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bimetallic nanoparticles as cascade sensitizing amplifiers for low-dose and robust cancer radio-immunotherapy

Acta Pharmaceutica Sinica B 2024年第4期14卷 1787-1800页

作者： Yupeng Wang Lina Wang Tao Li Min Ouyang Hejian Xiong Dongfang Zhou Department of Ultrasonic Diagnosis Zhujiang HospitalKey Laboratory of Mental Health of the Ministry of EducationNMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Testing and Analysis Center Hebei Normal UniversityShijiazhuang 050024China Department of Mechanical Engineering The University of Texas at DallasRichardsonTX 75080USA

Radiotherapy(RT)is one of the most feasible and routinely used therapeutic modalities for treating malignant *** particular,immune responses triggered by RT,known as radio-immunotherapy,can partially inhibit the growth of distantly spreading tumors and recurrent ***-ever,the safety and efficacy of radio-immunotherapy is impeded by the radio-resistance and poor immu-nogenicity of ***,we report oxaliplatin(IV)-iron bimetallic nanoparticles(OXA/Fe NPs)as cascade sensitizing amplifiers for low-dose and robust *** OXA/Fe NPs exhibit tumor-specific accumulation and activation of OXA(I)and Fe^(2+)in response to the reductive and acidic microenvironment within tumor *** cascade reactions of the released metallic drugs can sensitize RT by inducing DNA damage,increasing ROS and O_(2) levels,and amplifying the immunogenic cell death(ICD)effect after RT to facilitate potent immune *** a result,OXA/Fe NPs-based low-dose RT triggered a robust immune response and inhibited the distant and metastatic tumors effectively by a strong abscopal ***,a long-term immunological memory effect to protect mice from tumor rechal-lenging is ***,the bimetallic NPs-based cascade sensitizing amplifier system offers an effi-cient radio-immunotherapy regimen that addresses the key challenges.

关键词： bimetallic nanoparticles Radio-immunotherapy Cascade sensitizing amplifier,Oxaliplatin Fenton-typeHaber-Weiss reaction Radiosensitization Immunogenic cell death Radio-resistance

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Kinetics and Morphological Analysis of Silver Platinum bimetallic nanoparticles

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Acta Metallurgica Sinica(English Letters) 2016年第4期29卷 320-325页

作者： Fredrick Okumu Mangaka Matoetoe Department of Chemistry Cape Peninsula University of Technology

Kinetics of a one-pot core-shell synthesis of bimetallic （BM） silver-platinum （Ag-Pt） nanoparticles （NPs） by simultaneous reduction of 1：1 mol fraction of precursors H2PtC16.6H20 and AgNO3 in aqueous solution is reported. Kinetics analysis was done by plotting UV-visible absorptions versus reaction time with a first-order fitting. Recorded constants of Ag NPs （0.079 s^-1）, Ag-Pt NPs 1：1 （0.082 s^-1）, and Pt NPs （0.006 s^-1） were obtained. The NPs suspension solutions were clear, free from AgCl precipitate, and had characteristic optical properties of 450 nm （Ag NPs）, while there were no observable bands for Pt and BM NPs. Morphological analysis using transmission electron microscopy, energy- dispersive X-ray spectroscopy （EDX）, and selected area electron diffraction （SAED） depicted spherical aggregates of Ag NPs, Pt NPs and core shell Pt-Ag NPs 1：1 of average size of 60, 2.5, and 20 mm, respectively. Presence of the Ag and Pt elemental composition in the nanoparticle suspensions was confirmed by EDX. SAED ring patterns revealed a single facecentered cubic crystalline nature of Ag NPs and showed typical Pt-based BMs randomly overlapped ring pattern with sharp diffraction spots.

关键词： Platinum Silver bimetallic nanoparticles Kinetics Morphology

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Microfluidic-enabled ambient-temperature synthesis of ultrasmall bimetallic nanoparticles

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Nano Research 2022年第1期15卷 248-254页

作者： Huayi Shi Bin Song Runzhi Chen Qiang Zhang Guyue Hu Jing Li Jinhua Wang Xinyu Meng Houyu Wang Yao He Laboratory of Nanoscale Biochemical Analysis Institute of Functional Nano and Soft Materials(FUNSOM)and Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhou 215123China Department of Instrument Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The production of bimetallic nanoparticles with ultrasmall sizes is the constant pursuit in chemistry and materials science because of their promising applications in catalysis,electronics and *** we report ambient-temperature preparation of bimetallic NPs with tunable size and composition using microfluidic-controlled co-reduction of two metal precursors on silicon *** of free diffusion of metal ions in bulk system,microfluidic flow could well control the local ions concentration,thus leading to homogenous and controllable reduction rate among different nucleation *** controlling precursor concentration,flow rate and reaction time,we rationally design a series of bimetallic NPs including Ag-Cu,Ag-Pd,Cu-Pt,Cu-Pd and Pt-Pd NPs with ultrasmall sizes(~3.0 nm),tight size distributions(relative standard deviation(RSD)bimetallic NPs with excellent activity.

