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A study on interaspecific biodiversity of eight groups of silkworm （Bombyx mori） by biochemical markers

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Insect Science 2005年第2期12卷 87-94页

作者： KAYVANETEBARI S.Z.MIRHOSEINI L.MATINDOOST Department of Sericulture Faculty of Natural ResourcesUniversity of GuilanSomeheSaraIran

The recognition of biodiversity in different races and lines of silkworm (Bombyx mori) is very useful for breeding programs and production of high efficiency hybrids. In this study eight groups of silkworm were selected including 103, 107, Xihang 1 and 2 of Japanese origin and 104, 110, Koming 1 and 2 of Chinese origin. The activity levels of three enzymes including alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase in haemolymph of fifth instar larva were measured. Moreover, the quantitative amount of total protein, cholesterol and glucose of haemolymph was *** data reveal that the activity level of measured macromolecules except for alkaline phosphatase were significantly different in all the groups. Hierarchical agglomerative clustering under UPGMA model separated line 104 from other groups. Two groups of Koming 1 and Xihang 1 had the most intergroup similarities.

关键词： silkworm biochemical markers biodiversity hierarchical agglomerativeclustering

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International Journal of Otolaryngology and Head & Neck Surgery 2021年第4期10卷 320-335页

作者： Joaquim Castro Silva Patricia Tavares Rita Ferreira Lucio Lara Santos Eurico Monteiro Instituto Portuguê s de Oncologia do Porto Francisco Gentil Porto Portugal LAQV Department of Chemistry University of Aveiro Aveiro Portugal

Cachexia is a multifactorial syndrome related to unintentional weight loss and to loss of muscle and fat mass. In head and neck cancer (HNC) its incidence is important and not only related to a deficient intake of food due to the impact of the disease in the vital functions. A complex disturbance in the normal metabolism of the patient promotes a persistent inflammatory state and a shifting in the metabolism balance toward a catabolic predominance affecting primarily the skeletal muscle. This leads to severe impairment of the functional, emotional and social status and quality of life of the patients that will compromise response to treatment and the disease prognosis. Understanding this deleterious syndrome and mainly identifying it in early stages of the disease is of a major importance in achieving better outcomes to head and neck cancer patients. This study pretends to identify clinical aspects related to cachexia in HNC in a clinical perspective for application on the routine clinical practice. In our study, 30 HNC patients were enrolled and evaluated in terms of nutritional values (actual and loss of weight in the past 6 months, body mass index (BMI), nutritional risk index (NRI), malnutrition universal screening tool), serum biochemical markers (albumin, total proteins, cholesterol, triglycerides, urea, C-reactive protein (CRP), interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α) and myostatin) and health related quality of life (HRQoL) evaluation (using European Organisation for the Research and Treatment of Cancer (EORTC) quality of life questionnaires (QLQ): EORTC QLQ-C30 and EORTC QLQ-HN43). A minimum follow-up of 48 months was considered for all patients. Our results showed that NRI is a good and sensitive index to identify cachexia. This index uses two parameters, one constitutional (loss of weight) and one biochemical (level of serum albumin). According to this criterion, 16 patients were assigned to the No-cachexia group and 14 patients to the Cach

关键词： Cachexia Head Neck Cancer Quality of Life biochemical markers Malnutrition

Correlation of Abortus Imminence Cases in the First Trimester with biochemical markers

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Open Journal of Obstetrics and Gynecology 2023年第2期13卷 207-213页

作者： Küçükyurt Ayça Kubat Basat Dilara Bingöl Bugra Berkan Artuğ Cansızlar Gülnihal İlhan Gülşah Istanbul Research and Education Hospital Obstetrics and Gynecology Istanbul Türkiye Bossan International Hospital Istanbul Türkiye

