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Effect of Synthesis Technique and Carbonate Content on the Crystallinity and Morphology of Carbonated Hydroxyapatite

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Journal of Materials Science & Technology 2013年第8期29卷 761-764页

作者： Chia Ching Kee Hanafi Ismail Ahmad Fauzi Mohd Noor School of Materials and Mineral Resources Engineering Engineering CampusUniversiti Sains Malaysia14300 Nibong TebalPenangMalaysia

The syntheses of nanosized carbonated hydroxyapatite （CHA） were performed by comparing dropwise and direct pouring of acetone solution of Ca（NO3）2·4H2O into mixture of （NH4）2HPO4 and NH4HCO3 at room temperature controlled at pH 11. Direct pouring method was later applied to study the increment of carbonate content in syntheses. The as-synthesized powders were characterized by various characterization techniques. The crystallographic results of the produced powders were obtained from X-ray diffraction analysis, whilst the carbonate content in the produced powders was determined by the CHNS/O elemental analyzer. Fourier transform infrared analysis confirmed that the CHA powders formed were B-type. Field emission scanning electron microscopy revealed that the powders were highly agglomerated in nanosized range and hence energy filtered transmission electron microscopy was employed to show elongated particles which decreased with increasing carbonate content.

关键词： bioceramic Carbonated hydroxyapatite Dropwise Direct pouring

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A biomaterial-based therapy for lower limb ischemia using Sr/Si bioactive hydrogel that inhibits skeletal muscle necrosis and enhances angiogenesis

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Bioactive Materials 2023年第8期26卷 264-278页

作者： Ye Yuan Zhaowenbin Zhang Fandi Mo Chen Yang Yiren Jiao Enci Wang Yuchong Zhang Peng Lin Chengkai Hu Weiguo Fu Jiang Chang Lixin Wang Department of Vascular Surgery Zhongshan HospitalFudan University180 Fenglin RoadShanghai200032China Department of Vascular Surgery Zhongshan Xiamen HospitalFudan University668 JinhuRoadXiamen361015China Joint Centre of Translational Medicine The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou325000China Shanghai Institute of Ceramics Chinese Academy of Sciences1295 Dingxi RoadShanghai200050China

Muscle necrosis and angiogenesis are two major challenges in the treatment of lower-limb ischemic *** this study,a triple-functional Sr/Si-containing bioceramic/alginate composite hydrogel with simultaneous bioactivity in enhancing angiogenesis,regulating inflammation,and inhibiting muscle necrosis was designed to treat lower-limb ischemic *** particular,sodium alginate,calcium silicate and strontium carbonate were used to prepare injectable hydrogels,which was gelled within 10 *** importantly,this composite hydrogel sustainedly releases bioactive Sr^(2+)and SiO_(3)^(2-) ions within 28 *** biological activity of the bioactive ions released from the hydrogels was verified on HUVECs,SMCs,C2C12 and Raw 264.7 cells in vitro,and the therapeutic effect of the hydrogel was confirmed using C57BL/6 mouse model of femoral artery ligation in *** results showed that the composite hydrogel stimulated angiogenesis,developed new collateral capillaries,and re-established the blood *** addition,the bioactive hydrogel directly promoted the expression of muscle-regulating factors(MyoG and MyoD)to protect skeletal muscle from necrosis,inhibited M1 polarization,and promoted M2 polarization of macrophages to reduce inflammation,thereby protecting skeletal muscle cells and indirectly promoting *** results indicate that these bioceramic/alginate composite bioactive hydrogels are effective biomaterials for treating hindlimb ischemia and suggest that biomaterial-based approaches may have remarkable potential in treating ischemic diseases.

