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2016年广东省药师周大会

作者： Xin Chen Yingbo Kang Liqing Wang Lin Lin Zhe Zhu Rui Chen Department of Respiratory Diseases Zhujiang Hospital of Southern Medical University Department of Pharmacy Zhujiang Hospital of Southern Medical University Department of Respiratory Diseases SUN Yat-sen Memorial HospitalSUN Yat-Sen University

The small-particle inhaled corticosteroid might be a new available way to treat uncontrolled *** evaluate the efficacy and safety of extrafine hydrofluoroalkane-beclomethasone dipropionate(HFA-BDP) versus budesonide(BUD) in patients with asthma,a meta-analysis was performed.A systematic search was made of Pub Med,EMBASE,Cochrane Central Register of Controlled Trials(CENTRAL),*** and Ovid,and a hand search of leading respiratory *** controlled trials(RCTs) on treatment of asthma for 4 or more weeks with extrafine HFA-BDP,compared with BUD,were *** studies involving 949 asthmatic patients met the inclusion *** was no significant difference in FEV1(SMD=-0.03 L,95% CI-0.15 to 0.10 L,I2=0%,P=0.70),morning PEF(WMD=0.88 L/min,95% CI-5.96 to 7.72 L/min,I2=0%,P=0.80),evening PEF(WMD=6.32 L/min,95% CI-1.17 to 13.81 L/min,I2=33%,P=0.10) and use of rescue medication(WMD=-0.13,95% CI-0.31 to 0.06,I2=41%,P=0.18) between extrafine HFA-BDP at half of the daily dose and BUD *** studies reported no significant differences in asthma exacerbations and 7-point Asthma Control Questionnaire score(ACQ-7).There were no significant difference in total number of adverse events(OR=1.04,95% CI 0.78 to 1.38,I2=0%,P=0.81) between the two *** meta-analysis demonstrated that extrafine HFA-BDP at half of daily dose is equivalent to BUD in improving lung function and use of rescue medication,without increasing adverse events in patients with ***-term trials are required to assess the efficacy and safety of extrafine HFA-BDP.

关键词： Asthma extrafine beclomethasone budesonide meta-analysis

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倍氯米松(beclomethasone)商品名及别名

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临床药物治疗杂志 2006年第3期4卷 62-62页

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Impact of inhaled and intranasal corticosteroids on glucose metabolism and diabetes mellitus:A mini review

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World Journal of Diabetes 2023年第8期14卷 1202-1211页

作者： Kay Choong See Department of Medicine National University HospitalSingapore 119228Singapore

Inhaled corticosteroids(ICS)and intranasal corticosteroids(INS)are the mainstays of treatment for chronic respiratory diseases like asthma,chronic obstructive pulmonary disease,and allergic *** addition,these localized forms of steroid therapy are generally considered to have fewer systemic side effects compared to long-term oral ***,concern and controversy remain over the impact of ICS and INS on the incidence and control of diabetes mellitus(DM).Given the widespread use of ICS and INS,even small individual effects on DM could lead to large consequences for the global *** large observational studies suggest that high dose ICS is associated with increased incident DM and worsened DM control,though the contribution of other risk factors is less *** addition,only two studies were done to investigate the association of INS and DM,with both studies demonstrating a short-term association of INS use with *** more research evaluating the risk of ICS/INS for DM-related adverse events is needed,high doses of ICS/INS should be avoided when *** following strategies for ICS/INS dose minimization can be considered:Use of non-pharmacological measures(trigger avoidance,smoking cessation,vaccination to avoid infection),control of comorbid conditions,use of non-ICS-containing medications,intermittent rather than regular ICS dosing,and appropriate de-escalation of high ICS doses.

关键词： beclomethasone Budesonide Fluticasone Glucocorticoids Glucose Hyperglycemia

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Prevention of pelvic radiation disease

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2015年第1期6卷 1-9页

作者： Lorenzo Fuccio Leonardo Frazzoni Alessandra Guido Department of Medical and Surgical Sciences S.Orsola-Malpighi Hospital University of Bologna Division of Radiation Oncology S.OrsolaMalpighi Hospital University of Bologna

Pelvic cancers are among the most frequently diagnosed cancers worldwide. Treatment of patients requires a multidisciplinary approach that frequently includes radiotherapy. Gastrointestinal(GI) radiation-induced toxicity is a major complication and the transient or long-term problems, ranging from mild to very severe, arising in non-cancerous tissues resulting from radiation treatment to a tumor of pelvic origin, are actually called as pelvic radiation disease. The incidence of pelvic radiation disease changes according to the radiation technique, the length of follow up, the assessmentmethod, the type and stage of cancer and several other variables. Notably, even with the most recent radiation techniques, i.e., intensity-modulated radiotherapy, the incidence of radiation-induced GI side effects is overall reduced but still not negligible. In addition, radiation-induced GI side effects can develop even after several decades; therefore, the improvement of patient life expectancy will unavoidably increase the risk of developing radiation-induced complications. Once developed, the management of pelvic radiation disease may be challenging. Therefore, the prevention of radiation-induced toxicity represents a reasonable way to avoid a dramatic drop of the quality of life of these patients. In the current manuscript we provide an updated and practical review on the best available evidences in the field of the prevention of pelvic radiation disease.

关键词： Pelvic radiation disease Radiotherapy Gastrointestinal toxicity Amifostine Aminosalicylates Sucralfate beclomethasone dipropionate Probiotics supplementation Misoprostol Mesalazine

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