Objective: In this study, we compared the biochemical markers of imminent abortion, missed abortion, and healthy pregnant women in the first trimester to see if there were any differences. Materials and Methods: The study method is prospective. Pregnant women who applied to the obstetrics clinic of Istanbul Training and Research Hospital between 01.04.22 and 31.10.22 were diagnosed with abortion imminens or missed abortion between 6 weeks and 12 weeks or had normal pregnancy follow-up, had no chronic diseases, and did not take magnesium and calcium supplements were included in the study. 20 pregnant women with missed abortion, 20 pregnant women with abortion imminens diagnosis and 20 normal pregnant women who met the criteria were included in the study. Magnesium (Mg), calcium (Ca), copper (Cu), zinc (Zn) and hemogram (CBC) levels were checked in pregnant women included in the study. Results: The Mg, Cu, Zn, and CBC values of the study participants’ women did not differ in a statistically significant way. When compared to pregnant women who had a normal pregnancy process, the difference in Ca value was found to be statistically substantially smaller in pregnant women who were diagnosed with abortion imminens and missed abortion. The findings of our study suggest that serum Ca levels be measured prior to conception or at the initial visit. Conclusion: Serum Ca levels were found to be significantly lower in the missed abortion group than in the abortus imminens and normal pregnant groups in our study (p 0.05).

关键词： Abortion biochemical markers Calcium Copper Magnesium Missed Abor-tion Spontaneous Abortion Zinc

可穿戴电化学传感器在生化标志物原位检测领域的最新研究进展（英文）

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Science China Materials 2025年第03期68卷 755-774页

作者：焦艳丽于欣格 Department of Biomedical Engineering City University of Hong Kong Centre for Cerebro-Cardiovascular Health Engineering(COCHE)

近年来,可穿戴电化学传感器在生化分析领域得到了广泛应用.这些传感器通过将柔性电极和敏感识别元件集成于柔性衬底上,实现了对生物流体中目标生化分子的非侵入性、原位、实时及连续监测,并保持了高选择性和灵敏度.本文综述了近年来用... 详细信息

近年来,可穿戴电化学传感器在生化分析领域得到了广泛应用.这些传感器通过将柔性电极和敏感识别元件集成于柔性衬底上,实现了对生物流体中目标生化分子的非侵入性、原位、实时及连续监测,并保持了高选择性和灵敏度.本文综述了近年来用于生化标志物检测的可穿戴电化学传感器的核心元件选择原则及其最新进展.首先,我们概述了设计用于检测生物流体中生物标志物的可穿戴传感器的基本考虑因素,包括采样技术、材料选择、设计参数、识别元素、传感策略、功率需求、数据处理及传感器集成.生物技术和材料科学的进步显著提升了识别元件的效率,从而在复杂基质中实现了对目标成分的选择性和灵敏检测.此外,纳米材料与导电聚合物的结合显著增强了柔性电子器件的传感能力.随后,我们探讨了可穿戴电化学传感器对生化标志物进行原位检测的最新进展.这些传感器利用先进材料、优化机械结构及采用多种传导机制制备来实现对不同生物标志物的筛选和检测.这些技术创新不仅提高了用户舒适度,还在灵敏度、可靠性和监测能力方面取得了显著进步.最后,我们讨论了当前面临的挑战及未来前景,旨在实现临床导向的可穿戴电化学传感器,以支持疾病监测和个性化医疗.

关键词： wearable sensors electrochemical biochemical markers in situ non-invasive

Urine products of bone breakdown as markers of bone resorption and clinical usefulness of urinary hydroxyproline:an overview

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Chinese Medical Journal 2004年第2期17卷 291-295页

作者： Baris Simsek zgülKaracaer inci Karaca Department of Oral and Maxillofacial Surgery Faculty of Dentistry University of Gazi Emek Ankara TurkeyDepartment of Oral and Maxillofacial Surgery Faculty of Dentistry University of Gazi Emek Ankara TurkeyDepartment of Prosthodontics Faculty of Dentistry University of Gazi Emek Ankara Turkey

Purpose The purpose of this study is to review the urine products of bone breakdown as markers of bone resorption and usefulness of urinary hydroxyproline.Data Related researches published in 1985 -2000 were systematically reviewed.Results Bone markers could be used for early diagnosis of bone metabolic diseases. biochemical markers of bone resorption that reflect osteoclast activity and/or collagen degradation provide a new and potentially important clinical tool for the assessment and monitoring of bone metabolism. Assessment of bone resorption can be achieved with measurement of urinary hydroxylysine glycosides, urinary excretion of the collagen pyridinium cross-links, urinary excretion of type I collagen telopeptide breakdown products (cross-linked telopeptides) and urinary hydroxyproline.Conclusion Urinary hydroxyproline has been in use as a marker of bone resorption, but it lacks sensitivity and specificity. It is a modified aminoacid that is a metabolic product of collagen breakdown. Hydroxyproline may be released either free or with fragments of the collagen molecule attached during bone resorption, and it is also liberated by the breakdown of complement and nonskeletal collagen.

