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Clostridium difficile infection following colon subtotal resection in a patient with gallstones: A case report and review of literature

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 3048-3056页

作者： Feng Ke Zhen-Hua Dong Fan Bu Cheng-Nan Li Qi-Tong He Zhi-Cheng Liu Ji Lu Kai Yu Da-Guang Wang He-Nan Xu Chang-Tao Ye Department of General Surgery Affiliated Hospital of Changchun University of Chinese MedicineChangchun 130000Jilin ProvinceChina Department of Gastrointestinal Surgery The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Plastic and Aesthetic Surgery The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Encephalopathy Rehabilitation Chaoyi HospitalYanbian Korean Autonomous PrefectureYanji 133000Jilin ProvinceChina Department of Urology The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina

BACKGROUND Clostridium difficile(***)infection(CDI)is a rare clinical disease caused by changes in the intestinal microenvironment,which has a variety of causes and a poor prognosis,and for which there is no standardized clinical *** SUMMARY A patient experienced recurrent difficulty in bowel movements over the past ***,symptoms worsened within the last ten days,leading to a clinic visit due to *** patient was subsequently referred to our ***,the patient was diagnosed with obstructed colon accom-panied by *** antibiotics were administered both before and after surgery to prevent *** the fourth day post-surgery,symptoms of CDI *** cultures confirmed the presence of *** *** involved a combination of vancomycin and linezolid,resulting in the patient's successful recovery upon ***,the patient failed to adhere to the prescribed medication after discharge and was discovered deceased during a follow-up two months *** CDI is the leading cause of nosocomial post-operative care,with limited clinical cases and poor patient prognosis,and comprehensive clinical treatment guidelines are still *** infection can be triggered by a variety of factors,including intestinal hypoxia,inappropriate antibiotic use,and bile acid circulation *** patients with chronic bowel disease and related etiologies,prompt preoperative attention to possible CDI and preoperative bowel preparation is *** and prolonged medication should be maintained in the treatment of CDI to prevent recurrence of the disease.

关键词： Cholecystolithiasis Clostridium difficile bile acid circulation Intestinal microenvironment Case report

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