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中国化学会第十三届全国分析化学年会

作者： Xiong Yueting Liu Xiaohui Yang Pengyuan Institutes of Biomedical Sciences Fudan University The Fifth People's Hospital of Shanghai Fudan University

Objectives: By investigating the overall serum metabolic differences among pancreatic cancer（PC）, benign diseases（BD） and healthy individuals（normal control, NC）, in this study we aim to discover the particular metabolites as potential diagnostic markers for early diagnosis of PC. Design and methods: We combined both C18 and HILIC liquid chromatography separation and a high-resolution quadrupole time-of-flight mass spectrometer detection which was operated in negative and positive electrospray ionization mode together, in order to comprehensively analyze serum metabolites obtained from 20 patients with PC, 10 patients with BD and 10 NC. SWATH analysis was further utilized to validate metabolites which we have found in the discovery stage. Results: On the basis of our study, we identified 122 metabolites in total corresponding to various important pathways, such as butanoate metabolism, histidine metabolism and Synthesis and degradation of ketone bodies pathways in PC vs Control（BD and NC）. Besides, according to the PCA analysis based on the amount of the metabolites, the three groups can be well distinguished. Students’ T-test were used to find the altered metabolites, and 10 metabolites were more than 3 times different between BD and NC, while 14 metabolites can distinguish PC and NC. Conclusions: The newly found metabolites may be potential biomarkers for PC that can differentiate PC, BD patients and healthy individuals. More serum samples is now being collected and used for the validation and verification study.

关键词： LC-MS/MS Pancreatic cancer benign diseases Metabonomics Biomarker

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Review of oral and pharyngolaryngeal benign lesions detected during esophagogastroduodenoscopy

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World Journal of Gastrointestinal Endoscopy 2023年第7期15卷 496-509页

作者： Masaya Iwamuro Kenta Hamada Seiji Kawano Yoshiro Kawahara Motoyuki Otsuka Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558Japan Department of Practical Gastrointestinal Endoscopy Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558Japan

Recent advancements in endoscopy equipment have facilitated endoscopists’detection of neoplasms in the oral cavity and pharyngolaryngeal *** particular,image-enhanced endoscopy using narrow band imaging or blue laser imaging play an integral role in the endoscopic diagnosis of oral and pharyngolaryngeal *** these advancements,limited studies have focused on benign lesions that can be observed during esophagogastroduodenoscopy in the oral and pharyngolaryngeal ***,this mini-review aimed to provide essential information on such benign lesions,along with representative endoscopic images of dental caries,cleft palate,palatal torus,bifid uvula,compression by cervical osteophytes,tonsil hyperplasia,black hairy tongue,oral candidiasis,oral and pharyngolaryngeal ulcers,pharyngeal melanosis,oral tattoos associated with dental alloys,retention cysts,papilloma,radiation-induced changes,skin flaps,vocal cord paresis,and vocal fold *** it is imperative to seek consultation from otolaryngologists or dentists in instances where the diagnosis cannot be definitively ascertained by endoscopists,the merits of attaining foundational expertise pertaining to oral and pharyngolaryngeal lesions are *** article will be a valuable resource for endoscopists seeking to enhance their understanding of oral and pharyngolaryngeal lesions.

关键词： benign diseases Diagnosis Esophagogastroduodenoscopy Non-neoplastic lesions Oral lesions Pharyngolaryngeal lesions

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