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bell’s palsy after inactivated COVID-19 vaccination in a patient with history of recurrent bell’s palsy: A case report

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World Journal of Clinical Cases 2021年第27期9卷 8274-8279页

作者： Bin-Yan Yu Lu-sha Cen Ting Chen Tian-Hong Yang Department of Acupuncture and Moxibustion The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Traditional Chinese Medicine)Hangzhou 310006Zhejiang ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina Department of Ultrasonography The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina Department of Acupuncture and Moxibustion The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina

BACKGROUND With rapid and extensive administration of inactivated coronavirus disease 2019(COVID-19)vaccine to the general population in China,it is crucial for clinicians to recognize neurological complications or other side effects associated with COVID-19 *** sUMMARY Here we report the first case of bell’s palsy after the first dose of inactivated COVID-19 vaccine in *** patient was a 36-year-old woman with a past history of bell’s *** days after receiving the first dose of the sinovac Life sciences inactivated COVID-19 vaccine,the patient developed right-side bell’s palsy and binoculus ***,artificial tears and fluorometholone eye drops were *** patient’s symptoms began to improve by day 7 and resolved by day *** As mRNA COVID-19 vaccine trials reported cases of bell’s palsy as adverse events,we should pay attention to the occurrence of bell’s palsy after inactivated COVID-19 vaccination.A history of bell’s palsy,rapid increase of immunoglobulin M and immunoglobin G-specific antibodies to severe acute respiratory syndrome coronavirus 2 may be risk factors for bell‘s palsy after COVID-19 vaccination.

关键词： Recurrent bell’s palsy Keratoconjunctivitis Inactivated COVID-19 vaccination Case report

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sEMG based quantitative assessment of acupuncture on bell's palsy:an experimental study

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science China(Information sciences) 2015年第8期58卷 102-116页

作者： HAN JianDa XIONG AnBin ZHAO XinGang DING QiChuan CHEN YiGuo LIU GuangJun state Key Laboratory of Robotics Shenyang Institute of Automation Chinese Academy of Sciences University of Chinese Academy of sciences school of Acupuncture and Tuina Liaoning University of Traditional Chinese Medicine Department of Aerospace Engineering Ryerson University

Acupuncture is a traditional Chinese therapeutic method, recognized by western medicine as an important complementary therapy. However, the efficacy assessment of this traditional intervention has been mainly empirical rather than scientific. In this paper, we propose a surface electromyography(s EMG) based approach for quantitative assessment of acupuncture on bell’s palsy. The assessment is made by comparing the muscle activities of healthy with diseased ones. A feature-vector of four individual s EMG features is introduced for more comprehensive representation of muscle activity. A clustering technique is then proposed to calculate quantitative differences between the muscle activities of the healthy and diseased sides. A regressive model is also proposed to predict the recovery trend of a patient based on the quantitative assessments during his/her clinical acupuncture history. As reported in the paper, a total of 20 selected bell’s palsy patients have participated in the extensive experiments that were conducted to verify the performance of the proposed method.

关键词： acupuncture quantitative assessment s EMG bell’s palsy feature extraction PCA

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bell’s palsy workup:Does audiometry add value?

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Journal of Otology 2021年第2期16卷 61-64页

作者： Jing Yuan shirish Johari Aruni seneviratna Yaw Khian Chong Department of Otorhinolaryngology Tan Tock Seng HospitalSingapore Clinical Research&Innovation Office Tan Tock Seng HospitalSingapore

Objective:To investigate if routine audiometry in bell’s palsy patients has prognostic ***:Retrospective case review was conducted on all bell’s palsy patients(n紏191)seen at the tertiary otolaryngology specialist outpatient clinic from 2015 to *** of ipsilesional audiometric thresholds with patients’time-to-recovery and initial clinical severity(measured by House-Brackmann(HB)scoring)were used for the prognostic outcome *** results were analyzed using three contiguous frequency pure-tone average(1kHz,2kHz,4kHz).statistical analysis was done via stata(v13.1),significance tests were 2-sided at 5%significance ***:There was no significant difference between audiometric thresholds between the ipsilesional ear and the contralateral ear(p=0.87).Time-to-recovery was significantly longer for patients with severe initial presentation as compared to mild and moderate severity(ps no correlation found between the audiometry results and HB score at presentation(p=0.39).There was no correlation found between ipsilesional audiometric thresholds and time-to-recovery(p=0.58).Conclusion:Our study suggests that routine audiometry has limited prognostic value in bell’s palsy patients.

