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Normalizing the Neural Correlates of binge-eating Disorder with Lisdexamfetamine: A Case Report and Literature Review

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Open Journal of Psychiatry 2018年第2期8卷 142-151页

作者： Leyla R. Brucar Amna Hyder Carl Laird Birmingham University of British Columbia Vancouver BC Canada Masters Program in Neuroscience University of British Columbia Vancouver BC Canada Department of Psychiatry University of British Columbia Vancouver BC Canada

The brain regions associated with binge-eating disorder (BED) and those targeted by Lisdexamfetamine (LDX) overlap. The present paper reviews the psychobehavioural and neuropharmacological mechanisms at play in BED and compulsive eating behaviours, along with the mechanisms of action LDX is thought to play. We present one case of chronic BED and highlight the EEG scans pre- and post-LDX treatment. The normalization of the patient’s electroencephalogy (EEG) activity associated with BED after LDX supports theorized mechanisms of LDX action, further explaining its efficacy in treatment. A significant decrease in theta band power was observed in the patient after treatment with LDX. Specifically, this decrease was modulated by changes in the F8 electrode corresponding to the orbitofrontal cortex (OFC)—An area associated with deficits in inhibitory function, seen in addictions and BED. A better understanding of the psychobehavioural and neuropharmacological mechanisms involved in BED and LDX treatment has the potential to significantly enhance our knowledge of the underlying pathogenesis, potential prevention, and optimal treatment options for patients.

关键词： binge-eating Disorder Lisdexamfetamine Brain Mechanisms Compulsive eating EEG LORETA Power Spectral Density Theta Band

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