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Dielectric Investigations on How Mg Salt Is Dispersed in and Released from Polylactic Acid

Chinese Journal of Polymer Science 2014年第4期32卷 497-508页

作者： Yu-jie Cao 朱丹 To Ngai Ling Qin Chi Wu Jian Shen Jiangsu Key Laboratory of Bio-functional Materials College of Chemistry and Materials ScienceNanjing Normal University Department of Chemistry The Chinese University of Hong Kong The Musculoskeletal Research Laboratory Department of Orthopaedics and TraumatologyThe Chinese University of Hong Kong

Composite biomaterials made of biodegradable polylactic acid （PLA） and bioactive magnesium （Mg） salt are developed for orthopaedic implants or metal implant coatings. The releasing of Mg salt into the biological environment benefits the bone growth, while with the releasing of Mg salt and degradation of PLA there forms a porous scaffold for tissue engineering. The size and morphology of the salt and voids are adjustable with such preparation conditions as salt content, pH of casting solution, and the solidification rate, so that we can control the salt releasing and degradation rate of PLA. Dielectric spectroscopy is used to investigate the dispersive structures of Mg salt and voids in the polymer matrix and to monitor the in situ releasing of Mg salts in the simulated body fluid （SBF）. The current study provides us with an orthopedic biomaterial with controllable multi-phase structures, and a tool to investigate the in vivo behaviors of biomaterials.

关键词： Dielectric spectroscopy Inorganic-polymer composite Orthopaedic biomaterials Biodegradation bioactivity.

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Synthesis of Novel Antifungal Triazole Compounds

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Chinese Chemical Letters 2004年第9期15卷 1011-1014页

作者： YongCHU MingXiaXU DingLU PharmacySchoolofWestChina SichuanUniversityChengdu610041 SichuanInstituteofAntibioticIndustry Chengdu610051

Based on our previous studies of 3D-QSAR, 38 novel objective compounds belonging to 4 series were designed and successfully synthesized directed by the idea of reconstructing the structure of non-pharmacophores while reserving essential ones in triazoles. In vitro pilot studies on their antifungal activities showed that most compounds have inhibitory effects on *** and some inhibit *** also. The effects on *** of 5 compounds are more potent than or equal to that of fluconazole or itraconazole.

关键词： Triazole antifungal synthesis bioactivity.

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Cloning and high-level expression of plasminogen activator inhibitor-1 cDNA derived from human glomerular mesangial cells

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Science China(Life Sciences) 1998年第3期41卷 315-322页

作者：邓义斌陈香美廖洪军叶一舟徐启河于力方 Department of Nephrology General Hospital of PLA 100853 Beijing China

Translation reading frame of human plasminogen activator inhibitor 1 (PAI 1) cDNA was amplified from total RNA extracted from glomerular mesangial cells by using reverse transcription polymerase chain reaction (RT PCR) and inserted into plasmid pUC19 in a sense orientation. Sequencing results revealed that PAI 1 cDNA had new initial codon ATG, but no signal peptide sequences, and translation reading frame was in agreement with PAI 1 cDNA derived from human endothelial cells. PAI 1 cDNA determined by sequencing was inserted into prokaryotic expression plasmid pBV220, and recombinant plasmid pBV220 PAI 1 which had high level expression in Escherichia coli was obtained. Recombinant PAI 1 protein attained to approximately 45% of total bacterial proteins. Western blotting showed that there was a specific band in the region of 43.0 ku. Latent recombinant PAI 1 with 97% purity was obtained from inclusion bodies after denaturation, renaturation and purification by FPLC. Recombinant PAI 1 activated by treatment with 4.0 mol/L guanidinium hydrochloride had significant inhibition activity to u PA and shared bioactivity.in common with natural PAI 1.

关键词： human plasminogen activator inhibitor 1 molecular cloning recombinant bioactivity.

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Production of Bone-like 40%nylon6,6-Nano Hydroxyapatite Scaffold via Salt-Leaching/Solvent Casting Technique

Production of Bone-like 40%nylon6,6-Nano Hydroxyapatite Scaf...

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International Conference on Chemistry and Chemical Engineering （ICCCE 2011）

作者： Mojtaba Nasr-Esfahani Mehran Mehrabanian Department of Materials Science Najafabad Branch Islamic Azad University Esfahan IRAN Member of Young Researchers Club Najafabad Branch Islamic Azad University Esfahan IRAN

As in situ synthesized N-HA/nylon6,6 powder is used for production of three-dimensional porous scaffolds which play an important role in tissue engineering. A new method of preparing porous scaffolds using nanocomposite powder was developed by salt leaching/solvent Casting Technique using NaCl crystals as the porogen material. The pore structures of the nanocomposite scaffold could be manipulated by controlling processing variables such as the size and weight fraction of the NaCl crystals and the nylon6,6 concentration. The morphologies, mechanical properties and in vitro bioactivity.of the composite scaffolds were investigated. It was noted that the pore architectures could be manipulated by salt leaching parameters. The n-HA particles were dispersed in the pore walls of the scaffolds and were well bonded to nylon6,6. The introduction of HA greatly increased the stiffness and strength, and improved the in vitro bioactivity.of the scaffolds. The results suggest these newly developed nano-HA/nylon6,6 composite scaffolds may serve as an effective three-dimensional substrate in bone tissue engineering.

关键词： scaffold nano hydroxyapatite nylon6 6 salt-leaching/solvent casting bioactivity.

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