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Bioprinting and regeneration of auricular cartilage using a bioactive bioink based on microporous photocrosslinkable acellular cartilage matrix

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bioactive Materials 2022年第10期7卷 66-81页

作者： Litao Jia Yujie Hua Jinshi Zeng Wenshuai Liu Di Wang Guangdong Zhou Xia Liu Haiyue Jiang Research Center of Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100144PR China Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Key Laboratory of Tissue EngineeringShanghai Jiao Tong University School of MedicineShanghai200011PR China Research Institute of Plastic Surgery Weifang Medical UniversityWeifang261042PR China

Tissue engineering provides a promising strategy for auricular *** the first international clinical breakthrough of tissue-engineered auricular reconstruction has been realized based on polymer scaffolds,this approach has not been recognized as a clinically available treatment because of its unsatisfactory clinical *** is mainly since reconstruction constructs easily cause inflammation and *** this study,we present a novel strategy for the development of biological auricle equivalents with precise shapes,low immunogenicity,and excellent mechanics using auricular chondrocytes and a bioactive bioink based on biomimetic microporous methacrylate-modified acellular cartilage matrix(ACMMA)with the assistance of gelatin methacrylate(GelMA),poly(ethylene oxide)(PEO),and polycaprolactone(PCL)by integrating multi-nozzle bioprinting *** ACMMA is used to emulate the intricacy of the cartilage-specific microenvironment for active cellular behavior,while GelMA,PEO,and PCL are used to balance printability and physical properties for precise structural stability,form the microporous structure for unhindered nutrient exchange,and provide mechanical support for higher shape fidelity,***,mature auricular cartilage-like tissues with high morphological fidelity,excellent elasticity,abundant cartilage lacunae,and cartilage-specific ECM deposition are successfully regenerated in vivo,which provides new opportunities and novel strategies for the fabrication and regeneration of patient-specific auricular cartilage.

关键词： 3D bioprinting Photocrosslinkable acellular cartilage matrix bioactive bioink Microporous Auricular cartilage regeneration

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