关键词： Hindlimb ischemic diseases Strontium carbonate and calcium silicate bioceramic Bioactive hydrogel Muscle necrosis Angiogenesis

Microstructural features of flower like Fe brushite

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Progress in Natural Science:Materials International 2017年第4期27卷 520-526页

作者： S.I.El-dek S.F.Mansour M.A.Ahmed M.K.Ahmed Materials Science and Nanotechnology Department Faculty of Post Graduate Studies for Advanced Science Beni-Suef University Physics Department Faculty of ScienceZagazig University Materials Science Lab(1) Physics Department Faculty of Science Cairo University

The iron doped brushite(Fe-DCPD) nano particles were synthesized via co-precipitation method with Fe concentrations(0 ≤x≤ 1) in steps 0.2. The influence of iron concentration on the crystallinity, particle shape,morphology, optical, magnetic and electrical properties was investigated. The results showed that iron doping content is the crucial factor in the variation of physical properties. The particle shape changed from spheres at x=0.2 to be fiber network at x = 0.8. The saturation magnetization(Ms) increased from 0.4(emu/g) at x = 0.2 to 1.6(emu/g) at x = 0.8 which is considered more than four times with a considerable decrease of coercive field.

关键词： bioceramic Calcium phosphate Brushite Fe brushite Magnetic hydroxyapatite

3D printing of bone tissue engineering scaffolds

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Bioactive Materials 2020年第1期5卷 82-91页

作者： Chong Wang Wei Huang Yu Zhou Libing He Zhi He Ziling Chen Xiao He Shuo Tian Jiaming Liao Bingheng Lu Yen Wei Min Wang School of Mechanical Engineering Dongguan University of TechnologySongshan LakeDongguanGuangdongPR China Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiPR China Department of Mechanical Engineering The University of Hong KongPokfulam RoadHong KongHong Kong SARPR China Department of Chemistry Tsinghua UniversityBeijingPR China Institute of Biomedical and health engineering Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdongPR China

Tissue engineering is promising in realizing successful treatments of human body tissue loss that current methods cannot treat well or achieve satisfactory clinical *** scaffold-based bone tissue engineering,a high performance scaffold underpins the success of a bone tissue engineering strategy and a major direction in the field is to produce bone tissue engineering scaffolds with desirable shape,structural,physical,chemical and biological features for enhanced biological performance and for regenerating complex bone ***-dimensional(3D)printing can produce customized scaffolds that are highly desirable for bone tissue *** enormous interest in 3D printing and 3D printed objects by the science,engineering and medical communities has led to various developments of the 3D printing technology and wide investigations of 3D printed products in many industries,including biomedical engineering,over the past *** is now possible to create novel bone tissue engineering scaffolds with customized shape,architecture,favorable macro-micro structure,wettability,mechanical strength and cellular *** article provides a concise review of recent advances in the R&D of 3D printing of bone tissue engineering *** also presents our philosophy and research in the designing and fabrication of bone tissue engineering scaffolds through 3D printing.

关键词： 3D printing Bone tissue engineering Scaffold bioceramic Polyester Hydrogel Biomolecule Controlled release

Calcium silicate accelerates cutaneous wound healing with enhanced re-epithelialization through EGF/EGFR/ERK-mediated promotion of epidermal stem cell functions

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Burns & Trauma 2021年第1期9卷 184-195页

作者： Bingmin Li Haowen Tang Xiaowei Bian Kui Ma Jiang Chang Xiaobing Fu Cuiping Zhang Research Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Division and Fourth Medical Center of Chinese PLA General Hospital 100048BeijingChina Research Unit of Trauma Care Tissue Repair and RegenerationChinese Academy of Medical Sciences100048BeijingChina Department of Dermatology Fourth Medical Center of Chinese PLA General Hospital100048BeijingChina Faculty of Hepato-Biliary-Pancreatic Surgery Chinese PLA General Hospital100853BeijingChina Shanghai Institute of Ceramics Chinese Academy of Sciences200050ShanghaiChina