关键词： Audiometry bell’s palsy Audit Facial nerve Audiology Prognostic Outcomes

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Infrared thermography and meridian-effect evidence and explanation in bell's palsy patients treated by moxibustion at the Hegu (LI4) acupoint Overall regulation or a specific target?

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Neural Regeneration Research 2012年第9期7卷 680-685页

作者： Ling Guan Gaobo Li Yiling Yang Xiufang Deng Peisi Cai Department of Acupuncture and Moxibustion Chinese PLA General Hospital Beijing 100853 China Beijing Aierci Infrared Medical science and Technology Limited Company Beijing 100055 China

subjects with bell＇s palsy and healthy individuals were treated with moxibustion thermal stimulation on the Hegu （LI4） acupoint; an infrared thermal imaging system was used to observe facial-temperature changes. bell＇s palsy patients developed low or high temperatures at the affected side, with poor symmetry. Healthy people showed high temperatures on the forehead, medial angle of the eye, nasal ala and around the lips, but low temperatures on bilateral cheeks, thus forming a ＂T-type hot area＂ in the face, with good temperature symmetry. Moxibustion treatment for 11 minutes significantly improved high asymmetry in temperature in the faces of bell＇s palsy patients. This evidence indicates that moxibustion treatment on Hegu enables increases in facial temperatures in healthy people and bell＇s palsy patients, especially around the lips. Moxibustion stimulation at the Hegu not only improves the global circulation but also has specific effects on the lips in bell＇s palsy patients, but the underlying mechanism needs further investigation.

关键词： bell’s palsy infrared skin temperature face moxibustion neural regeneration

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bell's palsy at high altitude——an unsuspected finding

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Journal of Medical Colleges of PLA(China) 2016年第3期31卷 173-175页

作者： K.V.s.Hari Kumar K.P.shijith F.M.H.Ahmad Departments of Endocrinology Command Hospital Departments of Radiology Command Hospital Departments of Neurology Command Hospital

Background:bell's palsy is a common condition seen in clinical *** aetiology of this condition is not clearly defined and neuroimaging is essential to exclude intracranial causes of infra-nuclear facial *** presentation:We report a young soldier,who presented with bell's palsy and neuroimaging revealed an unsuspected finding of multiple intracranial *** evaluation revealed the additional diagnosis of vitamin D deficiency and secondary hyperparathyroidism due to lack of sun exposure at high altitude ***:The health care practitioners,looking after the soldiers at high altitude areas should be aware of the measures to prevent vitamin D *** calcifications are uncommon in hyperparathyroidism and bell's palsy.

关键词： bell’s palsy Hyperparathyroidism Vitamin D deficiency Intracranial calcification

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Psychological Factors Are Closely Associated with the bell's palsy: A Case-control study

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Journal of Huazhong University of science and Technology(Medical sciences) 2012年第2期32卷 272-279页

作者：黄波徐沙贝熊瑾黄光英张旻王伟 Department of Neurology and Psychology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Institute of Integrated Traditional and Western Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

To observe the differences in psychological status between bell’s palsy (BP) patients and healthy subjects, and to examine the relationship between psychological factors and the severity of BP, we conducted a case-control, multi-center clinical investigation. A total of 695 subjects were assigned to the case group (n=355) and the control group (n=340). House–Brackmann grading system and Facial Disability Index (FDI) were adopted to assess the BP patients; Kessler Psychological Distress scale (K10) and 16 Personality Factor (16PF) scale were employed to evaluate the psychological distress and personality profiles of all subjects. Two independent samples t test was used to compare the differences between cases and controls, and to compare the differences among different BP patients. Pearson correlation analysis was used to examine the relationship between psychological factors and severity of facial paralysis. The results showed that psychological distress (K10) in case group (27.09±5.80) was significantly higher than that in control group (13.43±3.02) (t=–37.219, P=0.000). The scores of personality factor Warmth (A), Openness to Change (Q1), self-Reliance (Q2) were lower in cases than in the controls (Pspectively), whereas the scores of sensitivity (I), Vigilance (L), Apprehension (O), and Tension (Q4) were significantly higher in cases than in the controls (Pspectively). In addition, the psychological distress was significantly higher in female patients, severe (HB score Ⅳ–Ⅵ) patients, and subacute (onset time 72–168 h) patients compared with that in male patients, mild (HB score Ⅰ–Ⅲ)patients, and acute (onset time≤72 h) patients (Pscores of personality factor in female patients, severe patients, and subacute patients were also significantly different from male patients, mild patients, and acute patients (Psult of Pearson correlation analysis showed that psychological factors (K10, p

