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bioceramic-mediated chondrocyte hypertrophy promotes calcified cartilage formation for rabbit osteochondral defect repair

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Bioactive Materials 2024年第10期40卷 306-317页

作者： Rachel H.Koh Junhee Kim Jeong-Uk Kim Seunghyun L.Kim Arun Kumar Rajendran Seunghun SLee Heesoo Lee Joo Hyun Kim Ji Hoon Jeong Yongsung Hwang Jong Woo Bae Nathaniel S.Hwang School of Chemical and Biological Engineering Institute of Chemical ProcessesSeoul National UniversitySeoul08826South Korea Interdisciplinary Program in Bioengineering Seoul National UniversitySeoul08826South Korea Department of Biomedical Engineering Dongguk UniversitySeoul10326South Korea Soonchunhyang Institute of Medi-bio Science(SIMS) Soonchunhyang UniversityCheonan31151South Korea Department of Integrated Biomedical Science Soonchunhyang UniversityAsan31538South Korea Department of Orthopaedic Surgery Konkuk University Chungju HospitalKonkuk University School of MedicineChungju27376South Korea BioMAX Institute Seoul National UniversitySeoul08826South Korea

Osteochondral tissue is a highly specialized and complex tissue composed of articular cartilage and subchondral bone that are separated by a calcified cartilage *** or gradient scaffolds,often in conjunction with stem cells and growth factors,have been developed to mimic the respective layers for osteochondral defect *** this study,we designed a hyaline cartilage-hypertrophic cartilage bilayer graft(RGD/RGDW)with ***,we demonstrated that RGD peptide-modified chondroitin sulfate cryogel(RGD group)is chondro-conductive and capable of hyaline cartilage ***,we incorporated whitlockite(WH),a Mg2+-containing calcium phosphate,into RGD cryogel(RGDW group)to induce chondrocyte hypertrophy and form collagen X-rich hypertrophic *** is the first study to use WH to produce hypertrophic ***-laden RGDW cryogel exhibited significantly upregulated expression of hypertrophy markers in vitro and formed ectopic hypertrophic cartilage in vivo,which mineralized into calcified cartilage in bone ***,RGD cryogel and RGDW cryogel were combined into bilayer(RGD/RGDW group)and implanted into rabbit osteochondral defect,where RGD layer supports hyaline cartilage regeneration and bioceramic-containing RGDW layer promotes calcified cartilage *** the RGD group(monolayer)formed hyaline-like neotissue that extends into the subchondral bone,the RGD/RGDW group(bilayer)regenerated hyaline cartilage tissue confined to its respective layer and promoted osseointegration for integrative defect repair.

关键词： bioceramic Whitlockite Bilayer scaffold Chondrocyte hypertrophy Osteochondral defect repair

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Characteristics of a multi-component MgO-based bioceramic coating synthesized in-situ by plasma electrolytic oxidation

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Journal of Magnesium and Alloys 2021年第5期9卷 1611-1625页

作者： Nasrinsadat Azarian Seyed Mohammad Mousavi Khoei Department of Mining and Metallurgical Engineering Amirkabir University of Technology(Tehran Polytechnic)P.O.Box 15875-4413TehranIran

Plasma electrolytic oxidation(PEO)has held great potential for the advancement of biodegradable implants,as it helps in developing porous bioceramic coatings on the surface of magnesium *** this research work,MgO-based bioceramic coatings containing the Si,P,Ca,Na,and F elements have been successfully fabricated on an AZ31 magnesium alloy plate utilizing the PEO *** characteristic current-voltage behavior of the samples during the process was surveyed in an electrolyte containing Ca(H_(2)PO_(4))_(2),Na_(2)SiO_(3)·9H_(2)O,Na_(3)PO_(4)·12H_(2)O,NaF,and KOH with a pH of 12.5 and electrical conductivity of 20 mS/cm^(-1).The results revealed that applying a voltage of 350-400 V(that is 50-100 V higher than the breakdown limit)could greatly facilitate the synthesis of a PEO ceramic coating with fewer defects and more uniform *** resulting coating was a compositionally graded bioceramic layer with a thickness in the range of 3.5±0.4 to 6.0±0.7µm,comprising the above-mentioned elements as promising bioactive *** synthesized ceramic features were investigated in terms of the elemental distribution of components through the thickness,which indicated a gradual rise in the Si and P contents and,conversely,a decline in the F content towards the outer *** growth mechanism of the PEO coating has been discussed accordingly.

