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Death-associated protein kinase 1 is associated with cognitive dysfunction in major depressive disorder

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Neural Regeneration Research 2023年第8期18卷 1795-1801页

作者： Xiao-Hui Li Hong-Can Zhu Xue-Min Cui Wang Wang Lin Yang Li-Bo Wang Neng-Wei Hu Dong-Xiao Duan Department of Physiology and Neurobiology School of Basic Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina

We previously showed that death-associated protein kinase 1(DAPK1)expression is increased in hippocampal tissue in a mouse model of major depressive disorde and is related to cognitive dysfunction in Alzheimer's *** addition,depression is a risk factor for developing Alzheimer's disease,as well as an early clinical manifestation of Alzheimer's ***,cognitive dysfunction is a distinctive feature of major depressive ***,DAPK1 may be related to cognitive dysfunction in major depressive *** this study,we established a mouse model of major depressive disorder by housing mice individually and exposing them to chronic,mild,unpredictable *** found that DAPK1 and tau protein levels were increased in the hippocampal CA3 area,and tau was hyperphosphorylated at Thr231,Ser262,and Ser396 in these ***,DAPK1 shifted from axonal expression to overexpression on the cell *** and treatment with the antidepressant drug citalopram decreased DAPK1 expression and tau protein phosphorylation in hippocampal tissue and improved both depressive symptoms and cognitive *** results indicate that DAPK1 may be a potential reason and therapeutic target of cognitive dysfunction in major depressive disorder.

关键词： Alzheimer's disease antidepressant drug behavioral tests cognitive dysfunction death-associated protein kinase 1 exercise hippocampus major depressive disorder phosphorylation tau protein

A red pomegranate fruit extract-based formula ameliorates anxiety/depression-like behaviors via enhancing serotonin (5-HT) synthesis in C57BL/6 male mice

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Food Science and Human Wellness 2021年第3期10卷 289-296页

作者： Xiping Zhu Dongxiao Sun-Waterhouse Chun Cui College of Food Science and Engineering South China University of TechnologyGuangzhou 510640GuangdongChina College of Biological and Food Engineering Anhui Polytechnic UniversityWuhu 241000AnhuiChina Guangdong Weiwei Biotechnology Co. LTD.Guangzhou 510640China

This study investigated the anti-anxiety/anti-depression potential of a formula containing red pomegranate fruit extract(RPFE;40%,m/m),Lactobacillus rhamnosus(JB-1)(34%,m/m),magnesium gluconate(25%,m/m)and vanillin(1%,m/m).The RPFE formula(dose:2.0,1.5 or 1.0 mg/g·day)reversed behavioral dysfunctions and body weight gain induced by chronic restraint stress combined with corticosterone injection in C57BL/6 male *** RPFE formula exhibited the abilities to normalize the levels of serum infl ammatory cytokines(NF-κB,TNF-α,IL-6,IL-1βand IFN-γ)and malondialdehyde(MDA),and activities of superoxide dismutase(SOD),catalase(CAT)and nitric oxide synthase(NOS),as well as relieve the injury of hippocampal *** serotonin(5-HT)levels in hippocampus were increasingly enhanced,which might be mediated by reducing the activity of indoleamine-2,3-dioxygenase(IDO)and increasing the activity of tryptophan hydroxylase(TPH).Thus,the neuroprotective and ameliorating effects on anxiety/depression-like behaviors resulting from the RPFE formula ingestion were possibly related to serotonergic activation,which might be mediated via anti-infl ammatory and anti-oxidant actions.

关键词： behavioral tests Red pomegranate fruit extract 5-HT Anti-infl ammatory Anxiety/depression

Recent advances in anxiety disorders:Focus on animal models and pathological mechanisms

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Animal Models and Experimental Medicine 2023年第6期6卷 559-572页

作者： Hongqing Zhao Mi Zhou Yang Liu Jiaqi Jiang Yuhong Wang Science&technology innovation center Hunan University of Chinese MedicineChangshaChina

Anxiety disorders have become one of the most severe psychiatric disorders,and the incidence is increasing every *** impose an extraordinary personal and socioeconomic *** disorders are influenced by multiple complex and interacting genetic,psychological,social,and environmental factors,which contribute to disruption or imbalance in homeostasis and eventually cause pathologic *** selection of a suitable animal model is important for the exploration of disease etiology and pathophysiology,and the development of new ***,a more comprehensive understanding of the advantages and limitations of existing animal models of anxiety disorders is helpful to further study the underlying pathological mechanisms of the *** review summarizes animal models and the pathogenesis of anxiety disorders,and discusses the current research status to provide insights for further study of anxiety disorders.

关键词： animal models anxiety disorders behavioral tests mental diseases pathogenesis

Di-(n-butyl)-phthalate-induced Oxidative Stress and Depression-like Behavior in Mice with or without Ovalbumin Immunization

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Biomedical and Environmental Sciences 2014年第4期27卷 268-280页

作者： ZUO Hao Xiao LI Jin Quan HAN Bing KE Chen Juan LIU Xu Dong ZHANG Yu Chao LI Li YANG Xu Section of Environmental Biomedicine Hubei Key Laboratory of Genetic Regulation and Integrative BiologyCollege of Life Sciences Central China Normal University Department of Molecular Pharmacology University Centre for Pharmacy University of Groningen

Objective To investigate the relationship between atopic allergy and depression and the role of DBP in the development of depression. Methods BALB/c mice were randomly divided into eight groups：saline;ovalbumin （OVA）-immunized;saline＋DBP （0.45 mg/kg·183;d）; saline＋DBP （45 mg/kg·d）; DBP （0.45 mg/kg·d） OVA-immunized; DBP （45 mg/kg·d） OVA-immunized; saline＋hydrocortisone （30 mg/kg·d）; and hydrocortisone （30 mg/kg·d）-exposed OVA-immunized. Behavior （e.g. open-field, tail suspension, and forced swimming tests）, viscera coefficients （brain and spleen）, oxidative damage [e.g. reactive oxygen species （ROS）, malondialdehyde （MDA）, and glutathione （GSH）], as well as levels of IgE and IL-4, were then analyzed. Results In the saline and OVA groups, the degree of depression symptoms in mice increased with increasing DBP concentration. Additionally, the OVA-immunity groups were associated with more serious depressive behavior compared with the same exposure concentration in the saline group. Oxidative damage was associated with a dose-dependent increase in DBP in the different groups. IL-4 and IgE levels were associated with low-dose DBP stimulation, which changed to high-dose inhibition with increasing DBP exposure, possibly due to spleen injury seen at high DBP *** Development of an atopic allergy has the potential to increase the risk of depression in mice, and it seems that DBP helps OVA to exert its effect in our present model. Moreover, the results of our study implicate a certain connection between brain oxidative stress and depression, which deserves a further exploration.

关键词： Di (n-butyl) phthalate Atopic allergy Depression Mice Oxidative stress behavioral tests

A novel method to detect cognitive behaviors in 5XFAD mouse model

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A novel method to detect cognitive behaviors in 5XFAD mouse ...