapy drugs and exerting a positive influence in the lesion area.Currently,microbubbles and nanoparticles are commonly used as gene and drug carriers.Using ultrasound,the immune-related gene or antigen delivery itself can enhance the immune response and improve the efficacy of the immunotherapy.

关键词： Immunotherapy low-frequency HIFU biological effect immune response combination therapy

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A Study on the biological effects of Laser-induced Mutation on Fibrous Roots of Yellow Skin Onion

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Agricultural Biotechnology 2012年第4期1卷 15-16,21页

作者： Tianchun PAN Chengzuo LI Xichang College

[ Objective] This study aimed to investigate the biological effects of laser-induced mutation on fibrous roots of yellow skin onion. [ Method] Wet seeds of two yellow skin onion cultivars were irradiated by CO2 laser and He-Ne laser at three dosage levels separately. A randomized complete block design with three replications was adopted. The biological effects of laser-induced mutation on fibrous roots of Ll-generation yellow skin onion were investigated with biostatistics and physiological and biochemical methods. [Result] Significant variations in the biological effects caused by various laser treatments were observed in the length, quantity, fresh weight and activity of onion fibrous roots. Specifically, the variation in fibrous root length induced by different types of laser reached 5% significance level; significant variation was observed in fibrous roots of different onion cultivars induced by laser, while the variation among each treatment did not reach 5% sig- nifieance level ; the variation in fibrous root quantity induced by different dosage levels of laser reached 5% significance level ; laser radiation showed stimulating effect on root activity of onion. [ Conclusion] This study provided reference for laser-induced breeding of yellow skin onion.

关键词： Laser Yellow skin onion Fibrous root biological effect

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Means, Advantages and Limits of Merging Biology with Technology

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Journal of Bionic Engineering 2004年第2期1卷 121-132页

作者： O. A. Bogatyreva A.-K. Pahl. N.R. Bogatyrev J.F.V. Vincent Centre for Biomimetic and Natural Technologies Department of Mechanical Engineering the University of Bath BA2 7AY UKCentre for Biomimetic and Natural Technologies Department of Mechanical Engineering the University of Bath BA2 7AY UKCentre for Biomimetic and Natural Technologies Department of Mechanical Engineering the University of Bath BA2 7AY UKCentre for Biomimetic and Natural Technologies Department of Mechanical Engineering the University of Bath BA2 7AY UK

The natural world spent billions of years in solution-finding during evolution, which could benefit Technology. How do we put that in a nutshell? biological systems are more complex than the most complex current technology. Any given function and effect are simultaneously coordinated and linked with others at many levels of biological organisation-from cell organelle to organism, to population and ecosystem. Technology does not have tools to deal with the complexity and “goal-intendedness” of living systems. But limits for interaction exist on both sides-biological science itself is also too empirical and not mature enough to provide a solid base for correlating living with technical systems. Moving towards a synthesis, where engineers can utilize the vast amount of available biological data, we suggest using a tool called “Theory of Inventive Problem Solving” (TRIZ) and clarifying some important methodological issues, which have not previously been recognised in bionic engineering: 1) Requirement for more appropriate definitions of “system”, “effect”, “function”,“law” and “rule”. 2) Requirement for understanding or even measuring the degree of contradiction or analogy between functions in biological and artificial and/or non-living engineering system-there is no simple direct correlation between what engineers find useful and what biology does.

关键词： technology TRIZ biological effect contradiction science methodology

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