检索结果-南通市图书馆

Liver tissue engineering using decellularized scaffolds:Current progress,challenges,and opportunities

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2024年第10期40卷 280-305页

作者： Kamal H.Hussein Boyukkhanim Ahmadzada Julio Cisneros Correa Ahmer Sultan Silvana Wilken Bruce Amiot Scott L.Nyberg Department of Surgery Mayo ClinicRochesterMNUnited States William J.von Liebig Center for Transplantation and Clinical Regeneration Mayo ClinicRochesterMNUnited States Department of Surgery Anesthesiologyand RadiologyCollege of Veterinary MedicineAssiut UniversityAssiutEgypt

Liver transplantation represents the only definitive treatment for patients with end-stage liver ***,the shortage of liver donors provokes a dramatic gap between available grafts and patients on the waiting *** liver bioengineering,an emerging field of tissue engineering,holds great potential to overcome this *** approach involves two main steps;the first is liver decellularization and the second is *** decellularization aims to remove cellular and nuclear materials from the organ,leaving behind extracellular matrices containing different structural proteins and growth factors while retaining both the vascular and biliary *** involves repopulating the decellularized liver with appropriate cells,theoretically from the recipient patient,to reconstruct the parenchyma,vascular tree,and biliary *** aim of this review is to identify the major advances in decellularization and recellularization strategies and investigate obstacles for the clinical application of bioengineered liver,including immunogenicity of the designed liver extracellular matrices,the need for standardization of scaffold fabrication techniques,selection of suitable cell sources for parenchymal repopulation,vascular,and biliary tree *** vivo transplantation models are also summarized for evaluating the functionality of bioengineered ***,the regulatory measures and future directions for confirming the safety and efficacy of bioengineered liver are also *** these challenges in whole liver bioengineering may offer new solutions to meet the demand for liver transplantation and improve patient outcomes.

关键词： Bioengineered liver Decellularization Recellularization Reendothelialization biliary reconstruction

Optimizing biliary outcomes in living donor liver transplantation:Evolution towards standardization in a high-volume center

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2020年第4期19卷 324-327页

作者： Tsan-Shiun Lin Jeffrey Samuel Co Chao-Long Chen Aldwin D.Ong Liver Transplantation Center Department of SurgeryKaohsiung Chang Gung Memorial Hospital123 Ta-Pei RoadNiao SungKaohsiung 833TaiwanChina

biliary complications have always been a dreaded cause of morbidity after living donor liver *** intrinsic variations in both graft and recipient biliary anatomy remain a significant factor to the difficulty of biliary reconstruction,our institution has taken advantage of its high volume of cases to critically review and evaluate modifiable operative risk factors,in particular,our surgical *** present herein,the evolution of our reconstructive biliary technique from conventional methods to our current standard of microsurgical biliary reconstruction for both graft and recipient *** this period of transition,our center has created a classification system for biliary reconstruction that decreased the biliary complication rates from 40.0%to 10.2%.

关键词： Living donor liver transplantation biliary reconstruction Microsurgical biliary reconstruction biliary classification biliary complications

Evaluation of the short-term outcomes of robotic-assisted radical resection for perihilar cholangiocarcinoma:a propensity-scored matching analysis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gastroenterology Report 2023年第1期11卷 254-259页

作者： Xi-Tai Huang Jin-Zhao Xie Jian-Peng Cai Wei Chen Liu-Hua Chen Li-Jian Liang Xiao-Yu Yin Department of Pancreato-biliary Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:The application of robotic-assisted radical resection in perihilar cholangiocarcinoma(pCCA)remains poorly *** study aimed to evaluate the safety and efficacy of robotic-assisted radical resection for pCCA in our ***:Between July 2017 and July 2022,pCCA patients undergoing robotic-assisted and open radical resection at First Affiliated Hospital of Sun Yat-sen University(Guangzhou,China)were *** short-term outcomes were compared by using propensity-scored matching(PSM)***:Eighty-six pCCA patients were *** PSM at a ratio of 1:2,10 and 20 patients were assigned to the roboticassisted and open groups,*** were no significant disparities in the clinicopathological features between the two *** robotic-assisted group had significantly longer operation time(median:548 vs 353 min,P=0.004)and larger total number of lymph nodes examined(median:11 vs 5,P=0.010)than the open *** robotic-assisted group tended to have a lower intraoperative blood loss(median:125 vs 350 mL,P=0.067),blood transfusion rates(30.0%vs 70.0%,P=0.056),and post-operative overall morbidities(30.0%vs 70.0%,P=0.056)than the open group,even though the differences were not statistically *** were no significant differences in the negative resection margin,post-operative major morbidities,or post-operative length-of-stay between the robotic-assisted and open groups(all P>0.05).Conclusions:Robotic-assisted radical resection of pCCA may get a larger total number of lymph nodes examined than open *** robotic-assisted surgery may be a feasible and safe technique for selected pCCA patients.

