检索结果-南通市图书馆

Di-(n-butyl)-phthalate-induced Oxidative Stress and Depression-like Behavior in Mice with or without Ovalbumin Immunization

引用

Biomedical and Environmental Sciences 2014年第4期27卷 268-280页

作者： ZUO Hao Xiao LI Jin Quan HAN Bing KE Chen Juan LIU Xu Dong ZHANG Yu Chao LI Li YANG Xu Section of Environmental Biomedicine Hubei Key Laboratory of Genetic Regulation and Integrative BiologyCollege of Life Sciences Central China Normal University Department of Molecular Pharmacology University Centre for Pharmacy University of Groningen

Objective To investigate the relationship between atopic allergy and depression and the role of DBP in the development of depression. Methods BALB/c mice were randomly divided into eight groups：saline;ovalbumin （OVA）-immunized;saline＋DBP （0.45 mg/kg·183;d）; saline＋DBP （45 mg/kg·d）; DBP （0.45 mg/kg·d） OVA-immunized; DBP （45 mg/kg·d） OVA-immunized; saline＋hydrocortisone （30 mg/kg·d）; and hydrocortisone （30 mg/kg·d）-exposed OVA-immunized. Behavior （e.g. open-field, tail suspension, and forced swimming tests）, viscera coefficients （brain and spleen）, oxidative damage [e.g. reactive oxygen species （ROS）, malondialdehyde （MDA）, and glutathione （GSH）], as well as levels of IgE and IL-4, were then analyzed. Results In the saline and OVA groups, the degree of depression symptoms in mice increased with increasing DBP concentration. Additionally, the OVA-immunity groups were associated with more serious depressive behavior compared with the same exposure concentration in the saline group. Oxidative damage was associated with a dose-dependent increase in DBP in the different groups. IL-4 and IgE levels were associated with low-dose DBP stimulation, which changed to high-dose inhibition with increasing DBP exposure, possibly due to spleen injury seen at high DBP *** Development of an atopic allergy has the potential to increase the risk of depression in mice, and it seems that DBP helps OVA to exert its effect in our present model. Moreover, the results of our study implicate a certain connection between brain oxidative stress and depression, which deserves a further exploration.

关键词： Di (n-butyl) phthalate Atopic allergy Depression Mice Oxidative stress behavioral tests

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Labial tip sensilla of Blissus leucopterus leucopterus （Hemiptera： Blissidae）： Ultrastructure and behavior

引用

Insect Science 2008年第3期15卷 271-275页

作者： Gerald T. Baker Xiong Chen Peter W.K. Ma Department of Entomology and Plant Pathology Box 9775 Mississippi State University Mississippi State MS 39762 USA

The cuticular sensory receptors that are found on the apex of the labium of hemipterans play an important role in their feeding behavior. In this study we describe the ultrastructure, number, and distribution of sensilla on the labium apex of the chinch bug, Blissus leucopterus leucopterus. Each apical field of sensilla on the labium contains 11 uniporous peg sensilla and one sensillum chaeticum. The uniporous peg sensilla are innervated by 4-5 bipolar neurons that send dendrites in the lumen of each peg. Three neurons are associated with each sensillum chaeticum, two neurons have dendrites in the lumen of the sensillum, and the third dendrite ends in a tubular body at the base of the sensillum. behavioral tests that involve chemical blockage of the sensory receptors show the importance of the labial sensilla in feeding behavior. Both morphological and behavioral evidence indicate that the labial sensilla have a chemosensitive function.

关键词： behavioral tests chinch bug electron microscopy labial sensilla Nmethylmaleimide

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Death-associated protein kinase 1 is associated with cognitive dysfunction in major depressive disorder

引用

Neural Regeneration Research 2023年第8期18卷 1795-1801页

作者： Xiao-Hui Li Hong-Can Zhu Xue-Min Cui Wang Wang Lin Yang Li-Bo Wang Neng-Wei Hu Dong-Xiao Duan Department of Physiology and Neurobiology School of Basic Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina

We previously showed that death-associated protein kinase 1(DAPK1)expression is increased in hippocampal tissue in a mouse model of major depressive disorde and is related to cognitive dysfunction in Alzheimer's *** addition,depression is a risk factor for developing Alzheimer's disease,as well as an early clinical manifestation of Alzheimer's ***,cognitive dysfunction is a distinctive feature of major depressive ***,DAPK1 may be related to cognitive dysfunction in major depressive *** this study,we established a mouse model of major depressive disorder by housing mice individually and exposing them to chronic,mild,unpredictable *** found that DAPK1 and tau protein levels were increased in the hippocampal CA3 area,and tau was hyperphosphorylated at Thr231,Ser262,and Ser396 in these ***,DAPK1 shifted from axonal expression to overexpression on the cell *** and treatment with the antidepressant drug citalopram decreased DAPK1 expression and tau protein phosphorylation in hippocampal tissue and improved both depressive symptoms and cognitive *** results indicate that DAPK1 may be a potential reason and therapeutic target of cognitive dysfunction in major depressive disorder.