关键词： bone resorption marker biochemical markers hydroxyproline collagen breakdown hydroxylysine glycosides pyrolidine deoxypyrolidine N-tebpeptides C-telopeptides

Genetic Analysis and Fine Mapping of a Novel Semidominant Dwarfing Gene LB4D in Rice

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Journal of Integrative Plant Biology 2011年第4期53卷 312-323页

作者： Fei Liang Xiaoyun Xin Zejun Hu Jiandi Xu Gang Wei Xiaoyin Qian Jinshui Yang Haohua He Xiaojin Luo State Key Laboratory of Genetic Engineering Instituteof Genetics School of Life Sciences Fudan University Shanghai 200433 China Key Laboratory of Crop Physiology Ecology and Genetic Breeding Ministry of Education Jiangxi Agricultural University Nanchang 330045 China Institute of Rice Research Shandong Academy of Agricultural Sciences Jining 272100 China

A dwarf mutant,designated LB4D,was obtained among the progeny of backcrosses to a wild rice introgression *** analysis of LB4D indicated that the dwarf phenotype was controlled by a single semidominant dwarfing gene,which was named *** mutants were categorized as dn-type dwarf mutants according to the pattern of internode *** addition,gibberellin（GA） response tests showed that LB4D plants were neither deficient nor insensitive to *** study found that tiller formation by LB4D plants was decreased by 40%compared with the wild type,in contrast to other dominant dwarf mutants that have been identified,indicating that a different dwarfing mechanism might be involved in the LB4D dominant *** reduction of plant height in F1 plants ranged from 27.9%to 38.1%in different genetic backgrounds,showing that LB4D exerted a stronger dominant dwarfing effect. Using large F2 and F3 populations derived from a cross between heterozygous LB4D and the japonica cultivar Nipponbare,the LB4D gene was localized to a 46 kb region between the markers Indel 4 and Indel G on the short arm of chromosome 11,and four predicted genes were identified as candidates in the target region.

关键词： DWARFISM in plants -- Genetic aspects PLANT gene mapping PLANT mutation breeding PLANTS -- Population biology biochemical markers BRASSINOSTEROIDS GIBBERELLINS RICE GENETICS

Can Biomarkers Help the Early Diagnosis of Parkinson's Disease?

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Neuroscience Bulletin 2017年第5期33卷 535-542页

作者： Weidong Le Jie Dong Song Li Amos D. Korczyn Liaoning Provincial Center for Clinical Research on Neurological Diseases The First Affiliated HospitalDalianMedical UniversityDalian 116021China Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases The First Affiliated HospitalDalian Medical UniversityDalian 116021China Collaborative Innovation Center for Brain Science The First Affiliated HospitalDalian Medical UniversityDalian 116021China Department of Neurology Sackler School of MedicineTel Aviv University69978 Ramat-AvivIsrael

Parkinson＇s disease （PD） is a complex neurode- generative disease with progressive loss of dopamine neurons. PD patients usually manifest a series of motor and non-motor symptoms. In order to provide better early diagnosis and subsequent disease-modifying therapies for PD patients, there is an urgent need to identify sensitive and specific biomarkers. Biomarkers can be divided into four categories： clinical, imaging, biochemical, and genetic. Ideal biomarkers not only improve our under- standing of PD pathogenesis and progression, but also provide benefits for early risk evaluation and clinical diagnosis of PD. Although many efforts have been made and several biomarkers have been extensively investigated, few if any have been found useful for early diagnosis. Here, we summarize recent developments in the discovered biomarkers of PD and discuss their merits and limitations for the early diagnosis of PD.