关键词： bimetallic nanoparticles microfluidics silicon surface co-reduction ultrasmall

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Structural optimization of Au–Pd bimetallic nanoparticles with improved particle swarm optimization method

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Chinese Physics B 2017年第6期26卷 131-139页

作者：邵桂芳朱梦上官亚力李文然张灿王玮玮李玲 Department of Automation Xiamen University Xiamen 361005 China

Due to the dependence of the chemical and physical properties of the bimetallic nanoparticles（NPs） on their structures,a fundamental understanding of their structural characteristics is crucial for their syntheses and wide applications. In this article, a systematical atomic-level investigation of Au–Pd bimetallic NPs is conducted by using the improved particle swarm optimization（IPSO） with quantum correction Sutton–Chen potentials（Q-SC） at different Au/Pd ratios and different sizes. In the IPSO, the simulated annealing is introduced into the classical particle swarm optimization（PSO） to improve the effectiveness and reliability. In addition, the influences of initial structure, particle size and composition on structural stability and structural features are also studied. The simulation results reveal that the initial structures have little effects on the stable structures, but influence the converging rate greatly, and the convergence rate of the mixing initial structure is clearly faster than those of the core-shell and phase structures. We find that the Au–Pd NPs prefer the structures with Au-rich in the outer layers while Pd-rich in the inner ones. Especially, when the Au/Pd ratio is 6：4, the structure of the nanoparticle（NP） presents a standardized Pd（core） Au（shell） structure.

关键词： bimetallic nanoparticles stable structures particle swarm optimization (PSO) simulated annealing

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Removing polybrominated diphenyl ethers in pure water using Fe/Pd bimetallic nanoparticles

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Frontiers of Environmental Science & Engineering 2015年第5期9卷 832-839页

作者： Min ZHANG Jian LU ZhenchengXU Yiliang HF Bo ZHANG Song JIN Brian BOMAN School of Environmental Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China Indian River Research and Education-Cenierl U-niversi-ty- of-Florida Fort PierceFL34945USA South China Institute of Environment Sciences Ministry of Environmental Protection Guangzhou 510655 China Department of Civil and Architectural Engineering University of Wyoming Laramie WY 82071 USA

Polybrominated diphenyl ethers （PBDEs） have been widely used as fire-retardants. Due to their high production volume, widespread usage, and environmental persistence, PBDEs have become ubiquitous contaminants in various *** zero-valent iron （ZVI） is an effective reductant for many halogenated organic compounds. To enhance the degradation efficiency, ZVI/ Palladium bimetallic nanoparticles （nZVI/Pd） were synthe- sized in this study to degrade decabromodiphenyl ether （BDE209） in water. Approximately 90% of BDE209 was rapidly removed by nZVI/Pd within 80 min, whereas about 25% of BDE209 was removed by nZVL Degradation of BDE209 by nZVI/Pd fits pseudo-first-order kinetics. An increase in pH led to sharply decrease the rate of BDE209 degradation. The degradation rate constant in the treatment with initial pH at 9.0 was more than 6.8 x higher than that under pH 5.0. The degradation intermediates of BDE209 by nZVI/Pd were identified and the degradation pathways were hypothesized. Results from this study suggest that nZV//Pd may be an effective tool for treating polybromi- nated diphenyl ethers （PBDEs） in water.

关键词： bimetallic nanoparticles nanoscale zerovalent iron polybrominated diphenyl ethers degradation

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Fabrication of bimetallic nanoparticles modified hollow nanoporous carbons derived from covalent organic framework for efficient degradation of 2,4-dichlorophenol

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Chinese Chemical Letters 2021年第8期32卷 2529-2533页

作者： Yanshu Zhang Gongke Li Yufei Hu School of Chemistry Sun Yat-sen UniversityGuangzhou 510275China

bimetallic nanoparticles modified hollow-structured nanoporous carbons(NPCs) have been fabricated via a convenient one-step carbonizing strategy derived from covalent organic *** Pd/Fe/NPCs,Pt/Fe/NPCs and Rh/Fe/NPCs were obtained and can be used as Fenton-like catalysts with good stability and *** catalytic activity was evaluated by the degradation of2,4-dichlorophenl(2,4-DCP).These fabricated bimetallic catalysts exhibited much higher catalytic activity than Fe/NPCs at room *** enhancement of catalytic ability was benefited from synergetic catalytic effect of bimetallic nanoparticles and accelerated mass transfer of hollow ***,the enhanced catalytic mechanism of bimetallic catalysts was studied in detail and the reasonable reaction pathway was ***,the bimetallic catalysts were successfully used for degradation of 2,4-DCP in actual industrial wastewater and the removal efficiency could reach 74.3%within 120 min,which demonstrated the promising potential application of bimetallic catalysts in the removal of pollutants in environment.