关键词： Az31 magnesium alloy Plasma electrolytic oxidation bioceramic Coating MgO-based ceramic

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Valorization of a Good bioceramic from Moroccan Waste Fish Bone by a Heat Treatment Method

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Journal of Renewable Materials 2019年第1期7卷 1-7页

作者： Kaoutar Kara Fatiha Ouanji El Mostapha LOTFI Mohammed El Mahi Mohamed Kacimi Laboratory of Spectroscopy Molecular ModelingMaterialsNanomaterialsWater and EnvironmentEnvironmental Materials TeamENSETMohammed V UniversityRabatMorocco Laboratory of Nanomaterial Nanotechnology and EnvironmentPhysico-chemical of Material and Catalysis(URAC26)Faculty of SciencesUniversity of Mohammed VRabat.Morocco

A tricalcium phosphate(TCP)material was produced from sardine and mackerel waste using a heat treatment method after a Soxhlet extraction to obtain the non-soluble portion of fish *** bones were annealed at temperatures between 400℃ and 1200℃.The thermal analysis(TG-DTA)was carried out to investigate the thermal stability of TCP and to confirm the removal of organic matter from the raw *** calcined bones were characterized by Fourier transform infrared spectroscopy(FT-IR),X-ray diffraction(XRD),and field emission scanning electron microscopy(FESEM).The calcium to phosphorous weight ratio was determined by ***-IR and XRD confirmed the similarities to syntheticβ-TCP(JCPDS-09-169),FE-SEM results revealed the formation of nanostructured *** results suggest that varying the isolation temperature between 600-1200℃ has tremendous impact on the production of TCP from fish bone waste with the required properties.

关键词： Hydroxyapatite tri-calcium phosphate fish bone heat treatement bioceramic

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Advanced protein adsorption properties of a novel silicate-based bioceramic: A proteomic analysis

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Bioactive Materials 2021年第1期6卷 208-218页

作者： Fanyan Deng Wanyin Zhai Yue Yin Chao Peng Congqin Ning State Key Laboratory of High Performance Ceramics and Superfine Microstructure Institute of CeramicsChinese Academy of SciencesShanghai200050China The Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials Shanghai Normal UniversityShanghai200234China National Facility for Protein Science in Shanghai Zhangjiang LabShanghai Advanced Research InstituteChinese Academy of ScienceShanghai201210China

Silicate bioceramics have been shown to possess excellent cytocompatibility and osteogenic activity,but the exact mechanism is still *** adsorption is the first event taking place at the biomaterial-tissue interface,which is vital to the subsequent cellular behavior and further influence the biomaterial-tissue *** this work,the protein adsorption behavior of a novel CPS bioceramic was evaluated using the proteomics *** results showed that CPS adsorbed more amount and types of serum proteins than ***1 and IGF1 proteins selected from proteomics results were validated by Western-blot *** analysis also revealed mechanistic insights how these absorbed proteins by CPS help mediate cell adhesion and promotes osteogenic ***,the dramatically enhanced adsorption of FN1 could greatly promote cell adhesion and ***,IGF1 was uniquely adsorbed on CPS bioceramic and IGF1 could activate Rap1 signaling pathway to promote cell ***,the increased adsorption of FN1,IGF1 and COL1A2 proteins on CPS explains its better ability on bone regeneration than ***,the increased adsorption of IGF1,CHAD,COL2A1 and THBS4 proteins on CPS explains its ability on cartilage ***,the increased adsorption of immunological related proteins on CPS may also play a positive role in bone *** addition,CPS had a much better cell adhesion ability than HA,proving that more adsorbed proteins really had a positive effect on cell *** more adsorbed proteins on CPS than HA might indicated a better bone regeneration rate at early stage of implantation.