关键词： bell’s palsy psychological distress personality factor

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Recovery from bell’s palsy after treatment using uncultured umbilical cord-derived mesenchymal stem cells:A case report

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World Journal of Clinical Cases 2023年第12期11卷 2817-2824页

作者： Hyunjun Ahn Won-Ju Jung sang Yeon Lee Kye-Ho Lee stem Cell Treatment and Research Institute bio Beauty and Health CompanySeoul 04420South Korea stem Cell Treatment 97.7 Beauty and Health ClinicSeoul 04420South Korea

BACKGROUND bell’s palsy is an idiopathic facial palsy with an unknown cause,and 75%of patients heal ***,the other 25%of patients continue experiencing mild or severe disabilities,resulting in a reduced quality of ***,various treatment methods have been developed to treat this ***,there is controversy regarding their effectiveness,and new alternative treatments are *** sUMMARY The patient suffered from left-sided facial paralysis due to bell’s palsy for 7 *** patient received an uncultured umbilical cord-derived mesenchymal stem cell transplant eight times for *** follow-up for 32 mo,the paralysis was cured,and there was no *** Uncultured umbilical cord-derived mesenchymal stem cell transplantation may be a potential treatment for patients with bell’s palsy who do not spontaneously recover.

关键词： bell’s palsy Facial palsy Umbilical cord-mesenchymal stem cells Allogenic Case report

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Acupuncture and moxibustion combined with western medication for ninety cases of bell’s palsy at different stages: A randomized controlled trial

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World Journal of Acupuncture-Moxibustion 2019年第4期29卷 249-253页

作者： Hui-fang Mao Wei Huang De-guang Ding Min Yao Ting Zhang Bei Xiao Department of Acupuncture and Moxibustion Hubei Hospital of Traditional Chinese MedicineWuhan 430000China

Objective:To observe the differences in the clinical effect on bell’s palsy at the acute stage and the recover stage,as well as the differences in the clinical effect between the simple acupuncture-moxibustion therapy and the combined therapy of acupuncture-moxibustion and western medication,explore the optimal intervention time point and therapeutic ***:All of the patients were collected from the outpatients and the inpatients in the specific Department of Acupuncture for Facial Paralysis in Hubei Chinese Medicine Hospital.A total of 128 patients with bell’s palsy were collected from February 2017 through to February 2018 and 90 patients of them were in compliance with the inclusion criteria.90 cases were randomized into three groups,named group A(acupuncture and moxibustion at the acute stage),group B(acupuncture and moxibustion combined with western medication at the acute stage)and group C(acupuncture and moxibustion combined with western medication at the recovery stage),30 cases in each *** the group A,acupuncture and moxibustion were adopted at the acute stage of bell’s *** the group B,at the acute stage,acupuncture and moxibustion were adopted in combination with the oral medication of hormone and *** the group C,at the recovery stage,acupuncture and moxibustion were adopted in combination with the oral medication of hormone and *** clinical healing time and the total effective rate were observed in the patients of the three groups and the occurrence of sequelae in facial paralysis was ***:①The clinical healing time in the Group B was slightly shorter than the Group A,but without statistical significance in comparison(P>0.05).The clinical healing time in either the Group A or the Group B was shorter than Group C,indicating the statistical significance in comparison(both Psults of 3-month follow-up observation showed that there were 3 cases of sequelae in the group A,2 cases in the Group B and 7

关键词： Acupuncture-moxibustion bell’s palsy Acute stage Recovery stage Hormonotherapy Vitamin

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bell’s palsy Post COVID-19 Vaccination: A Retrospective Cross-sectional study in a single Tertiary Center

