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Electromagnetic Fields and Calcium Signaling by the Voltage Dependent Anion Channel

Open Journal of Veterinary Medicine 2021年第1期11卷 57-86页

作者： Volker Ullrich Hans-Jürgen Apell Department of Biology University of Konstanz Konstanz Germany

Electromagnetic fields (EMFs) can interact with biological tissues exerting positive as well as negative effects on cell viability, but the underlying sensing and signaling mechanisms are largely unknown. So far in excitable cells EMF exposure was postulated to cause Ca2+ influx through voltage-dependent Ca channels (VDCC) leading to cell activation and an antioxidant response. Upon further activation oxidative stress causing DNA damage or cell death may follow. Here we report collected evidence from literature that voltage dependent anion channels (VDAC) located not only in the outer microsomal membrane but also in the cytoplasmic membrane convert to Ca2+ conducting channels of varying capacities upon subtle changes of the applied EMF even in non-excitable cells like erythrocytes. Thus, VDAC can be targeted by external EMF in both types of membranes to release Ca2+ into the cytosol. The role of frequency, pulse modulation or polarization remains to be investigated in suitable cellular models. VDACs are associated with several other proteins, among which the 18 kDa translocator (TSPO) is of specific interest since it was characterized as the central benzodiazepine receptor in neurons. Exhibiting structural similarities with magnetoreceptors we propose that TSPO could sense the magnetic component of the EMF and thus together with VDAC could trigger physiological as well as pathological cellular responses. Pulsed EMFs in the frequency range of the brain-wave communication network may explain psychic disturbances of electromagnetic hypersensitive persons. An important support is

关键词： Ca Signaling VDAC benzodiazepine receptor Mechanistic Concept Pulsed EMFs Electromagnetic Hypersensitivity TSPO Erythrocytes NADH-Oxidase Apoptosis Magnetosensor Membrane Potential Oxidative Stress Brain Signaling Autism

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PET imaging in stroke

PET imaging in stroke

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中国神经科学学会第十届全国学术会议

作者： Wolf-Dieter Heiss Max Planck Institute for Neurologigal Research

Cerebrovascular diseases are caused by interruption or significant impairment of blood supply to the brain,which leads to a cascade of metabolic and molecular alterations resulting in functional disturbance and morphological *** pathophysiological changes can be assessed by positron emission tomography（PET）,which permits to measure regionally various physiologic parameters and to image the distribution of molecular *** has broadened our understanding of flow and metabolic thresholds critical for maintenance of brain function and morphology:in this apphcation PET was essential in the transfer of the concept of the penumbra,*** with perfusion below the functional threshold,but above the threshold for preservation of morphology,to clinical stroke and thereby had a great impact on developing treatment *** for receptors can be applied as early markers of irreversible neuronal damage and thereby can predict the size of the final infarcts,which is also important for decisions of invasive therapy in large（ "malignant"） *** PET investigations the reserve capacity of blood supply to the brain can be tested in obstructive arteriosclerosis of supplying arteries,which again is essential for planning *** effect of a stroke on surrounding and contralateral primarily not-affected tissue can be investigated,and these results help to understand symptoms caused by disturbance in functional *** cerebrovascular disease causes vascular cognitive disorders including vascular dementia which *** increasing burden of the aging *** allows imaging the localized and / or diffuse metabolic disturbances responsible for cognitive impairment and dementia,and is effective in differentiatmg vascular dementia from degenerative dementia,as Alzheimer’s *** also may help to understand the importance of inflammatory changes and their interaction with amyloid depositions for the development of pos

关键词： Ischemic stroke penumbra,irreversible neuronal damage cerebral blood flow oxygen consumption glucose metabolism benzodiazepine receptor malignant infarction poststroke dementia vascular cognitive impairment

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