关键词： Covalent organic framework Hollow structure N-doped carbon bimetallic nanoparticles 2 4-Dichlorophenol Degradation

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Amine facilitates the synthesis of silica-supported ultrasmall bimetallic nanoparticles

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Science China Materials 2018年第8期61卷 1129-1131页

作者： Nanfeng Zheng Pengxin Liu Collaborative Innovation Center of Chemistry for Energy Materials State Key Laboratory for Physical Chemistry of Solid Surfaces and Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University

Supported catalysts based on metal nanoparticles are a class of widely used heterogeneous catalysts in *** catalytic performances of supported metal catalysts are highly determined by many parameters of metal nanopart... 详细信息

关键词： Amine facilitates the synthesis of silica-supported ultrasmall bimetallic nanoparticles

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Determination of Hydrodynamic Parameters of Chitosan Stabilized bimetallic nanoparticles

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Journal of Metallic Material Research 2022年第1期5卷 32-37页

作者： Vokhidova N.R. Rashidova S.Sh. Institute of Chemistry and Physics of Polymers of Scientific Academy of Uzbekistan Uzbekistan

The hydrodynamic characteristics of bimetallic Ag/Cu and Co/Ag nanoparticles stabilized by chitosan were *** polydispersity index and the diameter of nanoparticles were observed to decrease in contrast to the original polymer during the creation of chitosan stabilized bimetallic nanoparticles,decreasing from 0.342 to 0.12±0.04 and 2.5 micron to 180 nm,***,the diffusion coefficient of chitosan was increased from 0.2 cm^(2)/s to 2.71 cm2/s during the production of stable bimetallic *** lack of absorption bands at 500 nm and 700 nm-900 nm in the UV spectra of the samples suggests that in the presence of a reducing agent,copper(II)and cobalt(II)ions undergo full *** relationship between the synthesis conditions and the kind of structure of bimetallic nanoparticles“core-shell”has been *** atoms have been shown to be both a core and a shell,depending on the synthesis conditions and chemical nature of metal ions.

关键词： Chitosan Bombyx mori bimetallic nanoparticles Index polydispersity Diffusion coefficient

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Characterization and Preparation of bimetallic nanoparticles

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复旦学报（自然科学版） 2007年第5期46卷 720-页

作者： Bing Joe Hwang Ching Hsiang Chen Loka Subramanyam Sarma Din-gao Liu Jyh Fu Lee Nanoelectrochemistry Laboratory Department of Chemical Engineering National Taiwan University of Science & Technology National Synchrotron Radiation Research Center

1 Results bimetallic particles in the nanometer size range are of substantial interest due to their vast applications in catalysis[1].The synthesis of bimetallic nanoparticles with definite size with a well-control over their nanostructure remains a challenging *** there exists a great demand for both synthesis and atomic level characterization of nanostructure of bimetallic nanoparticles (NPs).With the recent advent of high-intensity tunable sources of X-rays,now available at synchrotron radia...

关键词： bimetallic nanoparticles nanostructure characterization X-ray absorption spectroscopy

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Nano-fried-eggs： Structural, optical, and magnetic characterization of physically prepared iron-silver nanoparticles

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Nano Research 2018年第11期11卷 6074-6085页

作者： Julien Ramade Nicolas Troc Olivier Boisron Michel Pellarin Marie-Ange Lebault Emmanuel Cottancin Vitor T. A. Oiko Rafael Cabreira Gomes Varlei Rodrigues Matthias Hillenkamp Univ. Lyon Universitd Claude Bernard Lyon I CNRS UMR5306 Institut Lumiee Matiee t=-69622 Villeurbanne France Instituto de F[sica Gleb Wataghin UNICAMP CP 6165 13083-970 Campinas SP Brazil

The prospect of combining both magnetic and plasmonic properties in a single nanoparticle promises both valuable insights on the properties of such systems from a fundamental viewpoint and numerous possibilities for technological applications. However, the combination of two of the most prominent metallic candidatesiron and silverhas presented numerous experimental difficulties because their thermodynamic properties impede miscibility and even coalescence. Herein, we present the thorough characterization of physically prepared Fe50Ag50 nanoparticles embedded in carbon and silica matrices via electron microscopy, optical spectroscopy, magnetometry and synchrotron-based X-ray spectroscopy. Iron and silver segregate completely into structures resembling fried eggs, with a nearly spherical, crystallized silver part surrounded by an amorphous structure of iron carbide or oxide, depending on the environment of the particles. Consequently, the particles exhibit both plasmonic absorption corresponding to the silver nanospheres in an oxide environment and a reduced but measurable magnetic response. The suitability of such nanoparticles for technological applications is discussed from the viewpoint of their high chemical reactivity with their environment.

关键词： nanoalloy bimetallic nanoparticles iron silver FeAg optical spectroscopy magnetometry

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