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Tetrahydroxy stilbene glucoside improved the behavioral disorders of APP695V717l transgenic mice by inhibiting the expression of Beclin-1 and LC3-Ⅱ

引用

Journal of Traditional Chinese Medicine 2015年第3期35卷 295-300页

作者： Luo Hongbo Li Yun Guo Jiankui Liu Zunjing Zhang Zhiqiang Wang Yong Liu Zhao Shi Xiangqun Department of Neurology Lanzhou General HospitalLanzhou Military Area Command Department of Neurology China-Japan Friendship Hospital

OBJECTIVE:To observe the effect of tetrahydroxy stilbene glucoside(TSG) on the behavior of APP695V717 I transgenic mouse models and the expression of autophagy-associated proteins Beclin-1and LC3-Ⅱ.METHODS:Forty 3-month-old APP695V717 I transgenic mice were randomized equally into either a TSG group(n = 20) or a model group(n = 20).A normal control group consisted of C57BL/6J mice of the same age and background(n = 20).The TSG group received TSG intragastric administration for1 *** was measured using the Morris water maze and the Y-maze *** in protein expression and mRNA of autophagy-associated Beclin-1 and LC3-Ⅱ in mice hippocampus were detected by western blot and Reverse Transcription-Polymerase Chain Reaction(RT-PCR) ***:The number of electric-stimulus escapes significantly increased and the Morris water maze test showed prolonged escape latency,greater swimming distance,less time taken to cross the exact former platform location in the model group,and increased mRNA and protein expressions of Beclin-1 and LC3-Ⅱ compared with the control group(P protein expressions of Beclin-1 and LC3-Ⅱ compared with the model group(P1 and LC3-Ⅱ in the autophagy *** can attenuate injury to endoplasmic reticulum functions caused by Ab neurotoxicity,improving learning,memorizing,and spatial orientation behavior in mice.

关键词： Mice,tansgenic becn1 protein LC3 protein Tetrahydroxy stilbene glucoside Behavior

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