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Inhibitory activity of bifidobacterium adolescent combined with cisplatin on melanoma in mice and its mechanism

Frontiers of Medicine 2008年第2期2卷 186-190页

作者： Hongying HUANG Guangchao LIU Yijun QI Yaowu DU Jugao CHEN Yuanfang MA Key Laboratory of Cellular and Molecular Immunology Institute for ImmunologyHenan UniversityKaifeng 475004China

The aim of this study is to explore inhibitory activity of bifidobacterium adolescent combined with cis-platin on the growth of melanoma(B16)in mice and the underlying mechanism.C57 mice were inoculated with B16 cancer cells to construct mouse model of melanoma and treated with bifidobacterium adolescent combined with *** of inhibitory activity on the growth of melanoma(B16)were *** changes of the tumor were observed by HE staining.B16 cell cycles were examined on a flow *** prolif-eration was measured with MTT assay and the T-cell sub-set was measured by double marked *** bifidobacterium of 1010 cfu/L was injected,the ratio of inhibitory activity on the growth of melanoma(B16)reached 54%,which was similar to that of cisplatin *** ratio of inhibitory activity reached 74.45%when the mice were treated by bifidobacterium combined with *** staining shows that bifidobacterium inhibited B16 cell proliferation and enhanced the cisplatin`s killing activity on B16 *** results of flow cytometry demonstrated that B16 cell proliferation was arrested at G1 stage after treatment with *** B16 cell proliferation was arrested at S stage after treatment with *** CD4+percentage increased and the difference was significant compared with the normal group after treatment with bifidobacterium,indicating that T-cell immune activity was *** with bifidobacterium combined with cisplatin can enhance the inhibitory activity on the growth of melanoma(B16)of *** mechanism of the inhibitory activity on B16 cell proliferation is correlated with the enhanced immune activity in mice.

关键词： bifidobacterium adolescent cisplatin mela-noma,experimental

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