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Journal of Biosciences and Medicines 2023年第12期11卷 47-53页

作者： Rohaizam Japar Jaafar Kalaiselvi Thuraisingam Asfa Najmi Mohamad Yusof Iskandar Hailani Department of Otorhinolaryngology—Head & Neck surgery (ORL-HNs) Hospital Kuala Lumpur Kuala Lumpur Malaysia Department of Otorhinolaryngology—Head & Neck surgery (ORL-HNs) Hospital Umum Sarawak Kuching Malaysia

Introduction: bell’s palsy is an uncommon adverse effect of the COVID-19 vaccine that has been reported in clinical trials. Even though a few studies have linked the vaccination to bell’s palsy, the actual mechanism is uncertain. Objectives: To describe the demographic data and COVID-19 vaccines-related data with bell’s palsy in a tertiary centre of Malaysia, Hospital Kuala Lumpur. Methods: A retrospective cross-sectional study was observed among vaccinated recipients who developed bell’s palsy within 60 days and sought treatment in the Otorhinolaryngology Department Hospital Kuala Lumpur, Malaysia between 1sup>stsup> May 2021 and 30sup>thsup> November 2021. The demographic data, clinical history, and vaccination history were collected from clinical records. The facial paralysis was graded according to the House-Brackmann grading system. Results: A total of 26 patients with a mean age was 38.5 years;higher incidence in younger age, below 60 years old (n = 24), specifically 18 - 30 years old (n = 11). We observed an equal number in relation to gender and onset (after the first or second dose) of facial palsy. Predominantly were Malay (n = 21) and only 6 patients had comorbidities. We found there was no difference in regard to the type of vaccine among bell’s palsy patients;Pfizer (n = 9), followed by sinovac (n = 9) and AstraZeneca (n = 8). Conclusion: bell’s palsy was found to be a possible adverse event of the COVID-19 vaccine. Younger groups were noted as susceptible to this rare adverse effect. However, the benefits of vaccination outweigh the risk of bell’s palsy, which has a good prognosis. More research with larger samples is needed to determine the true relationship between vaccination and bell’s palsy.

关键词： bell’s palsy COVID-19 Vaccination

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Efficacy of acupuncture and moxibustion in treating bell’s palsy: a multicenter randomized controlled trial in China

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Chinese Medical Journal 2004年第10期117卷 1502-1506页

作者：李瑛梁繁荣余曙光李常度胡玲香周东袁秀丽李怡夏晓红 Acupuncture and Tuina College Chengdu University of TCM Chengdu 610075 China First Affiliated Hospital of Chengdu University of TCM Chengdu 610075 China West China Hospital Sichuan University Chengdu 610042 China TCM Hospital of Mianyang City Mianyang 621000 China People’s Hospital of sichuan Province Chengdu 610075 China

Background bell’s palsy involves acute facial paralysis due to inflammation of the facial nerve. Acupuncture and moxibustion (acu-moxi) is beneficial in treating facial palsy. In order to verify the efficacy of acu-moxi on bell’s palsy, a randomized single-blind, multicenter clinical trial was *** A total of 480 patients from four clinical centers were involved in this trial, of whom 439 completed the trial and 41 did not. All patients were randomly assigned to either the control group or to one of two treatment groups. The control group was treated with prednisone, vitamin B_1, vitamin B_ 12, and dibazole; the treatment groups were treated either with acu-moxi alone or in combination with prednisone, Vitamin B_1, vitamin B_ 12, and dibazole. symptoms and signs, the House-Brackmann scale, and facial disability index (FDI) scores were assessed and determined both pre- and post-treatment to evaluate the effectiveness of the treatment *** The characteristics of the control and two treatment groups were comparable without statistically significant differences before treatment. There were significant differences between the control and treatment groups after treatment (χ2=15.265, P=0.018). According to evaluations based on the House-Brackmann scale and FDI scores, the effectiveness of treatment in the two treatment groups was better than in the control group and was most effective in patients receiving acu-moxi treatment alone (Z=-2.827, P=0.005). Conclusion The efficacy of acu-moxi treatment for bell’s palsy is verified scientifically.

关键词： acupuncture and moxibustion bell’s palsy multicenter trial randomized controlled trial House-Brackmann scale FDI score

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