关键词： robotic-assisted surgery perihilar cholangiocarcinoma biliary reconstruction

Comparatively lower postoperative hepatolithiasis risk with hepaticocholedochostomy versus hepaticojejunostomy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2010年第1期9卷 38-43页

作者： Zhang, Xiao-Jin Jiang, Yi Wang, Xu Tian, Fu-Zhou Lv, Li-Zhi Fujian Med Univ Dept Hepatobiliary Surg Fuzong Clin Coll Fuzhou 350025 Peoples R China Fujian Med Univ Dept Nursing Fuzong Clin Coll Fuzhou 350025 Peoples R China PLA Fuzhou Gen Hosp Nanjing Mil Area Command Dept Hepatobiliary Surg Ctr Hepatobiliary Dis Fuzhou 350025 Peoples R China PLA Fuzhou Gen Hosp Chengdu Mil Area Command Dept Gen Surg Chengdu 610083 Peoples R China

BACKGROUND: Optimal surgical technique plays a key role in preventing the postoperative recurrence of hepatolithiasis. Tian et al developed the subcutaneous tunnel and hepatocholangioplasty using the gallbladder (STHG) technique and applied it in hepatolithiasis patients who had an approximately normal gallbladder and sphincter of Oddi. However, the technique is controversial. In the present study, a canine model was established for hepatocholangioplasty (HC) and hepaticojejunostomy (HJ) to simulate STHG and Roux-en-Y cholangiojejunostomy in the clinic, respectively. Then, the alterations of bile components in the vicinity of the anastomosis were compared. This may provide an experimental guide for choosing an optimal technique for the treatment of hepatolithiasis in the clinic. METHODS: The animals were randomly separated into a control group (5 dogs) and a model group (stenosis of the common bile duct; 24 dogs). The 24 dogs in the model group were randomly divided into an HC group and an HJ group (12/group). Bile was collected from the bile duct at I and 5 months after the operation, and the bile components were determined. RESULTS: The levels of total bile acid, cholesterol, total bilirubin, and phospholipid in the HC group were higher than those in the HJ group (P<0.05). However, no statistical difference was seen in unconjugated bilirubin and calcium ions. The mucin level in bile in the HC group was lower than that in the HJ group at 5 months after the operation (P<0.05). The postoperative lipid peroxidation level was remarkably lower than that in the HJ group (P<0.05). However, the superoxide dismutase level was remarkably higher than that in the HJ group (P<0.05). Finally, a significant difference was found in the positive bacterial culture rate in bile between the groups. CONCLUSION: Changes of bile components near the anastomosis after HC might be more preferable for preventing hepatolithiasis formation than HJ.

关键词： hepatocholangioplasty cholangiojejunostomy hepatolithiasis gallstones biliary reconstruction hepaticocholedochostomy

Timing of surgical repair of bile duct injuries after laparoscopic cholecystectomy: A systematic review

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2022年第2期14卷 442-455页

作者： Patryk Kambakamba Sinead Cremen Beat Möckli Michael Linecker Department of HPB and Transplant Surgery St.Vincent’s University Hospital DublinDublin d04 T6F4Ireland Department of Surgery Cantonal Hospital GlarusGlarus 8750Switzerland Department of Visceral and Transplantation Surgery University of Geneva HospitalsGeneva 1205Switzerland Department of Surgery and Transplantation University Medical Center Schleswig HolsteinKiel 24105Germany

BACKGROUND The surgical management of bile duct injuries(BDIs)after laparoscopic cholecystectomy(LC)is challenging and the optimal timing of surgery remains *** primary aim of this study was to systematically evaluate the evidence behind the timing of BDI repair after LC in the *** To assess timing of surgical repair of BDI and postoperative *** The MEDLINE,EMBASE,and The Cochrane Library databases were systematically screened up to August *** of bias was assessed via the Newcastle Ottawa *** primary outcomes of this review included the timing of BDI repair and postoperative *** A total of 439 abstracts were screened,and 24 studies were included with 15609 patients included in this *** the 5229 BDIs reported,4934(94%)were classified as major *** of bile duct repair was immediate(14%,n=705),early(28%,n=1367),delayed(28%,n=1367),or late(26%,n=1286).Standardization of definition for timing of repair was remarkably poor among *** for immediate repair ranged from24 h to>12 wk after LC)and late repair(>6 wk after LC)showed a broad *** The lack of standardization among studies precludes any conclusive recommendation on optimal timing of BDI repair after *** finding indicates an urgent need for a standardized reporting system of BDI repair.

关键词： Bile duct injury Major bile duct injury Laparoscopic cholecystectomy Surgical repair Immediate repair Early repair Delayed repair Late repair biliary reconstruction Standardization of bile duct injury repair reporting

Pyogenic liver abscess after choledochoduodenostomy for biliary obstruction caused by autoimmune pancreatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第39期12卷 6397-6400页

作者： Nobuyuki Toshikuni Kyohei Kai Shizo Sato Motoko Kitano Masayoshi Fujisawa Hiroaki Okushin Kazuhiko Morii Shinjiro Takagi Masahiro Takatani Hirofumi Morishita Koichi Uesaka Shiro Yuasa Department of Internal Medicine Himeji Red Cross Hospital Himeji Japan Department of Surgery Himeji Red Cross Hospital Himeji Japan Department of Pathology Himeji Red Cross Hospital Himeji Japan

A 68-year-old man underwent cholecystectomy and choledochoduodenostomy for biliary obstruction and nephrectomy for a renal tumor. Based on clinical and histopathologic findings, autoimmune pancreatitis (AIP) was diagnosed. The renal tumor was diagnosed as a renal cell cancer. Steroid therapy was started and thereafter pancreatic inflammation improved. Five years after surgery, the patient was readmitted because of pyrexia in a preshock state. A Klebsiella pneumoniae liver abscess complicated by sepsis was diagnosed. The patient recovered with percutaneous abscess drainage and administration of intravenous antibiotics. Liver abscess recurred 1 mo later but was successfully treated with antibiotics. There has been little information on long-term outcomes of patients with AIP treated with surgery. To our knowledge, this is the second case of liver abscess after surgical treatment of AIP.

关键词： Autoimmune pancreatitis biliary reconstruction Liver abscess