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Flexible and Stretchable Electrodes for In Vivo Electrophysiological and Electrochemical Monitoring

Chinese Journal of Chemistry 2024年第13期42卷 1523-1545页

作者： Kai-Kai Sheng Yi-Fei Lu Wen-Ting Fan Yan-Ling Liu College of Chemistry and Molecular Sciences Wuhan University WuhanHubei 430072China Core Facilty of Wuhan University WuhanHubei 430072China

In vivo monitoring of bioelectrical and biochemical signals with implanted electrodes has received great interest over the past ***,this faces huge challenges because of the severe mechanical mismatch between conventional rigid electrodes and soft biological *** recent years,the emergence of flexible and stretchable electrodes offers seamless and conformable biological-electronic interfaces and has demonstrated significant advantages for in vivo electrochemical and electrophysiological *** review first summarizes the strategies for electrode fabrication from the point of substrate and conductive ***,recent progress in electrode functionalization for improved performance is ***,the advances of flexible and stretchable electrodes in exploring bioelectrical and biochemical signals are ***,we present some challenges and perspectives ranging from electrode fabrication to application.

关键词： Flexible electrodes Conductive materials Stretchable structures Electrode functionalization In vivo monitoring Biochemical signals bioelectrical signals

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A Time-Varying Parameter Estimation Method for Physiological Models Based on Physical Information Neural Networks

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Computer Modeling in Engineering & Sciences 2023年第12期137卷 2243-2265页

作者： Jiepeng Yao Zhanjia Peng Jingjing Liu Chengxiao Fan Zhongyi Wang Lan Huang College of Information and Electrical Engineering China Agricultural UniversityBeijing100083China Key Laboratory of Agricultural Information Acquisition Technology(Beijing) Ministry of AgricultureBeijing100083China Key Laboratory of Modern Precision Agriculture System Integration Research Ministry of EducationBeijing100083China

In the establishment of differential equations,the determination of time-varying parameters is a difficult problem,especially for equations related to life ***,we propose a new framework named BioE-PINN based on a physical information neural network that successfully obtains the time-varying parameters of differential *** the proposed framework,the learnable factors and scale parameters are used to implement adaptive activation functions,and hard constraints and loss function weights are skillfully added to the neural network output to speed up the training convergence and improve the accuracy of physical information neural *** this paper,taking the electrophysiological differential equation as an example,the characteristic parameters of ion channel and pump kinetics are determined using *** results demonstrate that the numerical solution of the differential equation is calculated by the parameters predicted by BioE-PINN,the RootMean Square Error(RMSE)is between 0.01 and 0.3,and the Pearson coefficient is above 0.87,which verifies the effectiveness and accuracy of ***,realmeasuredmembrane potential data in animals and plants are employed to determine the parameters of the electrophysiological equations,with RMSE 0.02-0.2 and Pearson coefficient above *** conclusion,this framework can be applied not only for differential equation parameter determination of physiological processes but also the prediction of time-varying parameters of equations in other fields.

关键词： Physics-informed neural network differential equation bioelectrical signals inverse problems

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Development of a portable multi-channel system for plant physiological signal recording

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Information Processing in Agriculture 2016年第2期3卷 124-132页

作者： Ting Li Zi-Yang Wang Dong-Jie Zhao Lan Huang Zhong-Yi Wang College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083China Modern Precision Agriculture System Integration Research Key Laboratory of Ministry of Education Beijing 100083China Key Laboratory of Agricultural Information Acquisition Technology(Beijing) Ministry of AgricultureBeijing 100083China

bioelectrical signals can reflect physiological state of organs or tissues in plants and have a significant potential value in research of plant stress *** order to study the relationship between environment factors and electrical signals in plant,a portable multichannel physiological signal acquisition system which relevant in plant physiology research was *** parameters and electrical signals can be measured in different channels by the acquisition system simultaneously and the measurement data will be displayed in an embedded integrated touch screen which is the system processing *** system was validated to be stable and reliable after the calibration and repeated experiments of recording electrical signals in Helianthus annuus L.

关键词： bioelectrical signals Acquisition system Multi-channel Portable device

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Biomimetic Synthesized Conductive Copolymer EDOT-Pyrrole Electrodes for Electrocardiogram Recording in Humans

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Journal of Materials Science and Chemical Engineering 2021年第10期9卷 19-40页

作者： Manuel Eduardo Martínez-Cartagena Juan Bernal-Martínez Carlos Alberto Aranda-Sánchez Arnulfo Banda-Villanueva José Luis Gonzalez-Zapata Antonio Ledezma-Pérez Alfredo Aguilar-Elguezabal Jorge Romero-García Advanced Materials Department Research Center in Applied Chemistry (CIQA) Saltillo Coahula México Laboratory in Biomedicine and Nanotechnology Aguascalientes Aguascalientes México Department of Reactions Engineering Research Center in Applied Chemistry (CIQA) Saltillo Coahula México Department of Engineering and Chemistry of Materials Research Center in Advanced Materials (CIMAV) Chihuahua México

We report on electrodes fabricated with EDOT-Pyrrole copolymer through electrophoretic deposition and used for recording and sensing bio-electrical signals. We measured the electrical properties of the copolymer deposited on a stainless-steel substrate, and we performed Cyclic Voltammetry (CV) and Scanning Electron Microscopy (SEM) studies to characterize the morphological properties and copolymer distribution on the metal surface. We found that electrodes fabricated with EDOT-Pyrrole copolymer exhibit a high signal-to-noise ratio as well as an accurate and stable conductivity compared with other commonly used electroconductive polymers. Stainless-steel-coated EDOT-Pyrrole electrodes are suitable to record electrocardiograms in humans with high resolution comparable to standard silver-electrodes.

关键词： Electrocardiogram bioelectrical signals Biomimetic Conductive Polymers

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