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bioeffects of Microgravity and Hypergravity on Animals

Chinese Journal of Electrical Engineering 2023年第1期9卷 29-46页

作者： Guofeng Cheng Biao Yu Chao Song Vitalii Zablotskii Xin Zhang High Magnetic Field Laboratory of Chinese Academy of Sciences(CHMFL) HFIPSCASHefei 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefei 230036China Institute of Physics of the Czech Academy of Sciences Prague 18221Czechia International Magnetobiology Frontier Research Center Science IslandHefei 230031China

Gravity alterations in space cause significant adaptive effects on the human body,including changes to the muscular,skeletal,and vestibular systems.However,multiple factors besides gravity exist in space;therefore,it is difficult to distinguish gravity-related bioeffects from those of the other factors,including radiation.Although everything on the Earth surface is subject to gravity,gravity-induced effects are not explicitly clear.Here,different research methods that have been used in gravity alterations,including parabolic flight,diamagnetic levitation,and centrifuge,are reviewed and compared.The bioeffects that are reported to be associated with altered gravity in animals are summarized,and the potential risks of hypergravity and microgravity are discussed,with a focus on microgravity,which has been studied more extensively.It should be noted that although various microgravity and hypergravity research methods have their limitations,such as the inevitable magnetic field effects in diamagnetic levitation and short duration of parabolic flight,it is evident that ground-based clinical,animal,and cellular experiments that simulate gravity alterations have served as important and necessary complements to space research.These researches not only provide critical and fundamental biological information on the effects of gravity from biomechanics and the biophysical perspectives,but also help in developing future countermeasures for astronauts.

关键词： Gravity microgravity hypergravity bioeffects static magnetic field(SMF)

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bioeffects of Low Energy Ion-Beam Implantation and Vacuum Treatment on M_1 Arabidopsis Thaliana

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Plasma Science and Technology 2006年第2期8卷 242-246页

作者：杨根卞坡张正红任杰吴李君余增亮 Key Laboratory of Ion Beam Bioengineering Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031 China Anhui University Hefei 230031 China Anhui Agricultural University Hefei 230031 China

Vacuum treatment and ion-beam bombardment are two major processes in the low energy ion-beam implantation. To accurately study the contributions of these two major factors to the bioeffects separately, the M1 generation variation of Arabidopsis thaliana with ion-beam implantation and vacuum treatment were compared through a series of key plant development parameters including morphological observation, biochemical assay and RAPD （random amplified polymorphic DNA） analysis. The results showed that ion-beam implantation had obvious effect on almost all of these parameters, and the vacuum treatment had some impacts on several morphological parameters such as the bolting time and the length of the primary stem. Taking the results together, the indication is that vacuum treatment has some slight contributions to the bioeffects of ion-beam implantation while ion-beam bombardment itself is the major creator of the bioeffects.

关键词： bioeffects ion-beam vacuum Arabidopsis thaliana

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Metabolic fate of tea polyphenols and their crosstalk with gut microbiota

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Food Science and Human Wellness 2022年第3期11卷 455-466页

作者： Meiyan Wang Jianying Li Ting Hu Hui Zhao Tianjin Key Laboratory of Food and Biotechnology School of Biotechnology and Food ScienceTianjin University of CommerceTianjin 300134China Hubei Key Laboratory for EFGIR Huanggang Normal UniversityHuanggang 438000China

Tea represents an abundant source of naturally occurring polyphenols.Tea polyphenols(TPs)have received growing attentions for its wide consumption in the world,and more importantly its pleiotropic bioeffects for human health.After ingestion,TPs may undergo absorption and phase II reaction in the small intestine,and most undigested proportion would be submitted to the colon to interact with gut microbiota.Interactions between gut microbiota and TPs are bidirectional,including not only bacteria-mediated TPs metabolism,e.g.,removal of gallic acid moiety and ring fission to release phenolic acid catabolites,but also TPs-based modification of bacterial profiles.Crosstalk between TPs and gut microbes may benefit for gut barrier function,for example,improvement of the intestinal permeability to alleviate inflammation.Moreover,by reshaping microbial composition and associated metabolites,TPs may exert a systemic protection on host metabolism,which contributes to improve certain chronic metabolic disorders.Given that,further understanding of the metabolic fate of TPs and interplay with gut microbiota as well as potential health-promoting effects are of great significance to development and application of tea and their polyphenolic components in the future as dietary supplements and/or functional ingredients in medical foods.

关键词： Tea polyphenols Metabolism Gut microbiota bioeffects

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Experimental study and mechanism analysis on bioeffects by nanosecond electromagnetic pulses

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Science China(Life Sciences) 1997年第3期40卷 301-304页

作者：王保义杨杰斌郭庆功徐润民刘长军张弘邹方东王子淑 Department of Radio-electronics Sichuan Union University Chengdu 610064 China Biology Department Sichuan Union University Chengdu 610064 China

The athermal bioeffects caused by nanosecond electromagnetic pulses with body cells was studied by using a broad band transverse EM-wave cell (BTEM CELL). The experimental system and preliminary mechanism analysis wer... 详细信息

关键词： nanosecond electromagnetic pulses athermal bioeffects mechanism analysis BTEM CELL.

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High intensity focused ultrasound in clinical tumor ablation

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World Journal of Clinical Oncology 2011年第1期2卷 8-27页

作者： Yu-Feng Zhou Division of Engineering Mechanics School of Mechanical and Aerospace EngineeringNanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Recent advances in high intensity focused ultrasound(HIFU),which was developed in the 1940s as a viable thermal tissue ablation approach,have increased its popularity.In clinics,HIFU has been applied to treat a variety of solid malignant tumors in a well-defined volume,including the pancreas,liver,prostate,breast,uterine fibroids,and soft-tissue sarcomas.In comparison to conventional tumor/cancer treatment modalities,such as open surgery,radio-and chemo-therapy,HIFU has the advantages of non-invasion,non-ionization,and fewer complications after treatment.Over 100 000 cases have been treated throughout the world with great success.The fundamental principles of HIFU ablation are coagulative thermal necrosis due to the absorption of ultrasound energy during transmission in tissue and the induced cavitation damage.This paper reviews the clinical outcomes of HIFU ablation for applicable cancers,and then summarizes the recommendations for a satisfactory HIFU treatment according to clinical experience.In addition,the current challenges in HIFU for engineers and physicians are also included.More recent horizons have broadened the application of HIFU in tumor treatment,such as HIFU-mediated drug delivery,vessel occlusion,and soft tissue erosion(“histotripsy”).In summary,HIFU is likely to play a significant role in the future oncology practice.

关键词： High intensity focused ultrasound Thermal ablation Image-guided therapy Cancer Bubble cavitation bioeffects

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