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Effect Observation of Clinical Treatment with Oxaliplatin and Tiggio for biliary Tract tumors on Advanced Stage

Journal of Clinical and Nursing Research 2021年第3期5卷 66-68页

作者： Wei Zheng Haibin Wang Jiao Zhou Shaanxi Provincial People's Hospital Xi’an 710068Shaanxi ProvinceChina

Objective:To investigate the effect of oxaliplatin combined with tiggio in the treatment of advanced biliary tract ***:The research period was from November 2019 to November 2020.80 patients with advanced biliary tumor disease were *** were divided into groups according to the order of admission,with 40 cases in each *** control group received oxaliplatin combined with gemcitabine,and the experimental group received oxaliplatin combined with *** of adverse reactions,time to disease progression,survival time and clinical efficacy were checked and ***:Compared with the incidence of adverse reaction of the experimental group,which was 5.00%(2/40),the incidence of adverse reaction of the control group was 25.00%(10/40).The chi-square value=6.2745,p-value=*** time to progression and survival time of patients in the experimental group were shorter than those of the control group,with significant differences between the groups(pbiliary tract tumors has higher safety and reduces the incidence of adverse reactions.

关键词： Advanced stage biliary tumors Oxaliplatin Tiggio

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Liquid biopsy in cholangiocarcinoma:Current status and future perspectives

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World Journal of Gastrointestinal Oncology 2021年第5期13卷 332-350页

作者： Gianluca Rompianesi Marcello Di Martino Alex Gordon-Weeks Roberto Montalti Roberto Troisi Hepato-Bilio-Pancreatic Minimally Invasive and Robotic Surgery UnitDepartment of Clinical Medicine and SurgeryFederico II University HospitalNapoli 80131Italy Hepato-Bilio-Pancreatic Surgery Unit Department of General and Digestive SurgeryHospital Universitario La PrincesaMadrid 28006Spain Nuffield Department of Surgical Sciences University of OxfordOxford OX39DUUnited Kingdom

Cholangiocarcinoma(CCA)are a heterogeneous group of tumors in terms of aetiology,natural history,morphological subtypes,molecular alterations and management,but all sharing complex diagnosis,management,and poor *** mutated genes and epigenetic changes have been detected in CCA,with the potential to identify diagnostic and prognostic biomarkers and therapeutic *** tumoral components and genetic material is therefore crucial for the diagnosis,management and selection of targeted therapies;but sampling tumor tissue,when possible,is often risky and difficult to be repeated at different time *** biopsy(LB)represents a way to overcome these issues and comprises a diverse group of methodologies centering around detection of tumor biomarkers from fluid *** to the traditional tissue sampling methods LB is less invasive and can be serially repeated,allowing a real-time monitoring of the tumor genetic profile or the response to *** this review,we analysis the current evidence on the possible roles of LB(circulating DNA,circulating RNA,exosomes,cytokines)in the diagnosis and management of patients affected by CCA.

关键词： Liquid biopsy Cholangiocarcinoma Circulating biomarkers biliary tumors Circulating DNA Circulating RNA Exosomes Cytokines

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