关键词： Silicocarnotite bioceramic Protein adsorption Proteomics Pathway

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Laser surface coating of RE bioceramic layer on TC4

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中国有色金属学会会刊：英文版 2000年第4期10卷 477-480页

作者：高家诚张亚平文静王勇 Chongqing Univ Coll Mat Sci & Engn Chongqing 400044 Peoples R China

A layer of premixed CaHPO 4·2H 2O CaCO 3 Y 2O 3 powders stuck on pretreated surface of Ti 6Al 4V alloy substrate was successfully transformed into a composite of rare earth bioceramic coating by laser synthesizing and cladding only once. The microstructure and properties of the coating material were introduced. The titanium alloy with bioceramic coating on one side were implanted into the femur bone and thigh muscles of adult Mongrel dogs for testing its biocompatibility. The results of implantation experiments show that the microstructure of the coating material is static, the bonding properties between coating and substrate are better. The bioceramic coating had not toxicity side effectiveness on the body and there is a better compatibility of osteoconducton. No effect of the coating material on the bio activity of osteoblast and osteoclast was found.

关键词： laser cladding bioceramic coating biocompatibility rare earth

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Dynamics of Gradient bioceramic Composite Coating on Surface of Titanium Alloy by Wide-Band Laser Cladding

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Journal of Iron and Steel Research International 2004年第6期11卷 57-62页

作者： LIUQi-bin ZOULong-jiang ZHUWei-dong LIHai-tao DONGChuang DalianUniversityofTechnology Dalian116024China GuizhouUniversityofTechnology Guiyang550003China

The gradient bioceramic coating was prepared on the surface of titanium alloy using wide-band laser *** dynamics of gradient bioceramic composite coating containing hydroxyapatite(HA)prepared with mixture of CaHPO4·2H2O and CaCO3 under the condition of wide-band laser was studied *** corresponding mathematical model and its numerical solution were *** examination experiment showed that HA bioceramic composite coatings can be obtained by appropriately choosing wide-band laser cladding *** microstructure and surface morphology of HA bioceramic coating were observed by SEM and X-ray *** experimental results showed that the bioceramic coating is composed of HA,β-TCP,CaO,CaTiO3 and *** surface of bioceramic coating takes coral-shaped structure or short-rod piled structure,which helps osteoblast grow into bioceramic and improves the biocompatibility.

关键词： wide-band laser cladding bioceramic composite coating dynamics

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FHA bioceramic COMPOSITE MATERIALS ENHANCED BY ZrO_2

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Journal of Central South University 1994年第1期6卷 19-22页

作者： Ruan Jianmin Huang Baiyun(Powder Metallurgy of Research Institute, Central SouthUniversity of Technology, Changsha, 410083,China ) 1. Powder Metallurgy of Research Institute Central South University of Technology 410083 Changsha China

Experiments for investigating the problem to improve the mechanical properties of FHA [Ca(10) (PO4)6F(OH)] biomaterial have been presented in this paper. ZrO2 micro-particle, as strengthening phase, is added into FHA matrix material to make a composite biomaterial. Various mechanical properties were tested. Distribution be haviour of ZrO2 particle in sintered material and phase structure ' changes of material at elevated temperature were investigated by means of X-ray and SEM. Some biologic experiments were also carried out on animals to estimate the biological function of the corn posite material.

关键词： bioceramic mechanical properties microstructure phase structure

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Additive Manufacturing of Hydroxyapatite bioceramic Scaffolds with Projection Based 3D Printing

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Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers) 2022年第2期1卷 16-24页

作者： Huifeng Shao Zhiheng Nian Zhuoluo Jing Tao Zhang Jiahua Zhu Xiang Li Youping Gong Yong He School of Mechanical Engineering Hangzhou Dianzi UniversityHangzhou310018China State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou310027China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhou310027China Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing Nanjing Normal UniversityNanjing210023China