关键词： Parkinson's disease· Biomarker Early diag-nosis - Molecular imaging biochemical markers

Development and validation of a novel non-invasive test for diagnosing nonalcoholic fatty liver disease in Chinese children

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World Journal of Pediatrics 2024年第4期20卷 413-421页

作者： Zhe-Wen Qin Qian-Nan Ren Hong-Xi Zhang Ya-Ru Liu Ke Huang Wei Wu Guan-Ping Dong Yan Ni Jun-Fen Fu Division of Endocrinology National Clinical Research Center for Child HealthNational Children’s Regional Medical CenterThe Children’s HospitalDepartment of EndocrinologyNational Clinical Research Center for Child HealthNational Children’s Regional Medical CenterThe Children’s HospitalZhejiang University School of MedicineHangzhou310052China

With the exploding prevalence of obesity,many children are at risk of developing nonalcoholic fatty liver *** anthropometric and laboratory parameters,our study aimed to develop a model to quantitatively evaluate liver fat content(LFC)in children with *** A well-characterized cohort of 181 children between 5 and 16 years of age were recruited to the study in the Endocrinology Department as the derivation *** external validation cohort comprised 77 *** assessment of liver fat content was performed using proton magnetic resonance *** and laboratory metrics were measured in all subjects.B-ultrasound examination was carried out in the external validation *** Kruskal-Wallis test,Spearman bivariate correlation analyses,univariable linear regressions and multivariable linear regression were used to build the optimal predictive *** The model was based on indicators including alanine aminotransferase,homeostasis model assessment of insulin resistance,triglycerides,waist circumference and Tanner *** adjusted R^(2)of the model was 0.589,which presented high sensitivity and specificity both in internal[sensitivity of 0.824,specificity of 0.900,area under curve(AUC)of 0.900 with a 95%confidence interval:0.783–1.000]and external validation(sensitivity of 0.918 and specificity of 0.821,AUC of 0.901 with a 95%confidence interval:0.818–0.984).Conclusions Our model based on five clinical indicators was simple,non-invasive,and inexpensive;it had high sensitivity and specificity in predicting LFC in ***,it may be useful for identifying children with obesity who are at risk for developing nonalcoholic fatty liver disease.

关键词： biochemical markers Children Magnetic resonance spectroscopy Nonalcoholic fatty liver disease Pediatric obesity

Novel hepatocellular carcinoma molecules with prognostic and therapeutic potentials

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World Journal of Gastroenterology 2014年第5期20卷 1268-1288页

作者： Bruna Scaggiante Maryam Kazemi Gabriele Pozzato Barbara Dapas Rosella Farra Mario Grassi Fabrizio Zanconati Gabriele Grassi Department of Life Sciences University Hospital of Cattinara Department of Medical Surgery and Health Sciences University of Trieste Cattinara Hospital Department of Engineering and Architecture University of Trieste

Hepatocellular carcinoma(HCC), the predominant form of primary liver cancer, is the sixth most common cancer worldwide and the third leading cause of cancerrelated death. The difficulty to diagnose early cancer stages, the aggressive behaviors of HCC, and the poor effectiveness of therapeutic treatments, represent the reasons for the quite similar deaths per year and incidence number. Considering the fact that the diagnosis of HCC typically occurs in the advanced stages of the disease when the therapeutic options have only modest efficacy, the possibility to identify early diagnostic markers could be of significant benefit. So far, a large number of biomarkers have been associated to HCC progression and aggressiveness, but many of them turned out not to be of practical utility. This is the reason why active investigations are ongoing in this field. Given the huge amount of published works aimed at the identification of HCC biomarkers, in this review we mainly focused on the data published in the last year, with particular attention to the role of(1) molecular and biochemical cellular markers;(2) micro-interfering RNAs;(3) epigenetic variations; and(4) tumor stroma. It is worth mentioning that a significant number of the HCC markers described in the present review may be utilized also as targets for novel therapeutic approaches, indicating the tight relation between diagnosis and therapy. In conclusion, we believe that integrated researches among the different lines of investigation indicated above should represent the winning strategies to identify effective HCC markers and therapeutic targets.

关键词： Hepatocellular carcinoma biochemical markers Micro-interfering RNA Epigenetic variations Tumor stroma Angiogenic factors