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Decellularized extracellular matrix biomaterials for regenerative therapies:Advances,challenges and clinical prospects

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bioactive Materials 2024年第2期32卷 98-123页

作者： Aleksandra A.Golebiowska Jonathon T.Intravaia Vinayak M.Sathe Sangamesh G.Kumbar Syam P.Nukavarapu Department of biomedical Engineering University of ConnecticutStorrsCT06269USA Department of Materials Science&Engineering University of ConnecticutStorrsCT06269USA Department of Orthopaedic Surgery University of Connecticut HealthFarmingtonCT06032USA

Tissue engineering and regenerative medicine have shown potential in the repair and regeneration of tissues and organs via the use of engineered biomaterials and ***,current constructs face limitations in replicating the intricate native microenvironment and achieving optimal regenerative capacity and functional *** address these challenges,the utilization of decellularized tissues and cell-derived extracellular matrix(ECM)has emerged as a promising *** biocompatible and bioactive biomaterials can be engineered into porous scaffolds and grafts that mimic the structural and compositional aspects of the native tissue or organ microenvironment,both in vitro and in *** dECM materials provide a unique tissue-specific microenvironment that can regulate and guide cellular processes,thereby enhancing regenerative *** this review,we explore the emerging frontiers of decellularized tissue-derived and cell-derived biomaterials and bio-inks in the field of tissue engineering and regenerative *** discuss the need for further improvements in decellularization methods and techniques to retain structural,biological,and physicochemical characteristics of the dECM products in a way to mimic native tissues and *** article underscores the potential of dECM biomaterials to stimulate in situ tissue repair through chemotactic effects for the development of growth factor and cell-free tissue engineering *** article also identifies the challenges and opportunities in developing sterilization and preservation methods applicable for decellularized biomaterials and grafts and their translation into clinical products.

关键词： Non-immune biomaterials and grafts Native micro-environment bio-chemical cues Chemotactic ability Tissue-inks Clinical therapies

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