Hydroxyapatite(HA)bioceramics have garnered considerable attention owing to their applications in the field of bone repair and excellent *** to extrusion-based 3D printing,projection-based 3D print-ing(3DPP)can fabricate parts with complex geometry,high accuracy,and efficiency,which is very promising for bioceramic ***,conventional 3DPP using a paste with low viscosity will cause severe shrinkage of the parts after sintering,which makes it unsuitable for bioceramic scaffolds,and a system investigation of the printing process remains *** this study,we proposed a 3DPP device suitable for bioceramic scaffolds and investigated the additive manufacturing of HA *** paste properties and process parameters of curing,debinding,and sintering were initially *** mechanical properties,shrinkage,and biocompati-bility in vitro of the sintered samples were further *** obtained results indicate that HA bioceramics with uniform morphology,complex structure,and high accuracy can be manufactured using the 3DPP *** scaffolds have the mechanical strength of human cancellous bone,while HA scaffolds cultured with osteoblast precursor cells possess strong biocompatibility and can promote osteoblast adhesion,proliferation,and *** results suggest a promising application of the 3DPP technique in the preparation of bioceramic scaffolds,and the HA scaffolds fabricated using the 3DPP technique exhibit promising potential in fulfilling a constructive role in the biomedical field of human bone regeneration repair.

关键词： Projection based 3D printing Hydroxyapatite Scaffold Biosafety bioceramic

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Comparison of Apical Leakage in Root Canal Obturation Using bioceramic and Polydimethylsiloxane Sealer (<i>In Vitro</i>)

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Open Journal of Stomatology 2018年第1期8卷 24-34页

作者： Bina Amanda Endang Suprastiwi Munyati Usman Resident of Department of Conservative Dentistry Faculty of Dentistry Universitas Indonesia Jakarta Indonesia Departement of Conservative Dentistry Faculty of Dentistry Universitas Indonesia Jakarta Indonesia

Background: One of the ideal properties of a root canal sealer is to have a good sealing ability, especially at the apical third of the root. Objective: To evaluate the comparison of the apical leakage between obturation using bioceramic sealer (BS) and polydimethylsiloxane sealer (PS). Materials and Methods: Thirty-six mandibular premolars were equally divided into two groups and were obturated with single cone technique. The sealers used for Group I and Group II were BS and PS respectively. After obturation, the samples were incubated (37°C, 24 h), sealed with two coats of nail polish except for 2 mm from the apex, submerged in the Indian ink for 7 days, decalcified, dehydrated, and made transparent according to Robertson technique. Dye penetration was evaluated under stereomicroscope. Samples without dye penetration were given score 0, dye penetration ≤ 0.5 mm were given score 1, 0.51 - 1 mm were given score 2, and >1 mm were given score 3. Result: The largest proportion distribution in BS group was at the score 1 (55.6%), whereas in PS group was at the score 2 (44.4%). Conclusion: bioceramic sealer showed similar apical leakage to polydimethylsiloxane sealer. Clinical Relevance: Based on this study, bioceramic sealer can be recommended to be used as sealer with low level of apical leakage as well as polydimethylsiloxane sealer.

关键词： bioceramic Sealer Polydimethylsiloxane Sealer Apical Leakage

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Sol-gel bioceramic material from bentonite clay

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Journal of Biomedical Science and Engineering 2013年第3期6卷 258-264页

作者： Enobong R. Essien Luqman A. Adams Rafiu O. Shaibu Aderemi Oki Department of Chemical Sciences Bells University of Technology Ota Nigeria Department of Chemistry Faculty of Science University of Lagos Lagos Nigeria Department of Chemistry Prairie View A & M University Prairie View USA

bioceramic material of the quaternary system;SiO2- CaO-Na2O-P2O5 that has composition similar to Bio- glass? 45S5 was prepared by the sol-gel method from locally obtained bentonite clay (BTC). The monolith obtained was sintered at 1000?C for 2 h to facilitate densification and phase transformation. X-ray diffraction (XRD) analysis revealed the presence of sodium calcium silicate, Na2Ca2Si3O9 as major crystal phase, and another secondary orthorhombic phase, NaCaPO4. Fourier transform infrared (FTIR) spectroscopic investigation confirmed the presence of Si-O-Si bonds and a crystalline phosphate in the glass network. Scanning electron microscopy (SEM) revealed a network of micropores and interconnected macropores. Overall, the material displays features amenable for possible utilization in tissue engineering scaffolds.

关键词： bioceramic Sol-Gel Monolith Bentonite Clay Silica

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