Background:Human epidermal stem cells(hESCs)play an important role in re-epithelialization and thereby in facilitating wound healing,while an effective way to activate hESCs remains to be *** silicate(CS)is a form of bioceramic that can alter cell behavior and promote tissue ***,we have observed the effect of CS on hESCs and investigated its possible ***:Using a mouse full-thickness skin excision model,we explored the therapeutic effect of CS on wound healing and *** vitro,hESCs were cultured with diluted CS ion extracts(CSIEs),and the proliferation,migration ability and stemness of hESCs were *** effects of CS on the epidermal growth factor(EGF),epidermal growth factor receptor(EGFR)and extracellular signal-related kinase(ERK)signaling pathway were also ***:In vivo,CS accelerated wound healing and *** demonstrated that CS upregulated cytokeratin 19 and integrinβ1 expression,indicating that CS improved hESCs *** vitro studies confirmed that CS improved the biological function of *** the possible mechanism could be due to the activation of the EGF/EGFR/ERK signaling ***:CS can promote re-epithelialization and improve the biological functions of hESCs via activating the EGF/EGFR/ERK signaling pathway.

关键词： bioceramic calcium silicate epidermal stem cells re-epithelialization wounds

Experimental study of the effect of platelet-rich plasma on osteogenesis in rabbit

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Chinese Medical Journal 2004年第12期17卷 1853-1855页

作者：张长青袁霆曾炳芳 Department of Orthopaedics Shanghai Sixth People’s Hospital Shanghai Jiaotong University Shanghai 200233 China

Platelet-rich plasma (PRP) is produced from a patient's own blood by centrifugation, and PRP contains several kinds of growth factors in high concentration such as platelet derived growth factor (PDGF), transforming growth factor-β (TGF-β), vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), epidermal growth factor (EGF), and so on.1 These growth factors have proved to offer an improved quality and speed of healing for both hard and soft tissue.2 In this study, PRP compounded with porous bioceramic was used to repair a bone defect in rabbit radius. The radiographic and histological qualitative and quantitative observations were performed to evaluate osteogenesis.

关键词： platelet rich plasma bone defect osteogenesis bioceramic

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Predicting the Mechanical Properties of BHA-Li2O Composites Using Artificial Neural Networks

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Journal of Biomaterials and Nanobiotechnology 2011年第1期2卷 98-101页

作者： Hasan Huseyin Celik Oguzhan Gunduz Nazmi Ekren Zeeshan Ahmad Faik Nuzhet Oktar 不详

In this study the mechanical properties of bovine hydroxyapatite (BHA)-Li2O composites are predicted using artificial neural networks (ANN) and then compared with obtained experimental values. BHA was mixed with lithium carbonate (Li2CO3) and sintered at various temperatures between 900-1300°C. Selected experimental values obtained for the compression strength, microhardness and density were used to define and train the ANN system. Intermediate data values not used to train the ANN model were then used to compare and determine the reliability of the ANN system. The results demonstrate the viable potential in using the ANN approach in predicting mechanical properties even with limited data sets.

关键词： Artificial Neural Network Hydroxyapatite Li2O Composites bioceramic

Bioactivity analysis of the Ta（Ⅴ） doped SiO2–Ca O–Na2O–P2O5 ceramics prepared by solid state sintering method

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Progress in Natural Science:Materials International 2016年第1期 41-48页

作者： Rehana Zia Madeeha Riaz Nida ul nasir Farhat Saleemi Zora Kayani Safia Anjum Farooq Bashir Tousif Hussain Department of Physics Lahore College for Women University Government College for Women University CASP Government College

The main objective of the study was to control the degradation rate of material at a higher degradation rate improving the chemical stability of the material. Ta is known to have good chemical resistance, biocompatibility and show no adverse biological response. In the present study, Si O2–Na2O–Ca O–P2O5bioceramics with different Ta2O5contents was prepared by solid state sintering method at 1000 °C. The as-sintered ceramics were subjected to immersion studies in stimulated body fluid（SBF） for 21 days under static condition and characterized by XRD, FTIR, SEM, and AAS. The findings of the research indicate that the addition of Ta2O5controlled degradability, and all samples showed sufficient bioactivity.

关键词： Crystallization Bioactivity Ta2O5 Degradation rate bioceramic