关键词： Alzheimer's disease antidepressant drug behavioral tests cognitive dysfunction death-associated protein kinase 1 exercise hippocampus major depressive disorder phosphorylation tau protein

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A red pomegranate fruit extract-based formula ameliorates anxiety/depression-like behaviors via enhancing serotonin (5-HT) synthesis in C57BL/6 male mice

引用

Food Science and Human Wellness 2021年第3期10卷 289-296页

作者： Xiping Zhu Dongxiao Sun-Waterhouse Chun Cui College of Food Science and Engineering South China University of TechnologyGuangzhou 510640GuangdongChina College of Biological and Food Engineering Anhui Polytechnic UniversityWuhu 241000AnhuiChina Guangdong Weiwei Biotechnology Co. LTD.Guangzhou 510640China

This study investigated the anti-anxiety/anti-depression potential of a formula containing red pomegranate fruit extract(RPFE;40%,m/m),Lactobacillus rhamnosus(JB-1)(34%,m/m),magnesium gluconate(25%,m/m)and vanillin(1%,m/m).The RPFE formula(dose:2.0,1.5 or 1.0 mg/g·day)reversed behavioral dysfunctions and body weight gain induced by chronic restraint stress combined with corticosterone injection in C57BL/6 male *** RPFE formula exhibited the abilities to normalize the levels of serum infl ammatory cytokines(NF-κB,TNF-α,IL-6,IL-1βand IFN-γ)and malondialdehyde(MDA),and activities of superoxide dismutase(SOD),catalase(CAT)and nitric oxide synthase(NOS),as well as relieve the injury of hippocampal *** serotonin(5-HT)levels in hippocampus were increasingly enhanced,which might be mediated by reducing the activity of indoleamine-2,3-dioxygenase(IDO)and increasing the activity of tryptophan hydroxylase(TPH).Thus,the neuroprotective and ameliorating effects on anxiety/depression-like behaviors resulting from the RPFE formula ingestion were possibly related to serotonergic activation,which might be mediated via anti-infl ammatory and anti-oxidant actions.

关键词： behavioral tests Red pomegranate fruit extract 5-HT Anti-infl ammatory Anxiety/depression

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent advances in anxiety disorders:Focus on animal models and pathological mechanisms

引用

Animal Models and Experimental Medicine 2023年第6期6卷 559-572页

作者： Hongqing Zhao Mi Zhou Yang Liu Jiaqi Jiang Yuhong Wang Science&technology innovation center Hunan University of Chinese MedicineChangshaChina

Anxiety disorders have become one of the most severe psychiatric disorders,and the incidence is increasing every *** impose an extraordinary personal and socioeconomic *** disorders are influenced by multiple complex and interacting genetic,psychological,social,and environmental factors,which contribute to disruption or imbalance in homeostasis and eventually cause pathologic *** selection of a suitable animal model is important for the exploration of disease etiology and pathophysiology,and the development of new ***,a more comprehensive understanding of the advantages and limitations of existing animal models of anxiety disorders is helpful to further study the underlying pathological mechanisms of the *** review summarizes animal models and the pathogenesis of anxiety disorders,and discusses the current research status to provide insights for further study of anxiety disorders.

关键词： animal models anxiety disorders behavioral tests mental diseases pathogenesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel method to detect cognitive behaviors in 5XFAD mouse model

A novel method to detect cognitive behaviors in 5XFAD mouse ...

引用

中国神经科学学会第十二届全国学术会议

作者： Yang Li Lijuan Li Yan Zheng Xiaomin Wang Department of Physiology Department of Neurobiology Key Laboratory for Neurodegenerative Disorders of the Ministry of Education Capital Medical University

Objective Alzheimer’s disease（AD） is the most common neurodegenerative disease in the elderly. The early events including behavioral impairment and related pathogenesis in AD process are not completely understood, although the decline in learning and memory in AD mouse model has been widely reported. This may probably due to few behavioral tests can be used to discover early cognitive impairment in AD mouse model. The present study was designed to uncover the cognitive changes in very early stage of AD when hippocampus-dependent memory of the AD mouse was normal. Methods The 3-month-old 5 XFAD mice and littermates wild-type（WT） control mice were used in our study. We examined cognitive flexibility by a rule-shifting task, and the Morris water maze（MWM） was performed to reveal their ability of spatial learning and memory. Results Our results indicated rule-shifting deficit in 5 XFAD mice compared to WT mice although there was no difference between 3-month-old 5 XFAD mice and WT mice in the MWM. Conclusion The inflexibility behavior can be used to indicate the early stage of AD process in mouse model.

关键词： Alzheimer’s disease early detection behavioral tests 5XFAD mice

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：